PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18760191-7	2008	Further, levels of tumor necrosis factor-alpha (TNF-alpha) in serum and culture supernatants of lymph node cells stimulated with ConA or myosin were significantly lower in DMF-treated EAM animals compared with vehicle-treated EAM rats.	Dimethyl Fumarate	172-175	tumor necrosis factor	Rattus norvegicus	19-46	
27142843-11	2016	Moreover, DMF improved the inflammatory milieu in spleens of EAN rats, characterized by downregulation of messenger RNA (mRNA) of IFN-gamma, TNF-alpha, IL-6, and IL-17 and upregulation of mRNA level of IL-4 and IL-10.	Dimethyl Fumarate	10-13	tumor necrosis factor	Rattus norvegicus	141-150	
18760191-7	2008	Further, levels of tumor necrosis factor-alpha (TNF-alpha) in serum and culture supernatants of lymph node cells stimulated with ConA or myosin were significantly lower in DMF-treated EAM animals compared with vehicle-treated EAM rats.	Dimethyl Fumarate	172-175	tumor necrosis factor	Rattus norvegicus	48-57	
18760191-9	2008	CONCLUSIONS: These results show for the first time that DMF ameliorates experimental autoimmune myocarditis and may be acted, at least in part, by interfering with the production of TNF-alpha.	Dimethyl Fumarate	56-59	tumor necrosis factor	Rattus norvegicus	182-191	
15993952-7	2005	DMF and SP attenuated the LPS-induced production and release of TNFalpha, IL-1beta, IL-6 and NO.	Dimethyl Fumarate	0-3	tumor necrosis factor	Rattus norvegicus	64-72	
18405893-7	2008	DMF inhibited TNF-alpha-induced nuclear entry of NF-kappaB in RHEC.	Dimethyl Fumarate	0-3	tumor necrosis factor	Rattus norvegicus	14-23	
32497629-11	2020	Furthermore, protein expression of TNF-alpha and caspase-3 in diabetic aortas was greatly attenuated by DMF administration.	Dimethyl Fumarate	104-107	tumor necrosis factor	Rattus norvegicus	35-44	
34153667-13	2021	And DMF treatment decreased hippocampus IL-1beta, TNF-alpha, and IL-6 pro-inflammatory cytokines concentration, and mediated the NF-kappaB signaling pathway.	Dimethyl Fumarate	4-7	tumor necrosis factor	Rattus norvegicus	50-59	
33348309-8	2021	The DMFU action entailed anti-inflammatory character manifested by down-regulation of expression/content NF-kappaB with subsequent rebating the contents of TNF-alpha, IL-1beta, and P-selectin, as well as MPO activity.	Dimethyl Fumarate	4-8	tumor necrosis factor	Rattus norvegicus	156-165	
34518966-9	2021	Interestingly, DMF enhanced a significant reduction of NO and TNF-alpha production in the treated group.	Dimethyl Fumarate	15-18	tumor necrosis factor	Rattus norvegicus	62-71	
34148507-9	2021	Treatment with DMF increased Nrf2, NAD(P)H dehydrogenase-1 and Heme oxygenase-1 and decreased Tumor necrosis factor alpha and Nuclear factor-kappaB density compared with the CCH group (P<0.001).	Dimethyl Fumarate	15-18	tumor necrosis factor	Rattus norvegicus	94-121	
33459879-9	2021	DMF decreased MDA (p < 0.001), protein carbonyl (PCO) contents (p < 0.001), and acetylcholinesterase (p < 0.01) activities, and inhibited inflammatory markers (TNF-alpha, IL-1beta, NF-kappabeta, and COX-2) levels.	Dimethyl Fumarate	0-3	tumor necrosis factor	Rattus norvegicus	160-169