PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8080091-5 1994 The method was used to demonstrate association between two enzymes of the mitochondrial citric acid cycle, malate dehydrogenase and citrate synthase, and between the lysosomal hydrolases, beta-galactosidase and cathepsin A. Citric Acid 88-99 citrate synthase Homo sapiens 132-148 8447387-4 1993 Muscle citrate concentration at the end of exercise correlated significantly with CS activity (r = 0.70; P < 0.005) and was slightly but not significantly higher after training (0.80 +/- 0.19 vs. 0.54 +/- 0.19 mmol/kg dry wt; P = 0.16). Citric Acid 7-14 citrate synthase Homo sapiens 82-84 8345822-1 1993 Citrate synthase catalyzes the condensation of acetyl-coenzyme A (CoA) and oxaloacetic acid to form citric acid. Citric Acid 100-111 citrate synthase Homo sapiens 0-16 3949736-4 1986 Oxaloacetate and citrate, substrates for the forward and reverse reaction catalyzed by citrate synthase, affect dimerization at concentrations of the protein which exists as monomer in their absence. Citric Acid 17-24 citrate synthase Homo sapiens 87-103 1991136-5 1991 Spermine, which contributes to an activation of Ca2(+)-sensitive dehydrogenases of the citric acid cycle by enhancing Ca2+ uptake into mitochondria, can activate citrate synthase directly, and is responsible for the stimulation of oxidative metabolism in mitochondria. Citric Acid 87-98 citrate synthase Homo sapiens 162-178 35434198-5 2022 The functioning of the roTCA cycle requires unusually high activity of citrate synthase, the enzyme responsible for citrate cleavage, as well as elevated CO2 partial pressures. Citric Acid 116-123 citrate synthase Homo sapiens 71-87 35343271-10 2022 These beneficial effects are accompanied by a stimulus of the citric acid cycle-which feed the mitochondrial complexes with the electrons removed from different substrates-as the result of accentuated stimulus of citrate synthase activity by BMMC. Citric Acid 62-73 citrate synthase Homo sapiens 213-229 3332992-5 1987 From affinity chromatographic experiments, we have shown that the enzymes of the citric acid cycle and the aspartate-malate shuttle are organized as one huge multi-enzyme complex, and a stoichiometric arrangement of fumarase/malate dehydrogenase/citrate synthase/aspartate aminotransferase has been postulated. Citric Acid 81-92 citrate synthase Homo sapiens 246-262 34923382-5 2022 A pyrene removal rate of 90.53% was achieved in aqueous solutions and an above 80% removal rate was obtained in weakly acidic or neutral soil environments by CS-U@PS activated by Fe2+ with citric acid as the chelating agent. Citric Acid 189-200 citrate synthase Homo sapiens 158-160 34548590-3 2021 Microscale Thermophoresis analysis of the porcine heart MDH-CS complex revealed that substrates of the MDH and CS reactions, NAD+ and acetyl-CoA, enhance complex association while products of the reactions, NADH and citrate, weaken the affinity of the complex. Citric Acid 216-223 citrate synthase Homo sapiens 60-62 34186087-3 2021 Citrate synthase (CS) is one of only two irreversible steps in the citric acid cycle (CAC) and forms an important regulatory checkpoint that gates the entry of acetyl-CoA formed in glycolysis or fatty acid catabolism into this critical central metabolic hub. Citric Acid 67-78 citrate synthase Homo sapiens 0-16 3949736-7 1986 In light of recent evidence derived from x-ray crystallographic studies showing amino acid residues from one subunit contributing to the citrate and CoA binding sites of the other, the dissociation into monomers would be expected to have profound effects on citrate synthase activity and regulation, as well as overall tricarboxylic acid cycle activity. Citric Acid 137-144 citrate synthase Homo sapiens 258-274 1003-2 1975 The activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenases were measured in nervous tissue from different animals in an attempt to provide more information about the citric acid cycle in this tissue. Citric Acid 201-212 citrate synthase Homo sapiens 18-34 925022-3 1977 Acetylation can be prevented by metabolizing the available acetyl-CoA to citrate with the addition of citrate synthase and oxalacetate to the translation system. Citric Acid 73-80 citrate synthase Homo sapiens 102-118 5165527-0 1971 Stereochemistry of the interconversions of citrate and acetate catalyzed by citrate synthase, adenosine triphosphate citrate lyase, and citrate lyase. Citric Acid 43-50 citrate synthase Homo sapiens 76-92 175415-8 1975 Citric acid cycle flux was coordinated by activational interactions at citrate synthase, isocitrate dehydrogenase, and alpha-ketoglutarate dehydrogenase, but a transient imbalance between the individual cycle steps leads to a sharp peak of lactate production shortly after the work transition. Citric Acid 0-11 citrate synthase Homo sapiens 71-87 4962163-18 1967 Citrate formation was enhanced, owing to de-inhibition of citrate synthase. Citric Acid 0-7 citrate synthase Homo sapiens 58-74 27769451-2 2016 Our biosensing approach provides an especial and significant detection mechanism: CS can catalyze the essential condensation reaction between acetyl-coenzyme A (Ac-CoA) and oxaloacetate (OAA) to form citrate and CoA; then, in the presence of Ag(I), CoA-Ag(I) CP can be in situ formed because of the strong complexation ability of thiol groups of CoA toward Ag(I). Citric Acid 200-207 citrate synthase Homo sapiens 82-84 32801864-1 2020 Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate. Citric Acid 64-71 citrate synthase Homo sapiens 9-25 32801864-1 2020 Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate. Citric Acid 64-71 citrate synthase Homo sapiens 27-29 32801864-1 2020 Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate. Citric Acid 138-145 citrate synthase Homo sapiens 9-25 32801864-1 2020 Purpose: Citrate synthase (CS) is a rate-limiting enzyme in the citrate cycle and is capable of catalyzing oxaloacetate and acetyl-CoA to citrate. Citric Acid 138-145 citrate synthase Homo sapiens 27-29 28467904-4 2017 During this period, the inhibition of STAT3 blocks the expression of citrate synthase (CS) and reduces the levels of intracellular citrate. Citric Acid 69-76 citrate synthase Homo sapiens 87-89 28467904-6 2017 These effects were due to STAT3-dependent transcriptional regulation of CS, as exogenous addition of citrate could restore fatty acid synthesis, cell growth, and proliferation. Citric Acid 101-108 citrate synthase Homo sapiens 72-74 33435350-0 2021 Rethinking the Citric Acid Cycle: Connecting Pyruvate Carboxylase and Citrate Synthase to the Flow of Energy and Material. Citric Acid 15-26 citrate synthase Homo sapiens 70-86 28391595-4 2017 In mitochondria, it is possible that some or all of the enzymes of the citric acid cycle, including citrate synthase, are organized in metabolons to facilitate the channelling of substrates between participating enzymes. Citric Acid 71-82 citrate synthase Homo sapiens 100-116 26010859-8 2015 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems. Citric Acid 117-128 citrate synthase Homo sapiens 53-69 26010859-8 2015 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and citrate synthase (CS), which are involved in glycolysis and the citric acid cycle, respectively, were expressed at similar levels at 32 C and 37 C in pellet cultures, but the levels were significantly lower at 41 C. Expression of the chondrogenic markers, collagen type IIA1 (COL2A1) and aggrecan (ACAN), was higher at 37 C than at 32 C and 41 C in both culture systems. Citric Acid 117-128 citrate synthase Homo sapiens 71-73 12549038-3 2000 Citrate synthase plays a key role in regulating TCA cycle and is responsible for catalysing the synthesis of citrate from oxaloacetate and acetyl CoA. Citric Acid 109-116 citrate synthase Homo sapiens 0-16 25545012-1 2014 Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate. Citric Acid 167-174 citrate synthase Homo sapiens 0-16 25545012-1 2014 Citrate synthase (CS), one of the key enzymes in the tricarboxylic acid (TCA) cycle, catalyzes the reaction between oxaloacetic acid and acetyl coenzyme A to generate citrate. Citric Acid 167-174 citrate synthase Homo sapiens 18-20 24948467-1 2014 Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life. Citric Acid 61-72 citrate synthase Homo sapiens 0-16 24948467-1 2014 Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life. Citric Acid 61-72 citrate synthase Homo sapiens 18-20 24720842-1 2014 The enzyme citrate synthase is used by all living cells to catalyze the first step of the citric acid cycle. Citric Acid 90-101 citrate synthase Homo sapiens 11-27 21315475-4 2011 The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots. Citric Acid 40-47 citrate synthase Homo sapiens 172-188 21315475-4 2011 The higher concentrations of malate and citrate were accompanied by increased activities of phosphoenolpyruvate carboxylase (PEPC), phosphoenolpyruvate phosphatase (PEPP), citrate synthase (CS) and NAD-malic enzyme (NAD-ME) and decreased activities of pyruvate kinase (PK), NADP-ME and NADP-isocitrate dehydrogenase (NADP-IDH) in roots. Citric Acid 40-47 citrate synthase Homo sapiens 190-192 9381947-5 1997 The trained SCI groups had significantly higher levels of the citric acid cycle marker enzyme citrate synthase (34% and 63%) than the untrained SCI groups and able-bodied subjects, respectively. Citric Acid 62-73 citrate synthase Homo sapiens 94-110 10556622-4 1999 Interestingly, iron also positively affects three other citric acid cycle enzymes, namely citrate synthase, isocitric dehydrogenase, and succinate dehydrogenase, while DFO decreases the activity of these enzymes. Citric Acid 56-67 citrate synthase Homo sapiens 90-106 9037708-1 1997 Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis. Citric Acid 23-30 citrate synthase Homo sapiens 0-16