PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31092974-10	2019	Moreover, renal cortical mRNA expression of Nrf2-related genes such as NQO1 increased in DMF groups.	Dimethyl Fumarate	89-92	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	71-75	
10654840-8	1999	DMF and DIS also caused a much greater increase in levels of DT-diaphorase in the intestine, suggesting that 2-hydroxy-1,4-naphthoquinone is activated by this enzyme in the gut.	Dimethyl Fumarate	0-3	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	61-74	
34751118-19	2021	(4) Protein results showed that the GSK-3beta expression in the DMF group was lower than that in all groups, while the expression of Nrf2, HO1 and NQO1 was higher compared to other groups.	Dimethyl Fumarate	64-67	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	147-151	
33459879-11	2021	Nrf2 (p < 0.05) and its downstream targets HO-1 levels (p < 0.01) and NQO1 (p < 0.05) levels were also up-regulated after DMF treatment.	Dimethyl Fumarate	122-125	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	70-74	
31092974-11	2019	This investigation showed that DMF ameliorates CIS-induced renal tubular injury via NQO1-mediated antioxidant mechanisms and reduces the consequent tubulointerstitial fibrosis.	Dimethyl Fumarate	31-34	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	84-88	
25710612-8	2015	The protein expression of NAD(P)H quinone oxidoreductase-1, a major cellular antioxidant and detoxifying enzyme, was significantly enhanced by DMF administration in kidney.	Dimethyl Fumarate	143-146	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	26-58	
15993952-8	2005	In addition, DMF and SP increase both mRNA level and activity of NAD(P)H:quinone reductase (NQO-1), a detoxication enzyme, as well as the cellular glutathione content.	Dimethyl Fumarate	13-16	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	92-97	
12815004-6	2003	Dimethyl fumarate significantly increased NQO1 and GST activities in colon and liver but did not increase UGT activities in these tissues.	Dimethyl Fumarate	0-17	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	42-46	
30472152-14	2019	DMF treatment increased the gene expression of Nrf2, HO-1, NQO1, Bcl-2 and protein expression of Nrf2 and Bcl2.	Dimethyl Fumarate	0-3	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	59-63