PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32713659-1 2020 BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate. Citric Acid 165-172 aconitase 2 Homo sapiens 16-20 33676027-12 2021 Specifically, blockade of ACO2 caused reduction in TCA cycle intermediates and suppression of mitochondrial oxidative phosphorylation, resulting in increase of glycolysis and elevated citrate flux for fatty acid and lipid synthesis. Citric Acid 184-191 aconitase 2 Homo sapiens 26-30 33676027-13 2021 Increased citrate flux was able to induce upregulation of stearoyl-CoA desaturase (SCD1), which enhanced lipid desaturation in ACO2-deficent cells to favor colorectal cancer growth. Citric Acid 10-17 aconitase 2 Homo sapiens 127-131 33115805-3 2021 ACO2 promoted mitochondrial citrate synthesis to facilitate de novo lipogenesis, and genetic ablation of ACO2 reduced total lipid content and severely repressed in vivo prostate cancer progression. Citric Acid 28-35 aconitase 2 Homo sapiens 0-4 32713659-1 2020 BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate. Citric Acid 165-172 aconitase 2 Homo sapiens 34-57 23709747-3 2013 Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate. Citric Acid 153-160 aconitase 2 Homo sapiens 0-23 31819175-2 2020 Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far. Citric Acid 63-70 aconitase 2 Homo sapiens 0-11 31819175-2 2020 Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far. Citric Acid 63-70 aconitase 2 Homo sapiens 13-17 30972978-3 2019 In prostate cancer, cells undergo metabolic transformation from zinc-accumulating, citrate-producing cells to citrate-oxidizing malignant cells with lower zinc levels and higher mitochondrial aconitase (ACO2) activity. Citric Acid 110-117 aconitase 2 Homo sapiens 178-201 30972978-3 2019 In prostate cancer, cells undergo metabolic transformation from zinc-accumulating, citrate-producing cells to citrate-oxidizing malignant cells with lower zinc levels and higher mitochondrial aconitase (ACO2) activity. Citric Acid 110-117 aconitase 2 Homo sapiens 203-207 30972978-4 2019 ACO2 is a Krebs cycle enzyme that converts citrate to isocitrate and is sensitive to reactive oxygen species (ROS)-mediated damage. Citric Acid 43-50 aconitase 2 Homo sapiens 0-4 30689204-1 2019 Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2. Citric Acid 117-124 aconitase 2 Homo sapiens 0-23 30689204-1 2019 Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2. Citric Acid 117-124 aconitase 2 Homo sapiens 173-177 29318542-1 2018 Mitochondrial aconitase is a reversible enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle. Citric Acid 80-87 aconitase 2 Homo sapiens 0-23 32449285-1 2020 The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle. Citric Acid 91-98 aconitase 2 Homo sapiens 4-27 32449285-1 2020 The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle. Citric Acid 91-98 aconitase 2 Homo sapiens 34-38 25634685-14 2015 Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p < 0.05). Citric Acid 64-71 aconitase 2 Homo sapiens 0-21 25634685-14 2015 Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p < 0.05). Citric Acid 64-71 aconitase 2 Homo sapiens 23-27 25351951-4 2014 RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate. Citric Acid 206-213 aconitase 2 Homo sapiens 109-132 25351951-4 2014 RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate. Citric Acid 206-213 aconitase 2 Homo sapiens 134-138 23709747-3 2013 Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate. Citric Acid 153-160 aconitase 2 Homo sapiens 33-38 23709747-3 2013 Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate. Citric Acid 190-201 aconitase 2 Homo sapiens 0-23 23709747-3 2013 Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate. Citric Acid 190-201 aconitase 2 Homo sapiens 33-38 12198595-5 2002 The key regulatory enzymes directly associated with citrate production in the prostate cells are mitochondrial aspartate aminotransferase, pyruvate dehydrogenase, and mitochondrial aconitase. Citric Acid 52-59 aconitase 2 Homo sapiens 167-190 23550275-2 2013 Aconitase (ACO2) is an essential enzyme located in the mitochondria and catalyzes the interconversion of citrate and isocitrate in the tricarboxylic acid cycle. Citric Acid 105-112 aconitase 2 Homo sapiens 11-15 16201454-1 2005 Mitochondrial aconitase (mACON) is the key enzyme for the citrate oxidation in the mitochondrial Krebs cycle. Citric Acid 58-65 aconitase 2 Homo sapiens 0-23 15149735-1 2004 Mitochondrial aconitase (mACON) is regarded as the key enzyme for citrate oxidation in human prostatic epithelial cells. Citric Acid 66-73 aconitase 2 Homo sapiens 0-23 12730455-8 2003 The changes in m-acon synthesis and abundance in liver during iron deficiency fail to affect TCA-cycle capacity but are associated with a significant upregulation of mitochondrial export of radiolabeled citrate. Citric Acid 203-210 aconitase 2 Homo sapiens 15-21 20607720-1 2011 BACKGROUND: Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate. Citric Acid 77-84 aconitase 2 Homo sapiens 12-35 17205209-3 2007 Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1). Citric Acid 139-150 aconitase 2 Homo sapiens 108-131 16094633-1 2006 Mitochondrial aconitase (mACON) contains a [4Fe-4S] cluster as the key enzyme for citrate oxidation in the human prostatic epithelial cell. Citric Acid 82-89 aconitase 2 Homo sapiens 0-23 15733107-0 2005 Effects of potassium-magnesium citrate supplementation on cytosolic ATP citrate lyase and mitochondrial aconitase activity in leukocytes: a window on renal citrate metabolism. Citric Acid 31-38 aconitase 2 Homo sapiens 90-113 15733107-1 2005 BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase). Citric Acid 35-42 aconitase 2 Homo sapiens 151-174 15733107-1 2005 BACKGROUND: An increase in urinary citrate excretion is associated with a decrease in activity of renal cortical cytosolic ATP citrate lyase (ACL) and mitochondrial aconitase (m-aconitase). Citric Acid 35-42 aconitase 2 Homo sapiens 176-187 15733107-10 2005 A similar inverse correlation was observed between m-aconitase activity and urinary excretion of citrate (r = -0.322, P < 0.043). Citric Acid 97-104 aconitase 2 Homo sapiens 51-62 15543948-1 2004 The mitochondrial aconitase (mACON) containing a [4Fe-4S] cluster is regarded as the key enzyme for citrate oxidation in the epithelial cells of human prostate. Citric Acid 100-107 aconitase 2 Homo sapiens 4-27 14972331-1 2004 A bioenergetic theory of prostate malignancy proposed that normal citrate-producing prostate epithelial cell become citrate-oxidizing cells, in which mitochondrial aconitase (mACON) is not limiting, providing the energy required for the onset and progression of malignancy and metastasis. Citric Acid 116-123 aconitase 2 Homo sapiens 150-173 10799480-2 2000 Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle. Citric Acid 150-157 aconitase 2 Homo sapiens 0-23 10799480-2 2000 Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle. Citric Acid 150-157 aconitase 2 Homo sapiens 25-36 8994263-4 1997 The finding of an IRE in the citric acid cycle enzymes, mitochondrial aconitase and succinate dehydrogenase, suggests that the IRPs may also influence cellular energy production. Citric Acid 29-40 aconitase 2 Homo sapiens 56-79 9326580-4 1997 Utilizing an immunochemical probe for oxidatively modified proteins, we show that mitochondrial aconitase, an enzyme in the citric acid cycle, is a specific target during aging of the housefly. Citric Acid 124-135 aconitase 2 Homo sapiens 82-105 9073575-2 1997 More specifically, the activity of two [Fe-S] enzymes was followed during the course of NO synthase expression:mitochondrial aconitase, which catalyzes citrate:isocitrate conversion in the Krebs cycle, and cytoplasmic aconitase, or iron regulatory protein (IRP), a trans-regulator that controls expression at the posttranscriptional level of proteins involved in iron metabolism. Citric Acid 152-159 aconitase 2 Homo sapiens 111-134 10631981-1 1999 The crystal structure of the S642A mutant of mitochondrial aconitase (mAc) with citrate bound has been determined at 1.8 A resolution and 100 K to capture this binding mode of substrates to the native enzyme. Citric Acid 80-87 aconitase 2 Homo sapiens 45-68 1324911-1 1992 We have obtained iron K-edge extended x-ray absorption fine structure spectra of the plant mitochondrial aconitase in its active state, in the presence (aconitase (+)) and absence (aconitase (-)) of the substrate citrate. Citric Acid 213-220 aconitase 2 Homo sapiens 91-114 8798666-9 1996 Thus, expression of the iron-sulfur protein mitochondrial aconitase and function of the citric acid cycle may be regulated by iron levels in cells. Citric Acid 88-99 aconitase 2 Homo sapiens 44-67 8682202-2 1996 More recently, IRP-1 was found to represent the functional cytoplasmic homologue of mitochondrial aconitase, a citric acid cycle enzyme. Citric Acid 111-122 aconitase 2 Homo sapiens 84-107