PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24819048-5 2014 In the present study, we demonstrate in vitro direct functional activation of TRPA1 receptor by citric acid which is routinely used to evoke cough in preclinical and clinical studies. Citric Acid 96-107 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 78-83 24819048-6 2014 We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs. Citric Acid 96-107 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 60-65 24819048-6 2014 We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs. Citric Acid 96-107 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 142-147 24819048-6 2014 We also show for the first time that a potent and selective TRPA1 antagonist GRC 17536 inhibits citric acid induced cellular Ca(+2) influx in TRPA1 expressing cells and the citric acid induced cough response in guinea pigs. Citric Acid 173-184 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 60-65 24819048-7 2014 Hence our data provides a mechanistic link between TRPA1 receptor activation in vitro and cough response induced in vivo by citric acid. Citric Acid 124-135 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 51-56