PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35605433-4	2022	The results showed that DMF suppressed the activation of NLRP3 inflammasome activation in lipopolysaccharide-primed murine bone marrow-derived macrophages upon ATP or nigericin treatment, as evidenced by reduced cleavage of pro-caspase-1, release of mature interleukin-1beta (IL-1beta) and generation of gasdermin D N-terminal fragment (GSDMD-NT).	Dimethyl Fumarate	24-27	interleukin 1 alpha	Mus musculus	276-284	
34507070-6	2021	After treatment of the cells with DMF alone or with polymer carriers, the expression of IL-1beta, IL-6 and TNF-alpha cytokine genes was significantly reduced.	Dimethyl Fumarate	34-37	interleukin 1 alpha	Mus musculus	88-96	
34858398-9	2021	Here we demonstrated that DMF ameliorated LPS and ATP-induced NLRP3 inflammasome activation by reducing IL-1beta, IL-18, caspase-1, and NLRP3 levels, reactive oxygen species formation and damage, and inhibiting pyroptotic cell death in N9 murine microglia via Nrf2/NF-kappaB pathways.	Dimethyl Fumarate	26-29	interleukin 1 alpha	Mus musculus	104-112	
35153737-15	2021	After administration of DMF, SRSs at 7-21 days after SE were significantly decreased, and the number of clasmatodendritic astrocytes, microglia, and the expression of inflammatory factors such as IL-1beta and IL-18 were significantly attenuated.	Dimethyl Fumarate	24-27	interleukin 1 alpha	Mus musculus	196-204