PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21382015-0 2011 The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1. Dimethyl Fumarate 33-50 heme oxygenase 1 Homo sapiens 89-105 21382015-2 2011 DMF modifies glutathione (GSH) levels that can induce expression of the anti-inflammatory protein HO-1 (haem oxygenase-1). Dimethyl Fumarate 0-3 heme oxygenase 1 Homo sapiens 98-120 20961405-0 2010 DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1. Dimethyl Fumarate 0-3 heme oxygenase 1 Homo sapiens 90-106 33803289-7 2021 The DMF treatment was associated with no changes in virus replication; higher expressions of the antioxidant enzymes NQO1, GPX1, and HO-1 in the brain and PRDX1 and HO-2 in the spleen; lower levels of 8-OHdG and 3NT; a lower optical redox ratio. Dimethyl Fumarate 4-7 heme oxygenase 1 Homo sapiens 133-137 17235328-0 2007 Dimethylfumarate induces immunosuppression via glutathione depletion and subsequent induction of heme oxygenase 1. Dimethyl Fumarate 0-16 heme oxygenase 1 Homo sapiens 97-113 17235328-7 2007 Supplementation with exogenous glutathione (GSH), which is known to bind DMF, prevented both HO-1 induction as well as the anti-inflammatory effects of DMF. Dimethyl Fumarate 73-76 heme oxygenase 1 Homo sapiens 93-97 17235328-9 2007 These results suggest that DMF acts as active compound within the FAE mixture and at least partially mediates its immunomodulatory activity by the induction of the anti-inflammatory stress protein HO-1 ascribed to the functional depletion of reduced GSH. Dimethyl Fumarate 27-30 heme oxygenase 1 Homo sapiens 197-201 34754326-0 2021 Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration. Dimethyl Fumarate 0-17 heme oxygenase 1 Homo sapiens 92-96 34754326-11 2021 Conclusion: Our data suggested that treatment with DMF mitigated LPS-induced oxidative stress, inflammation, and ER stress-associated apoptosis in NPCs via the Nrf2/HO-1 signaling pathway, thus reliving LPS-induced dysfunction of NPCs, which offered a novel potential pharmacological treatment strategy for IVDD. Dimethyl Fumarate 51-54 heme oxygenase 1 Homo sapiens 165-169 33333908-0 2020 Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure. Dimethyl Fumarate 48-65 heme oxygenase 1 Homo sapiens 6-22 34426902-10 2021 Moreover, the expression of HO-1 and NQO-1 was upregulated in hASCs pretreated with DMF which confirms the activation of the Nrf2 pathway. Dimethyl Fumarate 84-87 heme oxygenase 1 Homo sapiens 28-32 33396673-0 2020 Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway. Dimethyl Fumarate 0-17 heme oxygenase 1 Homo sapiens 118-122 33396673-1 2020 This study aimed to verify whether dimethyl fumarate (DMF) promotes the survival of retinal ganglion cells (RGCs) after optic nerve crush (ONC) accompanied by activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dimethyl Fumarate 35-52 heme oxygenase 1 Homo sapiens 207-223 33396673-1 2020 This study aimed to verify whether dimethyl fumarate (DMF) promotes the survival of retinal ganglion cells (RGCs) after optic nerve crush (ONC) accompanied by activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dimethyl Fumarate 35-52 heme oxygenase 1 Homo sapiens 225-229 33396673-1 2020 This study aimed to verify whether dimethyl fumarate (DMF) promotes the survival of retinal ganglion cells (RGCs) after optic nerve crush (ONC) accompanied by activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dimethyl Fumarate 54-57 heme oxygenase 1 Homo sapiens 207-223 33396673-1 2020 This study aimed to verify whether dimethyl fumarate (DMF) promotes the survival of retinal ganglion cells (RGCs) after optic nerve crush (ONC) accompanied by activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dimethyl Fumarate 54-57 heme oxygenase 1 Homo sapiens 225-229 33396673-3 2020 Furthermore, immunohistochemical and immunoblotting analyses were performed to study the activation of the Nrf2/HO-1 pathway using retinas treated with daily administration of DMF. Dimethyl Fumarate 176-179 heme oxygenase 1 Homo sapiens 112-116 33396673-5 2020 Immunohistochemical analysis showed that DMF administration increased the immunoreactivity for Nrf2 and HO-1, a potent antioxidant enzyme, in RGCs immunolabeled with RNA-binding protein with multiple splicing (RBPMS). Dimethyl Fumarate 41-44 heme oxygenase 1 Homo sapiens 104-108 33396673-6 2020 Immunoblotting analysis revealed an increase in the nuclear expression of Nrf2 and marked upregulation of HO-1 after DMF administration. Dimethyl Fumarate 117-120 heme oxygenase 1 Homo sapiens 106-110 33333908-0 2020 Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure. Dimethyl Fumarate 48-65 heme oxygenase 1 Homo sapiens 24-28 33333908-1 2020 Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate (DMF) structure are reported in this paper. Dimethyl Fumarate 48-65 heme oxygenase 1 Homo sapiens 6-22 33333908-1 2020 Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate (DMF) structure are reported in this paper. Dimethyl Fumarate 48-65 heme oxygenase 1 Homo sapiens 24-28 33333908-1 2020 Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate (DMF) structure are reported in this paper. Dimethyl Fumarate 67-70 heme oxygenase 1 Homo sapiens 6-22 33333908-1 2020 Novel heme oxygenase-1 (HO-1) inducers based on dimethyl fumarate (DMF) structure are reported in this paper. Dimethyl Fumarate 67-70 heme oxygenase 1 Homo sapiens 24-28 33199994-9 2020 DMF also increased the anti-inflammatory and antioxidative ability of NP cells by promoting the activity of the Nrf2/HO-1 and PI3K/Akt signaling pathways, thus delaying IVDD. Dimethyl Fumarate 0-3 heme oxygenase 1 Homo sapiens 117-121 26783548-5 2016 RESULTS: Monocytes from multiple sclerosis (MS) patients receiving DMF had reduced expression of the proinflammatory micro-RNA miR-155 and of antioxidant genes HMOX1 and OSGIN1 compared to untreated MS patients; similar changes were observed in patients receiving FTY720 and/or natalizumab. Dimethyl Fumarate 67-70 heme oxygenase 1 Homo sapiens 160-165 28990726-7 2018 Moreover, DMF was able to induce an activation of manganese superoxide dismutase (MnSOD) and heme-oxygenase-1 (HO-1), decreasing the severity of oxidative stress. Dimethyl Fumarate 10-13 heme oxygenase 1 Homo sapiens 93-109 29209333-7 2017 In addition, DMF treatment upregulated antioxidant enzymes heme oxygenase-1 and glutathione S-transferase-alpha1 expressions. Dimethyl Fumarate 13-16 heme oxygenase 1 Homo sapiens 59-112 28633807-0 2017 Differential induction of ATF3 and HO-1 in myeloid cells and keratinocytes via Dimethylfumarate or Cyclosporine A. Dimethyl Fumarate 79-95 heme oxygenase 1 Homo sapiens 35-39 32553625-8 2020 We also found that DMF inhibited the extracellular release of high mobility group box 1, associated with an up-regulation of heme oxygenase-1, likely mediated through Nrf2 activation. Dimethyl Fumarate 19-22 heme oxygenase 1 Homo sapiens 125-141 28156185-7 2017 RESULTS: DMF and MMF induced NQO1 and HO1 gene expression in ex vivo-stimulated PBMCs, DMF being the more potent inducer. Dimethyl Fumarate 9-12 heme oxygenase 1 Homo sapiens 38-41 26783548-6 2016 In vitro addition of DMF but not MMF to MDMs and microglia inhibited lipopolysaccharide-induced production of inflammatory cytokines and increased expression of the antioxidant gene HMOX1 in the absence of significant cytotoxicity. Dimethyl Fumarate 21-24 heme oxygenase 1 Homo sapiens 182-187 25202977-7 2014 In contrast, increasing HO-1 expression through siRNA derepression or with nonselective pharmacologic inducers, including the CNS-penetrating drug dimethyl fumarate (DMF), decreased supernatant glutamate and neurotoxicity. Dimethyl Fumarate 147-164 heme oxygenase 1 Homo sapiens 24-28 25303683-4 2015 At 20% O2, DMF induced a stronger antioxidant response compared to 5% O2 as evidenced by a higher expression of heme oxygenase-1, NAD(P)H:quinone oxydoreductase-1 and superoxide dismutase-2. Dimethyl Fumarate 11-14 heme oxygenase 1 Homo sapiens 112-189 25202977-7 2014 In contrast, increasing HO-1 expression through siRNA derepression or with nonselective pharmacologic inducers, including the CNS-penetrating drug dimethyl fumarate (DMF), decreased supernatant glutamate and neurotoxicity. Dimethyl Fumarate 166-169 heme oxygenase 1 Homo sapiens 24-28