PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35626081-10 2022 Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3. Citric Acid 142-149 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 194-198 7929613-5 1994 Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake. Citric Acid 65-72 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 85-89 34924279-10 2021 Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2. Citric Acid 48-55 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 149-153 34924279-10 2021 Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2. Citric Acid 102-109 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 149-153 34924279-11 2021 As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment. Citric Acid 105-112 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 131-135 35626081-10 2022 Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3. Citric Acid 142-149 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 199-205 24604252-3 2014 The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively. Citric Acid 370-377 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 12-65 24604252-3 2014 The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively. Citric Acid 370-377 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Homo sapiens 67-73