PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28167750-2 2017 In mammalian cells the central precursor for lipid biosynthesis, cytosolic acetyl CoA (Ac-CoA), is produced by ATP-citrate lyase (ACLY) from mitochondria-derived citrate or by acetyl-CoA synthetase short-chain family member 2 (ACSS2) from acetate. Citric Acid 115-122 ATP citrate lyase Homo sapiens 130-134 28059952-3 2017 RECENT FINDINGS: ACLY is a critical enzyme linking glucose catabolism to lipogenesis by providing acetyl-CoA from mitochondrial citrate for fatty acid and cholesterol biosynthesis. Citric Acid 128-135 ATP citrate lyase Homo sapiens 17-21 27912843-5 2016 Strategies aiming to increase cytosolic citrate should be developed and tested in humans, knowing that experimental studies have shown that administration of citrate and/or inhibition of ACLY arrest tumor growth, inhibit the expression of the key anti-apoptotic factor Mcl-1, reverse cell dedifferentiation and increase sensibility to cisplatin. Citric Acid 40-47 ATP citrate lyase Homo sapiens 187-191 25701462-1 2015 ATP citrate lyase (ACLY) is responsible for the conversion of cytosolic citrate into acetyl-CoA and oxaloacetate, and the first rate-limiting enzyme involved in de novo lipogenesis. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 26039450-2 2015 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes mitochondria-derived citrate into oxaloacetate and acetyl-CoA. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-22 25619261-6 2015 Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase. Citric Acid 79-86 ATP citrate lyase Homo sapiens 37-54 25619261-6 2015 Tricarballylic acid, an inhibitor of ATP-citrate lyase, blocked the ability of citrate to augment TNF-alpha, linking citrate"s augmentation effect with its metabolism by ATP-citrate lyase. Citric Acid 79-86 ATP citrate lyase Homo sapiens 170-187 25537655-1 2015 ATP citrate lyase (ACLY), an important enzyme involved in lipid biogenesis linked with glucose metabolism, catalyzes the conversion of citrate to oxaloacetic acid (OAA) and acetyl-CoA. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 25511512-5 2015 We also compared the effects of CTP inhibition with ACLY and found that the inhibition of ACLY reduced cytoplasmic citrate levels and limited cell viability more effectively than CTP inhibition. Citric Acid 115-122 ATP citrate lyase Homo sapiens 90-94 21170889-6 2010 Acid-base status is the most important physiological determinant of urinary citrate excretion, by modulating the activities of NaDC1 and cytoplasmic (ATP citrate lyase) and mitochondrial (m-aconitase) enzymes involved in citrate metabolism. Citric Acid 76-83 ATP citrate lyase Homo sapiens 150-167 25367309-1 2015 ATP citrate lyase (ACLY) is a key enzyme that is involved in de novo lipogenesis by catalyzing conversion of cytosolic citrate into acetyl CoA and oxaloacetate. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 22657152-1 2012 ATP citrate lyase (ACL) catalyzes an ATP-dependent biosynthetic reaction which produces acetyl-coenzyme A and oxaloacetate from citrate and coenzyme A (CoA). Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-22 22575446-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes generation of acetyl-CoA from citrate. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 25277207-8 2014 Levels of phosphorylated ATP-citrate Lyase (ACLY) were lower in cell lines expressing mutant CIC-S proteins compared to cells expressing wild type CIC-S, supporting a cytosolic citrate metabolism-related mechanism bof reduced clonogenicity in our in vitro model systems. Citric Acid 29-36 ATP citrate lyase Homo sapiens 44-48 22787121-1 2012 ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 22510345-9 2012 Gene products predicting significantly a reduced citrate level were acetyl citrate lyase (ACLY, P = 0.003) and m-aconitase (ACON, P < 0.001). Citric Acid 49-56 ATP citrate lyase Homo sapiens 68-88 22510345-9 2012 Gene products predicting significantly a reduced citrate level were acetyl citrate lyase (ACLY, P = 0.003) and m-aconitase (ACON, P < 0.001). Citric Acid 49-56 ATP citrate lyase Homo sapiens 90-94 21688263-1 2012 ATP citrate lyase (ACL) catalyzes the conversion of cytosolic citrate to acetyl-CoA and oxaloacetate. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-22 20558738-0 2010 Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography. Citric Acid 22-29 ATP citrate lyase Homo sapiens 52-69 20558738-1 2010 ATP-citrate lyase (ACLY) catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, coupled with the hydrolysis of ATP. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 19286649-1 2009 ATP citrate lyase (ACL) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg(2+) as a necessary cofactor. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-22 19795461-5 2010 The enzyme that breaks down cytosolic citric acid is ATP citrate lyase (ACLY). Citric Acid 38-49 ATP citrate lyase Homo sapiens 53-70 19795461-5 2010 The enzyme that breaks down cytosolic citric acid is ATP citrate lyase (ACLY). Citric Acid 38-49 ATP citrate lyase Homo sapiens 72-76 19286649-8 2009 The current assay consists of 1) incubation of ACL enzyme with [(14)C]citrate and other substrates/cofactors CoA, ATP, and Mg(2+), 2) EDTA quench, 3) addition of MicroScint-O, the agent that specifically detects product [(14)C]acetyl-CoA, and 4) detection of signal by TopCount. Citric Acid 70-77 ATP citrate lyase Homo sapiens 47-50 15733107-0 2005 Effects of potassium-magnesium citrate supplementation on cytosolic ATP citrate lyase and mitochondrial aconitase activity in leukocytes: a window on renal citrate metabolism. Citric Acid 31-38 ATP citrate lyase Homo sapiens 68-85 16226706-4 2005 A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA. Citric Acid 66-73 ATP citrate lyase Homo sapiens 81-84 16007201-5 2005 The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL). Citric Acid 134-141 ATP citrate lyase Homo sapiens 164-181 16007201-5 2005 The net conversion of glucose to lipid is dependent on the ability of cells to produce cytosolic acetyl CoA from mitochondria-derived citrate through the action of ATP citrate lyase (ACL). Citric Acid 134-141 ATP citrate lyase Homo sapiens 183-186 15733107-1 2005 BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase). Citric Acid 35-42 ATP citrate lyase Homo sapiens 123-140 15733107-1 2005 BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase). Citric Acid 35-42 ATP citrate lyase Homo sapiens 142-145 15733107-9 2005 The decrease in ACL activity was inversely correlated with an increase in urinary excretion of both potassium (r = -0.620, P < 0.0001) and citrate (r = -0.451, P < 0.004). Citric Acid 142-149 ATP citrate lyase Homo sapiens 16-19 12367768-8 2002 When data of the two groups were combined, urinary citrate excretion was inversely correlated with leucocyte ACL activity (r = 0.6783, p < 0.001). Citric Acid 51-58 ATP citrate lyase Homo sapiens 109-112 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Citric Acid 80-87 ATP citrate lyase Homo sapiens 38-55 12079877-1 2002 Mammals metabolize citrate to acetyl-CoA and oxaloacetate via the enzyme, ATP:citrate lyase. Citric Acid 19-26 ATP citrate lyase Homo sapiens 74-91 34831186-3 2021 In this context, the metabolic enzyme ATP citrate lyase (ACLY), the producer of citrate-derived acetyl-coenzyme A (CoA), plays a critical role in supporting a proinflammatory response. Citric Acid 80-87 ATP citrate lyase Homo sapiens 57-61 1479587-2 1992 Citric acid analogues (+/-)-12a,b and (+/-)-17a,b, where one of the primary carboxylates has been replaced by a sulfoximinoyl and a 3-(3-hydroxy-beta-lactamyl) moiety, respectively, have been synthesized and evaluated as inhibitors of ATP-citrate lyase. Citric Acid 0-11 ATP citrate lyase Homo sapiens 235-252 34323067-0 2021 Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD. Citric Acid 14-21 ATP citrate lyase Homo sapiens 75-79 34323067-2 2021 Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Citric Acid 12-19 ATP citrate lyase Homo sapiens 130-157 34323067-2 2021 Cytoplasmic citrate flux, mediated by plasma membrane citrate transporter (SLC13A5), mitochondrial citrate carrier (SLC25A1), and ATP-dependent citrate lyase (ACLY), determines the central carbon source for acetyl-CoA required in DNL. Citric Acid 12-19 ATP citrate lyase Homo sapiens 159-163 34323067-8 2021 Besides, curcumin also functionally inhibited both citrate transport and metabolism mediated by SLC13A5 and ACLY, respectively. Citric Acid 51-58 ATP citrate lyase Homo sapiens 108-112 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Citric Acid 112-119 ATP citrate lyase Homo sapiens 48-65 34122722-6 2021 CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators. Citric Acid 45-52 ATP citrate lyase Homo sapiens 5-9 34122722-6 2021 CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators. Citric Acid 45-52 ATP citrate lyase Homo sapiens 177-181 34122722-6 2021 CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators. Citric Acid 110-117 ATP citrate lyase Homo sapiens 177-181 34122722-7 2021 We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO , PGE2, and histone acetylation levels. Citric Acid 16-23 ATP citrate lyase Homo sapiens 121-125 34122722-7 2021 We identify the citrate pathway as a RWP target in carrying out its anti-inflammatory activity since RWP reduces CIC and ACLY protein levels, ACLY enzymatic activity, the cytosolic citrate concentration, and in turn ROS, NO , PGE2, and histone acetylation levels. Citric Acid 16-23 ATP citrate lyase Homo sapiens 142-146 35404187-0 2022 Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. Citric Acid 71-78 ATP citrate lyase Homo sapiens 36-40 35404187-0 2022 Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. Citric Acid 71-78 ATP citrate lyase Homo sapiens 42-59 35404187-6 2022 Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation. Citric Acid 110-117 ATP citrate lyase Homo sapiens 31-35 35404187-6 2022 Mechanistically, we found that ACLY (ATP citrate lyase), which is a crucial enzyme catalyzing the cleavage of citrate, was preferentially associated with K63-linked ubiquitin chains and recognized by the autophagy receptor protein SQSTM1/p62 for selective autophagic degradation. Citric Acid 110-117 ATP citrate lyase Homo sapiens 37-54 35404187-9 2022 Collectively, our data reveal that autophagy in granulosa cells is a beneficial mechanism to maintain a certain degree of citrate by selectively targeting ACLY during oocyte maturation. Citric Acid 122-129 ATP citrate lyase Homo sapiens 155-159 35402505-6 2022 To do this, we used genome editing to knock out ATP citrate lyase (ACLY), the enzyme responsible for converting citrate to oxaloacetate and acetyl-CoA in the cytoplasm and nucleus. Citric Acid 112-119 ATP citrate lyase Homo sapiens 67-71 2459580-5 1988 These transformation-associated deviations from the normally high amounts of citrate and low amounts of lipids in the prostate are consistent with an alteration in either the concentration or the activity of ATP-citrate lyase in the tumors. Citric Acid 77-84 ATP citrate lyase Homo sapiens 208-225 35264789-5 2022 Genetic co-essentiality mapping revealed a cluster of genes that is sufficient to compose a biochemical alternative to the canonical TCA cycle, wherein mitochondrially derived citrate exported to the cytoplasm is metabolized by ATP citrate lyase, ultimately regenerating mitochondrial oxaloacetate to complete this non-canonical TCA cycle. Citric Acid 176-183 ATP citrate lyase Homo sapiens 228-245 33282912-6 2020 In HepG2 cells, the expression of ACLY is correlated with histone acetylation, which, in turn, depends on citrate concentration. Citric Acid 106-113 ATP citrate lyase Homo sapiens 34-38 837895-1 1977 In the liver of adult diabetics, the activity of two enzymes of the citrate-cleavage pathway was increased, the change being statistically significant for NADP-malate dehydrogenase (+ 46%, p less than 0.05) but not significant for ATP citrate-lyase (+ 55%, p greater than 0.10). Citric Acid 68-75 ATP citrate lyase Homo sapiens 231-248 1183727-6 1975 Of the citrate cleavage pathway enzymes, ATP citrate-lyase, although having a lower activity than malate dehydrogenase and malate dehydrogenase (decarboxylating) (NADP), was readily measurable, which contrasts with previous data by others. Citric Acid 7-14 ATP citrate lyase Homo sapiens 41-58 236846-2 1975 (b) Of the enzymes of the citrate cleavage pathway, ATP citrate lyase and malate dehydrogenase (decarboxylating) (NADP+) were virtually absent in the cells studied. Citric Acid 26-33 ATP citrate lyase Homo sapiens 52-69 33096779-1 2020 Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels. Citric Acid 7-14 ATP citrate lyase Homo sapiens 141-158 33096779-1 2020 Hydroxycitrate (HCA), a main organic acid component of the fruit rind of Garcinia cambogia, is a natural citrate analog that can inhibit the ATP citrate lyase (ACLY) enzyme with a consequent reduction of inflammatory mediators (i.e., nitric oxide (NO), reactive oxygen species (ROS), and prostaglandin E2 (PGE2)) levels. Citric Acid 7-14 ATP citrate lyase Homo sapiens 160-164 32692565-5 2020 Notably, citrate metabolism and transportation in cell mitochondria were significantly influenced by BBR, which led to the blocked biosynthesis of the defined fatty acids (FAs) through the regulation of ACLY, ACO1 and SLC13A5. Citric Acid 9-16 ATP citrate lyase Homo sapiens 203-207 32849657-9 2020 MICA expression was reduced by inhibitors of mitochondrial function, FCCP and etomoxir e.g., and depended on conversion of citrate to acetyl-CoA and oxaloacetate by ATP citrate lyase, which was also observed in several cancer cell types. Citric Acid 123-130 ATP citrate lyase Homo sapiens 165-182 32448086-1 2021 ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 32448086-3 2021 Since ACLY-mediated conversion of citrate to acetyl-CoA constitutes the basis for fatty acid synthesis, ACLY seems to be quite an unexplored and promising therapeutic target for anticancer drug design. Citric Acid 34-41 ATP citrate lyase Homo sapiens 6-10 32164290-0 2020 Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions. Citric Acid 28-35 ATP citrate lyase Homo sapiens 117-120 32164290-2 2020 ATP-citrate lyase (ACL) and cytosolic aconitase (cyt-ACO) are the two citrate-degrading enzymes that decide the carbon flux towards different metabolite biosynthesis pathways. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-22 32164290-5 2020 The results showed that the correlation between citrate concentration and cyt-ACO or ACL activity varied greatly among cultivars, while the activities of cyt-ACO and ACL had a significantly negative correlation (r = -0.4431). Citric Acid 48-55 ATP citrate lyase Homo sapiens 85-88 32164290-8 2020 Taken together, the present study suggested that ACL and cyt-ACO synergistically control the citrate fate for the biosynthesis of other metabolites, but they are not the key determinants for the accumulation of citrate, as well as other metabolites in citrus fruits. Citric Acid 93-100 ATP citrate lyase Homo sapiens 49-52 31873304-5 2020 The structure of a catalytic mutant of ACLY in the presence of ATP, citrate and CoA substrates reveals a phospho-citryl-CoA intermediate in the ASH domain. Citric Acid 68-75 ATP citrate lyase Homo sapiens 39-43 31947614-1 2020 The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. Citric Acid 126-133 ATP citrate lyase Homo sapiens 63-80 31947614-1 2020 The Drosophila melanogaster DmATPCL gene encodes for the human ATP Citrate Lyase (ACL) ortholog, a metabolic enzyme that from citrate generates glucose-derived Acetyl-CoA, which fuels central biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of proteins and histones. Citric Acid 126-133 ATP citrate lyase Homo sapiens 82-85 31150280-2 2019 Here we showed that ATP-citrate lyase (ACL), an enzyme converting citrate to acetyl-CoA, is highly induced in the kidney of overweight or obese patients with CKD and ob/ob BTBR mice. Citric Acid 24-31 ATP citrate lyase Homo sapiens 39-42 31499095-1 2020 ATP citrate lyase (ACLY) is an important enzyme linking carbohydrate to lipid metabolism by generating acetyl-CoA from citrate for fatty acid and cholesterol biosynthesis. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 31411782-1 2019 ATP-citrate lyase (ACLY) catalyzes production of acetyl-CoA and oxaloacetate from CoA and citrate using ATP. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 31019471-7 2019 Interestingly, depletion of ATPCL drastically increased the frequency of chromosome breaks (CBs) associated to mutations in scheggia, which encodes the ortholog of the mitochondrial citrate carrier SLC25A1 that is also required for chromosome integrity and histone acetylation. Citric Acid 182-189 ATP citrate lyase Homo sapiens 28-33 31019471-8 2019 Our results indicate that ATPCL has a dispensable role in histone acetylation and prevents massive chromosome fragmentation when citrate efflux is altered. Citric Acid 129-136 ATP citrate lyase Homo sapiens 26-31 30586346-3 2019 RECENT FINDINGS: The liver-specific activation of bempedoic acid inhibits ACLY, a key enzyme linking glucose catabolism to lipogenesis by catalyzing the formation of acetyl-CoA from mitochondrial-derived citrate for de novo synthesis of fatty acids and cholesterol. Citric Acid 204-211 ATP citrate lyase Homo sapiens 74-78 30944472-1 2019 ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1-5. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 30944476-1 2019 Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA1. Citric Acid 39-46 ATP citrate lyase Homo sapiens 54-58 29745322-3 2019 In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase. Citric Acid 24-31 ATP citrate lyase Homo sapiens 265-282 29745322-3 2019 In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase. Citric Acid 85-92 ATP citrate lyase Homo sapiens 265-282 29745322-3 2019 In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase. Citric Acid 85-92 ATP citrate lyase Homo sapiens 265-282 29745322-3 2019 In this context most of citrate is diverted from Krebs cycle and channeled into the "citrate pathway" consisting in the increase of the export of citrate into cytosol by the mitochondrial citrate carrier followed by its cleavage into acetyl-CoA and oxaloacetate by ATP citrate lyase. Citric Acid 85-92 ATP citrate lyase Homo sapiens 265-282 29745322-7 2019 Inhibition of CIC or ACLY by different synthetic and natural molecules results in reduction of NO, ROS and PGE2 levels suggesting that the citrate pathway can be a new target to be addressed in inflammation. Citric Acid 139-146 ATP citrate lyase Homo sapiens 21-25 30195238-1 2018 ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Citric Acid 4-11 ATP citrate lyase Homo sapiens 19-23 30195238-4 2018 Once transported to the cytosol, citrate is here converted by ACLY to acetyl-CoA, an essential biosynthetic precursor for fatty acid synthesis and mevalonate pathway. Citric Acid 33-40 ATP citrate lyase Homo sapiens 62-66 29929979-3 2018 Hence, we studied chondrocyte ATP-citrate lyase (ACLY), which generates acetyl-CoA from mitochondrial-derived citrate, and modulates acetylation of histones and transcription factors. Citric Acid 34-41 ATP citrate lyase Homo sapiens 49-53 30050389-3 2018 Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). Citric Acid 0-7 ATP citrate lyase Homo sapiens 216-233 30050389-3 2018 Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). Citric Acid 0-7 ATP citrate lyase Homo sapiens 235-239 30050389-3 2018 Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). Citric Acid 126-133 ATP citrate lyase Homo sapiens 216-233 30050389-3 2018 Citrate is an intermediary metabolite synthesized in mitochondria, and when transported into the cytosol by the mitochondrial citrate carrier-SLC25A1-encoded protein-it is cleaved into acetyl-CoA and oxaloacetate by ATP citrate lyase (ACLY). Citric Acid 126-133 ATP citrate lyase Homo sapiens 235-239 30050389-11 2018 Therefore, SLC25A1 and ACLY upregulation suggests that metabolic reprogramming in BS involves the citrate pathway dysregulation. Citric Acid 98-105 ATP citrate lyase Homo sapiens 23-27