PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18602402-0 2008 Divalent metal ion complexes of S100B in the absence and presence of pentamidine. Pentamidine 69-80 S100 calcium binding protein B Homo sapiens 32-37 23264854-0 2012 Structure-Based Discovery of a Novel Pentamidine-Related Inhibitor of the Calcium-Binding Protein S100B. Pentamidine 37-48 S100 calcium binding protein B Homo sapiens 98-103 23264854-1 2012 Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. Pentamidine 38-49 S100 calcium binding protein B Homo sapiens 50-55 23264854-1 2012 Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. Pentamidine 38-49 S100 calcium binding protein B Homo sapiens 120-125 23264854-1 2012 Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. Pentamidine 38-49 S100 calcium binding protein B Homo sapiens 120-125 23264854-1 2012 Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. Pentamidine 88-99 S100 calcium binding protein B Homo sapiens 50-55 23264854-1 2012 Molecular Dynamics simulations of the pentamidine-S100B complex, where two molecules of pentamidine bind per monomer of S100B, were performed in an effort to determine what properties would be desirable in a pentamidine-derived compound as an inhibitor for S100B. Pentamidine 88-99 S100 calcium binding protein B Homo sapiens 50-55 19966562-1 2010 Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma. Pentamidine 0-11 S100 calcium binding protein B Homo sapiens 71-76 19966562-1 2010 Pentamidine is a small molecule inhibitor of the Ca(+)-binding protein S100B and disrupts the S100B-p53 protein-protein interaction; this is thought to restore wild-type p53 tumour suppressor function in melanoma. Pentamidine 0-11 S100 calcium binding protein B Homo sapiens 94-99 32022398-0 2020 Pentamidine niosomes thwart S100B effects in human colon carcinoma biopsies favouring wtp53 rescue. Pentamidine 0-11 S100 calcium binding protein B Homo sapiens 28-33 32022398-2 2020 Being an S100B inhibitor, pentamidine antagonizes S100B-wtp53 interaction, restoring wtp53-mediated pro-apoptotic control in cancer cells in several types of tumours. Pentamidine 26-37 S100 calcium binding protein B Homo sapiens 9-14 32022398-2 2020 Being an S100B inhibitor, pentamidine antagonizes S100B-wtp53 interaction, restoring wtp53-mediated pro-apoptotic control in cancer cells in several types of tumours. Pentamidine 26-37 S100 calcium binding protein B Homo sapiens 50-55 30679569-5 2019 We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury. Pentamidine 137-148 S100 calcium binding protein B Homo sapiens 93-98 30679569-5 2019 We provide evidence that 5-FU induces reactive gliosis and reduction of enteric neurons in a S100B/RAGE/NFkappaB-dependent manner, since pentamidine, a S100B inhibitor, prevented 5-FU-induced neuronal loss, enteric glia activation, intestinal inflammation, oxidative stress and histological injury. Pentamidine 137-148 S100 calcium binding protein B Homo sapiens 152-157 26727270-1 2016 The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. Pentamidine 9-20 S100 calcium binding protein B Homo sapiens 80-85 26727270-3 2016 Structure-activity relationship (SAR) studies were therefore completed here with 23 pentamidine analogues, and X-ray structures of (Ca)S100B inhibitor complexes revealed that the C-terminus of S100B adopts two different conformations, with location of Phe87 and Phe88 being the distinguishing feature and termed the "FF-gate". Pentamidine 84-95 S100 calcium binding protein B Homo sapiens 193-198 26727270-4 2016 For symmetric pentamidine analogues ((Ca)S100B 5a, (Ca)S100B 6b) a channel between sites 1 and 2 on S100B was occluded by residue Phe88, but for an asymmetric pentamidine analogue ((Ca)S100B 17), this same channel was open. Pentamidine 14-25 S100 calcium binding protein B Homo sapiens 41-46 26727270-4 2016 For symmetric pentamidine analogues ((Ca)S100B 5a, (Ca)S100B 6b) a channel between sites 1 and 2 on S100B was occluded by residue Phe88, but for an asymmetric pentamidine analogue ((Ca)S100B 17), this same channel was open. Pentamidine 14-25 S100 calcium binding protein B Homo sapiens 55-60 26727270-4 2016 For symmetric pentamidine analogues ((Ca)S100B 5a, (Ca)S100B 6b) a channel between sites 1 and 2 on S100B was occluded by residue Phe88, but for an asymmetric pentamidine analogue ((Ca)S100B 17), this same channel was open. Pentamidine 14-25 S100 calcium binding protein B Homo sapiens 55-60 26727270-4 2016 For symmetric pentamidine analogues ((Ca)S100B 5a, (Ca)S100B 6b) a channel between sites 1 and 2 on S100B was occluded by residue Phe88, but for an asymmetric pentamidine analogue ((Ca)S100B 17), this same channel was open. Pentamidine 14-25 S100 calcium binding protein B Homo sapiens 55-60 26727270-5 2016 The (Ca)S100B 17 structure illustrates, for the first time, a pentamidine analog capable of binding the "open" form of the "FF-gate" and provides a means to block all three "hot spots" on (Ca)S100B, which will impact next generation (Ca)S100B p53 inhibitor design. Pentamidine 62-73 S100 calcium binding protein B Homo sapiens 8-13 26727270-5 2016 The (Ca)S100B 17 structure illustrates, for the first time, a pentamidine analog capable of binding the "open" form of the "FF-gate" and provides a means to block all three "hot spots" on (Ca)S100B, which will impact next generation (Ca)S100B p53 inhibitor design. Pentamidine 62-73 S100 calcium binding protein B Homo sapiens 192-197 26727270-5 2016 The (Ca)S100B 17 structure illustrates, for the first time, a pentamidine analog capable of binding the "open" form of the "FF-gate" and provides a means to block all three "hot spots" on (Ca)S100B, which will impact next generation (Ca)S100B p53 inhibitor design. Pentamidine 62-73 S100 calcium binding protein B Homo sapiens 192-197 35620168-3 2022 We examined the relevance of S100B and further investigated the potential of S100B-neutralizing small-molecule pentamidine in chronic experimental autoimmune encephalomyelitis. Pentamidine 111-122 S100 calcium binding protein B Homo sapiens 77-82 17713798-6 2007 Additionally, we have tried to explain a mechanism for the action of pentamidine, the best-known S100B ligand, and have proposed two S100B--pentamidine structures. Pentamidine 69-80 S100 calcium binding protein B Homo sapiens 97-102 17713798-6 2007 Additionally, we have tried to explain a mechanism for the action of pentamidine, the best-known S100B ligand, and have proposed two S100B--pentamidine structures. Pentamidine 69-80 S100 calcium binding protein B Homo sapiens 133-138 17713798-6 2007 Additionally, we have tried to explain a mechanism for the action of pentamidine, the best-known S100B ligand, and have proposed two S100B--pentamidine structures. Pentamidine 140-151 S100 calcium binding protein B Homo sapiens 97-102 17713798-6 2007 Additionally, we have tried to explain a mechanism for the action of pentamidine, the best-known S100B ligand, and have proposed two S100B--pentamidine structures. Pentamidine 140-151 S100 calcium binding protein B Homo sapiens 133-138 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 43-54 S100 calcium binding protein B Homo sapiens 79-84 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 43-54 S100 calcium binding protein B Homo sapiens 138-143 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 43-54 S100 calcium binding protein B Homo sapiens 138-143 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 177-188 S100 calcium binding protein B Homo sapiens 79-84 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 177-188 S100 calcium binding protein B Homo sapiens 138-143 15456252-6 2004 An NMR-docked model of one such inhibitor, pentamidine, bound to Ca(2+)-loaded S100B was calculated using intermolecular NOE data between S100B and the drug, and indicates that pentamidine binds into the p53 binding site on S100B defined by helices 3 and 4 and loop 2 (termed the hinge region). Pentamidine 177-188 S100 calcium binding protein B Homo sapiens 138-143 35620168-6 2022 Blockade of S100B by pentamidine protects against oligodendrogenesis impairment and neuroinflammation by reducing astrocyte reactivity and microglia pro-inflammatory phenotype. Pentamidine 21-32 S100 calcium binding protein B Homo sapiens 12-17