PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7929613-5	1994	Coordinated inhibition of glycolytic flux mediated by effects of citrate on PFK1 and PFK2 in muscles and liver results in an associated inhibition of glucose uptake.	Citric Acid	65-72	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	85-89	
35626081-10	2022	Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3.	Citric Acid	142-149	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	194-198	
35626081-10	2022	Awaiting the development of non-toxic inhibitors of these enzymes, we propose to test the administration of citrate at a high dosage, because citrate is a physiologic inhibitor of both PFK1 and PFK2/PFKFB3.	Citric Acid	142-149	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	199-205	
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	48-55	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	149-153	
34924279-10	2021	Here, we suggest that this could be achieved by citrate administration at high concentration, because citrate is a physiologic inhibitor of PFK1 and PFK2.	Citric Acid	102-109	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	149-153	
34924279-11	2021	As shown in various in vitro studies, including HCC cell lines, administration of high concentrations of citrate inhibits PFK1 and PFK2 (and consequently glycolysis), decreases ATP production, counteracts HIF-1alpha and PI3K/AKT signaling, induces apoptosis, and sensitizes cells to cisplatin treatment.	Citric Acid	105-112	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	131-135	
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	12-65	
24604252-3	2014	The enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) and glutaminase-1 (GLS1) maintain a high abundance in glycolytic intermediates (for synthesis of non-essential amino acids, the use of ribose for the synthesis of nucleotides and hexosamine biosynthesis), as well as tricarboxylic acid cycle intermediates (replenishing the loss of mitochondrial citrate), respectively.	Citric Acid	370-377	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	67-73