PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21049082-7 2010 By feeding the cells labeled glutamine, we also detected a "backwards" flux in the tricarboxylic acid cycle from alpha-ketoglutarate to citrate that was enhanced in contact-inhibited fibroblasts; this flux likely contributes to shuttling of NADPH from the mitochondrion to cytosol for redox defense or fatty acid synthesis. Citric Acid 136-143 2,4-dienoyl-CoA reductase 1 Homo sapiens 241-246 31717433-7 2019 This so-called aerobic glycolysis is known as the "Warburg Effect" and serves to provide more anabolic metabolites upstream of the citric acid cycle, such as amino acids, pentoses and NADPH for cancer cell growth. Citric Acid 131-142 2,4-dienoyl-CoA reductase 1 Homo sapiens 184-189 2556968-10 1989 NADH-dependent lipid peroxidation was much lower than the NADPH-catalyzed reaction and showed an opposite response to catalysis by ferric complexes compared to .OH generation as production of thiobarbituric acid-reactive material was increased with ferric-ATP and -citrate, but not with ferric-EDTA or- DTPA, and was not affected by catalase, SOD, or .OH scavengers. Citric Acid 264-272 2,4-dienoyl-CoA reductase 1 Homo sapiens 0-4 32278088-4 2020 While the buildup of NADPH in chloroplasts provides operation of the malate valve leading to establishment of NADH/NAD+ ratios in different cell compartments, the production of NADH by mitochondria drives citrate export by establishing conditions for the operation of the citrate valve. Citric Acid 205-212 2,4-dienoyl-CoA reductase 1 Homo sapiens 21-26 32278088-4 2020 While the buildup of NADPH in chloroplasts provides operation of the malate valve leading to establishment of NADH/NAD+ ratios in different cell compartments, the production of NADH by mitochondria drives citrate export by establishing conditions for the operation of the citrate valve. Citric Acid 272-279 2,4-dienoyl-CoA reductase 1 Homo sapiens 21-26