PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23916696-9	2013	A role for HDACs in mediating DMF actions is suggested by findings that the selective HDAC inhibitor SAHA increased nuclear Nrf2:DNA binding activity, reduced inflammatory activation of astrocytes which was reversed by a selective inhibitor of the Nrf2 target gene heme-oxygenase 1.	Dimethyl Fumarate	30-33	heme oxygenase 1	Rattus norvegicus	265-281	
20347008-7	2010	After removal of DMF, OLN-93 cells completely restored their cellular glutathione content and strongly upregulated heme oxygenase 1.	Dimethyl Fumarate	17-20	heme oxygenase 1	Rattus norvegicus	115-131	
30472152-14	2019	DMF treatment increased the gene expression of Nrf2, HO-1, NQO1, Bcl-2 and protein expression of Nrf2 and Bcl2.	Dimethyl Fumarate	0-3	heme oxygenase 1	Rattus norvegicus	53-57	
35559248-10	2022	Moreover, DMF exerted its protective effects against DOX by promoting Nrf2 nuclear translocation, which activated its downstream antioxidant gene Hmox1.	Dimethyl Fumarate	10-13	heme oxygenase 1	Rattus norvegicus	146-151	
33745959-9	2021	Also, DMF suppressed changes in oxidative stress markers and inflammatory mediators and enhanced Nrf2 and HO-1 levels in CFA-injected rats.	Dimethyl Fumarate	6-9	heme oxygenase 1	Rattus norvegicus	106-110	
33745959-10	2021	These findings indicate that the anti-arthritic activity of DMF may be mediated by the activation of the Nrf2/HO-1 pathway, which reduced oxidative damage and inflammation.	Dimethyl Fumarate	60-63	heme oxygenase 1	Rattus norvegicus	110-114	
33348309-0	2021	Dimethyl fumarate protects against intestinal ischemia/reperfusion lesion: Participation of Nrf2/HO-1, GSK-3beta and Wnt/beta-catenin pathway.	Dimethyl Fumarate	0-17	heme oxygenase 1	Rattus norvegicus	97-101	
31981960-0	2020	Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.	Dimethyl Fumarate	0-17	heme oxygenase 1	Rattus norvegicus	86-90	
31981960-10	2020	Hepatic protection afforded by DMF was mediated by activating Nrf2/HO-1 signaling and increasing GSH and TAC contents.	Dimethyl Fumarate	31-34	heme oxygenase 1	Rattus norvegicus	67-71	
31981960-12	2020	Moreover, CUR potentiated Nrf2/HO-1 signaling induced by DMF with significant suppression in lipid peroxidation.	Dimethyl Fumarate	57-60	heme oxygenase 1	Rattus norvegicus	31-35	
31981960-13	2020	CONCLUSION: We concluded that combining DMF and CUR has more efficient hepatoprotective effects against hepatic-induced IRI via potentiating antioxidant and anti-inflammatory properties mediated by Nrf2/HO-1 pathway.	Dimethyl Fumarate	40-43	heme oxygenase 1	Rattus norvegicus	203-207	
31761320-6	2020	DMF and GLB intervention significantly ameliorated the DEN + TAA-induced alterations in the antioxidant (Nrf2, HO-1, SOD-1, catalase), inflammatory (NF-kappaB, NLRP3, ASC, caspase-1), fibrogenic (TGF-beta1, collagen) and regenerative proliferative stress (GST-p, HGF, c-MET, TGFalpha, EGF, AFP) markers.	Dimethyl Fumarate	0-3	heme oxygenase 1	Rattus norvegicus	111-115	
31513817-9	2019	(2) DMF pretreatment resulted in an increased Nrf2 and HO-1 expression, and enhanced nuclear Nrf2 level in LPS-challenged cells (P < 0.01).	Dimethyl Fumarate	4-7	heme oxygenase 1	Rattus norvegicus	55-59	
31513817-10	2019	(3) Nrf2-siRNA could inhibit DMF-induced enhancement of HO-1 expression and cell viability, and partly abolish DMF-induced reduction of LDH leakage and apoptosis.	Dimethyl Fumarate	29-32	heme oxygenase 1	Rattus norvegicus	56-60	
31513817-11	2019	(4) ERK1/2 inhibitor PD98059 could not only prevent the DMF-induced enhancement of nuclear Nrf2 and HO-1, but also inhibit DMF-induced increase in cell viability.	Dimethyl Fumarate	56-59	heme oxygenase 1	Rattus norvegicus	100-104	
31513817-15	2019	ERK1/2-dependent activation of Nrf2/HO-1 pathway is responsible for DMF-induced cardioprotection via reduction of oxidative stress, improvement of mitochondrial morphology and energy metabolism.	Dimethyl Fumarate	68-71	heme oxygenase 1	Rattus norvegicus	36-40	
34148507-9	2021	Treatment with DMF increased Nrf2, NAD(P)H dehydrogenase-1 and Heme oxygenase-1 and decreased Tumor necrosis factor alpha and Nuclear factor-kappaB density compared with the CCH group (P<0.001).	Dimethyl Fumarate	15-18	heme oxygenase 1	Rattus norvegicus	63-79	
34751118-19	2021	(4) Protein results showed that the GSK-3beta expression in the DMF group was lower than that in all groups, while the expression of Nrf2, HO1 and NQO1 was higher compared to other groups.	Dimethyl Fumarate	64-67	heme oxygenase 1	Rattus norvegicus	139-142	
35247778-6	2022	The latest report shown that DMF ameliorates complete Freund"s adjuvant-induced arthritis in rats through activation of the Nrf2/HO-1 signaling pathway.	Dimethyl Fumarate	29-32	heme oxygenase 1	Rattus norvegicus	129-133	
33745959-0	2021	Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund"s adjuvant-induced arthritis in rats.	Dimethyl Fumarate	49-66	heme oxygenase 1	Rattus norvegicus	23-27	
33459879-11	2021	Nrf2 (p < 0.05) and its downstream targets HO-1 levels (p < 0.01) and NQO1 (p < 0.05) levels were also up-regulated after DMF treatment.	Dimethyl Fumarate	122-125	heme oxygenase 1	Rattus norvegicus	43-47	
29363907-0	2017	Effect of dimethyl fumarate on heme oxygenase-1 expression in experimental allergic encephalomyelitis in rats.	Dimethyl Fumarate	10-27	heme oxygenase 1	Rattus norvegicus	31-47	
29363907-8	2017	The results showed that HO-1 expression, at both the mRNA and protein level, is influenced by DMF administration only at the very beginning of the symptomatic phase of EAE, and not at the peak of clinical symptoms, nor at the end of the relapse.	Dimethyl Fumarate	94-97	heme oxygenase 1	Rattus norvegicus	24-28	
27251510-8	2016	The protective effect of DMF against oxidative stress in vitro was inhibited by zinc protoporphyrin IX, an inhibitor of heme oxygenase-1, but not by buthionine sulfoximine, an inhibitor of glutathione synthesis.	Dimethyl Fumarate	25-28	heme oxygenase 1	Rattus norvegicus	120-136	
27251510-9	2016	These results suggest that the activation of heme oxygenase-1 plays an important role in the protective effect of DMF.	Dimethyl Fumarate	114-117	heme oxygenase 1	Rattus norvegicus	45-61