PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33199994-8 2020 DMF also increased the activity of the nuclear factor erythroid 2-related factor (Nrf) 2/heme oxygenase (HO)-1 signaling pathway in NP cells and increased the phosphorylation of Akt. Dimethyl Fumarate 0-3 AKT serine/threonine kinase 1 Homo sapiens 178-181 33199994-9 2020 DMF also increased the anti-inflammatory and antioxidative ability of NP cells by promoting the activity of the Nrf2/HO-1 and PI3K/Akt signaling pathways, thus delaying IVDD. Dimethyl Fumarate 0-3 AKT serine/threonine kinase 1 Homo sapiens 131-134 32816241-6 2020 PI3K substrate Akt (at Ser473) as well as Wnt dependent beta-catenin and cyclin D1 activity was found to be upregulated by DMF pretreatment in Abeta1-42 treated cells. Dimethyl Fumarate 123-126 AKT serine/threonine kinase 1 Homo sapiens 15-18 32816241-9 2020 These results indicate that down-regulation of GSK-3beta activity and subsequent activation of PI3K/Akt and Wnt/beta-catenin signaling pathways are closely involved in the shielding effect of DMF against Abeta1-42-induced tau hyperphosphorylation. Dimethyl Fumarate 192-195 AKT serine/threonine kinase 1 Homo sapiens 100-103 28870693-10 2018 Together, our work demonstrates a mechanism of the antifibrotic effect of DMF via inhibition of Akt1/GSK3beta/TAZ/YAP signaling and confirms a critical role of TAZ/YAP in mediating the profibrotic responses in dermal fibroblasts. Dimethyl Fumarate 74-77 AKT serine/threonine kinase 1 Homo sapiens 96-100 35141161-0 2022 Dimethyl Fumarate Combined With Vemurafenib Enhances Anti-Melanoma Efficacy via Inhibiting the Hippo/YAP, NRF2-ARE, and AKT/mTOR/ERK Pathways in A375 Melanoma Cells. Dimethyl Fumarate 0-17 AKT serine/threonine kinase 1 Homo sapiens 120-123 28870693-4 2018 Mechanistically, we found that DMF treatment reduced nuclear localization of transcriptional coactivator with PDZ binding motif (TAZ) and Yes-associated protein (YAP) proteins via inhibition of the phosphatidylinositol 3 kinase/protein kinase B (Akt) pathway. Dimethyl Fumarate 31-34 AKT serine/threonine kinase 1 Homo sapiens 246-249 28870693-5 2018 In addition, DMF abrogated TGFbeta/Akt1 mediated inhibitory phosphorylation of glycogen kinase 3beta (GSK3beta) and a subsequent beta-transducin repeat-containing proteins (betaTRCP) mediated proteasomal degradation of TAZ, as well as a corresponding decrease of TAZ/YAP transcriptional targets. Dimethyl Fumarate 13-16 AKT serine/threonine kinase 1 Homo sapiens 35-39 33922540-4 2021 The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients. Dimethyl Fumarate 154-171 AKT serine/threonine kinase 1 Homo sapiens 75-79 33922540-4 2021 The results suggest that polymorphisms detected in the GSTP1, ITGA4, NQO1, AKT1, and GP6 genes, for treatment with natalizumab, ZMIZ1, for fingolimod and dimethyl fumarate, ADA, for cladribine, and NOX3, for dimethyl fumarate, may be used in the future as predictive markers of treatment response to new therapies in MS patients. Dimethyl Fumarate 208-225 AKT serine/threonine kinase 1 Homo sapiens 75-79