PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23546588-5	2013	Quinone toxicity in hepatocytes: CYPs require electrons supplied from NADPH-cytochrome P450 reductase (NPR) during the process of metabolism.	quinone	0-7	cytochrome p450 oxidoreductase	Homo sapiens	70-101	
23546588-5	2013	Quinone toxicity in hepatocytes: CYPs require electrons supplied from NADPH-cytochrome P450 reductase (NPR) during the process of metabolism.	quinone	0-7	cytochrome p450 oxidoreductase	Homo sapiens	103-106	
23546588-6	2013	NPR also provides electrons to quinone compounds, which compete with CYPs over electrons.	quinone	31-38	cytochrome p450 oxidoreductase	Homo sapiens	0-3	
23546588-7	2013	Inhibition of CYPs shifts NPR"s electron flow more to quinones, which accelerates the redox cycle to enhance ROS production and quinone toxicity.	quinone	54-61	cytochrome p450 oxidoreductase	Homo sapiens	26-29	
9101243-4	1995	(c) NADPH-cytochrome P450 reductase-catalyzed activation of products resulting from the quinone/GSH interaction.	quinone	88-95	cytochrome p450 oxidoreductase	Homo sapiens	4-35	
22205152-4	2012	This suggests that the presence of a modified quinone function is the structural factor excluding reductive activation of antitumour anthraquinone derivatives and analogues by CPR.	quinone	46-53	cytochrome p450 oxidoreductase	Homo sapiens	176-179	
15629867-1	2005	9,10-Phenanthraquinone (PQ), a major quinone contained in diesel exhaust particles and atmospheric PM(2.5), undergoes one-electron reduction by flavin enzymes such as NADPH-cytochrome P450 reductase, leading to production of reactive oxygen species in vitro.	quinone	15-22	cytochrome p450 oxidoreductase	Homo sapiens	167-198	
8971136-3	1996	The heterologous expression of CYPOR in V79 cells resulted in increased sensitivity to quinone-type cytotoxins, e.g. duroquinone and menadione, that exert their toxicity primarily through the production of reactive oxygen species during redox cycling.	quinone	87-94	cytochrome p450 oxidoreductase	Homo sapiens	31-36	
6295407-0	1982	Generation of hydroxyl radical by anticancer quinone drugs, carbazilquinone, mitomycin C, aclacinomycin A and adriamycin, in the presence of NADPH-cytochrome P-450 reductase.	quinone	45-52	cytochrome p450 oxidoreductase	Homo sapiens	141-173	
2536625-1	1989	Using ESR and spin-trapping techniques, it was found that synthetic 2-dimethylamino-3-chloro-1,4-naphthoquinone and the natural anticancer quinone daunomycin, when added to a system containing purified NADPH-cytochrome P-450 reductase, NADPH, ferric ions, and oxygen, (i) generated hydroxyl radicals and (ii) caused single-strand scission of supercoiled DNA of the plasmic pBR322.	quinone	104-111	cytochrome p450 oxidoreductase	Homo sapiens	202-234	
3023600-0	1986	Interactions of anticancer quinone drugs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C, with NADPH-cytochrome P-450 reductase, xanthine oxidase and oxygen.	quinone	27-34	cytochrome p450 oxidoreductase	Homo sapiens	110-142	
3023600-1	1986	The properties of the interactions of anticancer quinone drugs, aclacinomycin A, adriamycin, carbazilquinone, and mitomycin C with nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome P-450 reductase and xanthine oxidase under anaerobic and aerobic conditions were studied.	quinone	49-56	cytochrome p450 oxidoreductase	Homo sapiens	131-209	
6295407-9	1982	From these results, the interactions of anticancer quinone drugs with NADPH-cytochrome P-450 reductase and oxygen, and the possible relations of the enzymes to the radical related actions of these drugs are discussed.	quinone	51-58	cytochrome p450 oxidoreductase	Homo sapiens	70-102	
6283813-5	1981	Superoxide production by NADPH-cytochrome P-450 reductase was maximal at a quinone single-electron reduction potential at -200 mV.	quinone	75-82	cytochrome p450 oxidoreductase	Homo sapiens	25-57	
28214631-0	2017	Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.	quinone	13-20	cytochrome p450 oxidoreductase	Homo sapiens	85-88	
34156-0	1979	NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals.	quinone	47-54	cytochrome p450 oxidoreductase	Homo sapiens	0-32