PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18778717-0	2008	The effects of 1,4-benzoquinone on c-Myb and topoisomerase II in K-562 cells.	quinone	15-31	MYB proto-oncogene, transcription factor	Homo sapiens	35-40	
18778717-3	2008	BQ has been shown to increase the activity of c-Myb, which is an important transcription factor involved in hematopoiesis, cell proliferation, and cell differentiation.	quinone	0-2	MYB proto-oncogene, transcription factor	Homo sapiens	46-51	
18778717-7	2008	We hypothesized that BQ can increase c-Myb activity, which in turn increases Topo IIalpha promoter activity resulting in increased DNA strand breaks.	quinone	21-23	MYB proto-oncogene, transcription factor	Homo sapiens	37-42	
18778717-10	2008	However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway.	quinone	9-11	MYB proto-oncogene, transcription factor	Homo sapiens	255-260	
18778717-10	2008	However, BQ (37microM for 24h) exposure caused a significant increase in Topo IIalpha promoter activity, which could be blocked by the overexpression of the DBD polypeptide, suggesting that BQ exposure increases Topo IIalpha promoter activity through the c-Myb signaling pathway.	quinone	190-192	MYB proto-oncogene, transcription factor	Homo sapiens	255-260