PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23047025-4 2012 We hypothesize that the cytotoxicity of CGQ in dicoumarol-treated hepatocytes was the result of inhibition of the NQO1 detoxification pathway, thus allowing more quinone to be metabolized towards the one-electron pathway to form reactive semiquinones and/or reactive oxygen species. quinone 162-169 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 114-118 25151970-5 2014 The effect of NQO1 on quinone induced protein handling changes and toxicity was examined using N27 cells stably transfected with NQO1 to generate an isogenic NQO1-overexpressing line. quinone 22-29 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 14-18 25151970-6 2014 NQO1 protected against BQ-induced apoptosis but led to a potentiation of AC- and MD-induced apoptosis. quinone 23-25 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 0-4 25151970-7 2014 Modulation of quinone-induced apoptosis in N27 and NQO1-overexpressing cells correlated only with changes in the ER stress response and not with changes in other protein handling systems. quinone 14-21 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 51-55 25151970-8 2014 These data suggested that NQO1 modulated the ER stress response to potentiate toxicity of AC and MD, but protected against BQ toxicity. quinone 123-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 26-30 23912160-5 2013 The amphipathic quinone coenzyme Q1 (CoQ1; 50 muM) mitigated the impact of rotenone on the adenine nucleotide balance, wherein mitigation was blocked by NAD(P)H-quinone oxidoreductase 1 or mitochondrial complex III inhibitors. quinone 16-23 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 153-185 18455424-5 2008 In the present study, we show that bromocriptine upregulates the expression and activity of NQO1, attenuates the increase in the protein-bound quinone in H(2)O(2)-treated PC12 cells, and protects PC12 cells against oxidative damage. quinone 143-150 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 92-96 20382756-1 2010 We have previously identified that the predominant metabolic pathway for tanshinone IIa (TSA) in rat is the NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated quinone reduction and subsequent glucuronidation. quinone 116-123 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 142-146 15994278-1 2005 NAD(P)H:quinone oxidoreductase 1 (NQO1) plays a dominant role in the reduction of the quinone compound 2,3,5,6-tetramethyl-1,4-benzoquinone (duroquinone, DQ) to durohydroquinone (DQH2) on passage through the rat lung. quinone 8-15 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-38 17305492-0 2007 Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. quinone 81-88 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 67-71 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. quinone 58-65 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 82-86 17305492-8 2007 Dicoumarol, a specific inhibitor of the NAD(P)H dependent quinone oxidoreductase (NQO1), significantly inhibited the metabolic elimination of TS in a noncompetitive way, suggesting that NQO1 was responsible for the quinone reduction of TS to form the catechol intermediate. quinone 58-65 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 186-190 16045903-6 2005 With these substances, therefore, DT-diaphorase both activates and detoxifies the quinone, depending on the target organ. quinone 82-89 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 34-47 12815004-1 2003 Phase II detoxifying enzymes like NAD(P)H (quinone acceptor)oxidoreductase1 (NQO1), glutathione S-transferases (GST), and UDP-glucuronyltransferases (UGT) may play an important role in preventing carcinogen-induced cancers. quinone 43-50 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 77-81 14726156-5 2004 The presence of bovine serum albumin (BSA) in the incubation mixture protects DT-diaphorase against the inactivation by tetrachloro-p-benzoquinone, probably by interacting with the quinone. quinone 139-146 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 78-91 1472082-3 1992 NAD(P)H: (quinone acceptor) oxidoreductase (DT-diaphorase) was the major quinone reductase in the tumour accounting for approximately 70% of all the activity measured in microsomes and cytosols (microsomal activity, 28.4 +/- 4.6 nmol/min/mg; cytosolic activity, 94.3 +/- 11.9 nmol/min/mg). quinone 10-17 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 44-57 12768337-9 2003 Both cytosolic and membrane-bound dicumarol-sensitive NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase, EC 1.6.99.2) activities were decreased by diets supplemented with CoQ(10). quinone 63-70 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 97-110 7746280-1 1995 NAD(P):quinone acceptor oxidoreductase (quinone reductase) (DT-diaphorase, EC 1.6.99.2) is involved in the process of reductive activation of cytotoxic antitumor quinones and nitrobenzenes. quinone 7-14 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 60-73 7733672-1 1995 Following the two-electron reduction of 2-methyl-1,4-naphthoquinone by rat liver DT-diaphorase (also called NAD(P)H: (quinone acceptor) oxidoreductase, EC 1.6.99.2), the hydroquinone product is slowly autoxidized to the quinone in buffered solutions at pH 7.0. quinone 60-67 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 81-94 7733672-1 1995 Following the two-electron reduction of 2-methyl-1,4-naphthoquinone by rat liver DT-diaphorase (also called NAD(P)H: (quinone acceptor) oxidoreductase, EC 1.6.99.2), the hydroquinone product is slowly autoxidized to the quinone in buffered solutions at pH 7.0. quinone 118-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 81-94 737248-1 1978 The development of cytosolic DT-diaphorase--NAD(P)H dehydrogenase, quinone, EC 1.6.99.2--and its induction by benzo(a)pyrene has been studied in rat liver. quinone 67-74 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 29-42 1311584-0 1992 NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals. quinone 9-16 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 43-56 1901207-0 1991 The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) DT diaphorase (NAD(P)H dehydrogenase (quinone), EC 1.6.99.2) isolated from Walker 256 rat carcinoma cells can convert CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) to a cytotoxic DNA interstrand cross-linking agent. quinone 208-215 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 170-206 1406605-0 1992 Suggested mechanism for the modulation of the activity of NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by menadione: interpretation of the effect of menadione on 5"-[p-(Fluorosulfonyl)benzoyl]adenosine labeling of rat liver NAD(P)H:quinone acceptor oxidoreductase. quinone 66-73 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 99-112 1406605-0 1992 Suggested mechanism for the modulation of the activity of NAD(P)H:quinone acceptor oxidoreductase (DT-diaphorase) by menadione: interpretation of the effect of menadione on 5"-[p-(Fluorosulfonyl)benzoyl]adenosine labeling of rat liver NAD(P)H:quinone acceptor oxidoreductase. quinone 243-250 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 99-112 1906377-1 1991 Non-transformed skin fibroblasts derived from five members of a cancer-prone family and three unrelated healthy volunteers were assayed for their levels of activity of the quinone reductase DT-diaphorase and for their sensitivity to the antitumor quinone mitomycin C (MMC). quinone 172-179 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 190-203 1908956-3 1991 The existence of a relatively high superoxide dismutase activity in peripheral nervous tissue, when compared with brain or liver, in combination with the DT-diaphorase activity detected in the sciatic nerve might represent an effective defense mechanism against quinone toxicity, as is also discussed. quinone 262-269 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 154-167 2118386-8 1990 The electron acceptor specificity of this enzyme was very similar to that of NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2, DT-diaphorase) from rat liver. quinone 87-94 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 134-147 6191666-2 1983 Chemiluminescence was augmented when the two-electron reduction of the quinone catalyzed by NAD(P)H:quinone reductase was inhibited by dicoumarol, thus underlining the protective function of this enzyme also known as DT-diaphorase. quinone 71-78 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 217-230