PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19634918-2	2009	The noncovalent binding of the inhibitory flavonoids to alpha-synuclein and the covalent modification by the flavonoid quinone led to the restriction of the conformational changes in this natively unfolded protein and to the stabilization of soluble flavonoid-modified species of alpha-synuclein (monomers and oligomers).	quinone	119-126	synuclein alpha	Homo sapiens	280-295	
17785456-6	2007	Cell-free studies using novel near infrared fluorescence methodology for the detection of covalent protein-ortho-quinone adducts showed that although covalent modification of alpha-syn occurs, this does not affect alpha-syn fibril formation.	quinone	113-120	synuclein alpha	Homo sapiens	175-184	
29030055-11	2019	DOPAL oxidizes spontaneously to DOPAL-quinone, which probably converts alpha-synuclein to its toxic oligomeric form.	quinone	38-45	synuclein alpha	Homo sapiens	71-86	
16008565-4	2005	The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts.	quinone	156-163	synuclein alpha	Homo sapiens	86-95	
16008565-4	2005	The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts.	quinone	156-163	synuclein alpha	Homo sapiens	211-220	
16008565-4	2005	The MS and NMR characterizations strongly demonstrate that DA and its analogs inhibit alpha-Syn fibrillization by a mechanism where the oxidation products (quinones) of DA analogs react with the amino groups of alpha-Syn chain, generating alpha-Syn-quinone adducts.	quinone	156-163	synuclein alpha	Homo sapiens	211-220	
16008565-5	2005	It is likely that the amino groups of alpha-Syn undergo nucleophilic attack on the quinone moiety of DA analogs to form imino bonds.	quinone	83-90	synuclein alpha	Homo sapiens	38-47	
32906170-11	2020	Probably via spontaneous oxidation, DOPAL potently oligomerizes and forms quinone-protein adducts with ("quinonizes") alpha-synuclein (AS), a major constituent in Lewy bodies, and DOPAL-induced AS oligomers impede vesicular storage.	quinone	74-81	synuclein alpha	Homo sapiens	118-133	
11134896-9	2001	We suggest that NAC can perpetuate the redox cycle between the quinone and the semiquinone forms of the catecholestrogens, thereby enhancing the production of ROS.	quinone	63-70	synuclein alpha	Homo sapiens	16-19	
1899328-7	1991	In the present study, we have explored kinetic and mechanistic features of the conversion of NAcDEE to NAc delta DEE and found that the reaction requires: (i) oxidation of NAcDEE to the quinone, (ii) the presence of a Lewis base as a catalyst (phosphate anion was the best of those tried in the pH range 6.0-8.0), and (iii) prevention of competing reactions such as Michael additions.	quinone	186-193	synuclein alpha	Homo sapiens	93-96	
32538547-6	2020	RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples.	quinone	61-68	synuclein alpha	Homo sapiens	21-30	
32538547-6	2020	RESULTS: DA modifies alpha-syn with the addition of dopamine-quinone (DAQ) into lysine sites of alpha-syn in vitro and the addition of DAQ and DOPAL (3,4-dihydroxyphenylacetaldehyde) in plasma samples.	quinone	61-68	synuclein alpha	Homo sapiens	96-105	
30112966-6	2018	We moreover observed that 6-OHDA-derived electrophilic quinone induced oxidative stress as indicated by a decrease in glutathione levels, and that this was suppressed by pretreatment with antioxidant NAC.	quinone	55-62	synuclein alpha	Homo sapiens	200-203