PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20345183-8	2010	TrxR also catalyzes quinone redox cycling, a process that generates reactive oxygen species.	quinone	20-27	peroxiredoxin 5	Homo sapiens	0-4	
27070533-10	2016	Also unforeseen was the inhibitors" mechanism of action against TrxR, which was found to be brokered through a suicide-mechanism utilizing quinone methide as the inactivating element.	quinone	139-146	peroxiredoxin 5	Homo sapiens	64-68	
22694104-8	2012	On the basis of kinetic and spectroscopic data, we propose a chemical mechanism for the inactivation of the enzyme that starts with a reduction of the quinone ring of MMC by the selenolthiol active site of TrxR and a subsequent alkylation of the active site by the activated drug.	quinone	151-158	peroxiredoxin 5	Homo sapiens	206-210	
20951799-8	2010	Using mass spectrometry, we have demonstrated the formation of EGCG-Trx1 (Cys(32)) and EGCG-TrxR (Cys/Sec) conjugates, confirming that EGCG quinone specifically conjugates with active-site Cys(32) in Trx or C-terminal Cys/Selenocysteine (Sec) couple in TrxR under conditions where Trx/TrxR are reduced.	quinone	140-147	peroxiredoxin 5	Homo sapiens	253-257	
20951799-8	2010	Using mass spectrometry, we have demonstrated the formation of EGCG-Trx1 (Cys(32)) and EGCG-TrxR (Cys/Sec) conjugates, confirming that EGCG quinone specifically conjugates with active-site Cys(32) in Trx or C-terminal Cys/Selenocysteine (Sec) couple in TrxR under conditions where Trx/TrxR are reduced.	quinone	140-147	peroxiredoxin 5	Homo sapiens	253-257	
15867391-5	2005	Indeed, COMPARE analysis within the National Cancer Institute database revealed a number of chemically related quinone derivatives that could potentially react with sulfur nucleophiles in a similar manner and suggested that thioredoxin/thioredoxin reductase signal transduction could be a putative target.	quinone	111-118	peroxiredoxin 5	Homo sapiens	236-257