PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2870898-4	1986	It is likely, therefore, that the mechanism of action of these compounds is the same as that for allylisopropylacetamide (AIA) and related monosubstituted olefins, which are converted by cytochrome P-450 to chemically reactive species which bind covalently to the prosthetic heme moiety of the cytochrome and thereby destroy the enzyme.	Alkenes	155-162	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	187-203	
2870898-6	1986	These findings, together with data from related metabolic studies on AIA, support the view that the efficiency of the initial double bond oxidation reaction determines the extent of cytochrome P-450 destruction during the metabolism of terminal olefins, rather than any subsequent step.	Alkenes	245-252	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	182-198	
6652073-0	1983	Olefin oxidation by cytochrome P-450: evidence for group migration in catalytic intermediates formed with vinylidene chloride and trans-1-phenyl-1-butene.	Alkenes	0-6	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-36	
6833252-2	1983	Hepatic microsomal cytochrome P-450 from phenobarbital-pretreated rats is inactivated during the metabolism of linear olefins (ethylene, propene, and octene) and acetylenes (acetylene, propyne, and octyne).	Alkenes	118-125	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	19-35	
8735469-0	1996	CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver.	Alkenes	49-55	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-3	
3101178-4	1987	Desaturation of a nonactivated alkyl substituent represents a novel metabolic function of cytochrome P-450 and probably proceeds via the conversion of substrate to a transient free radical intermediate, which partitions between recombination (alcohol formation) and elimination (olefin production) pathways.	Alkenes	279-285	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	90-106	
8735469-13	1996	The data indicate that (1) several CYP families (CYP2A, CYP2B, CYP2D and CYP3A) could be responsible for the hepatic metabolism of 2-EHA, (2) the same metabolites were formed in rats and man and (3) an unsaturated terminal olefin, 2-ethyl-5-hexenoic acid is formed in the liver.	Alkenes	223-229	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	35-38