PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33190980-4	2021	We first confirmed that PCB quinone induces cancerous HeLa and MDA-MB-231 cells necroptosis via the phosphorylation of mixed lineage kinase domain-like MLKL (p-MLKL).	quinone	28-35	mixed lineage kinase domain like pseudokinase	Homo sapiens	152-156	
33190980-4	2021	We first confirmed that PCB quinone induces cancerous HeLa and MDA-MB-231 cells necroptosis via the phosphorylation of mixed lineage kinase domain-like MLKL (p-MLKL).	quinone	28-35	mixed lineage kinase domain like pseudokinase	Homo sapiens	160-164	
33190980-5	2021	Then, we found that PCB quinone-stimulated p-MLKL enhances exosome biogenesis and secretion.	quinone	24-31	mixed lineage kinase domain like pseudokinase	Homo sapiens	45-49	
33190980-6	2021	Exosome interacts with p-MLKL and releases p-MLKL to the outside of the cell, and ultimately alleviating PCB quinone-induced necroptosis.	quinone	109-116	mixed lineage kinase domain like pseudokinase	Homo sapiens	25-29	
33190980-7	2021	The inhibition of exosome secretion by GW4869 significantly elevated necroptotic level, indicating the establishment of a short negative feedback loop of MLKL-exosome secretion upon PCB quinone challenge.	quinone	186-193	mixed lineage kinase domain like pseudokinase	Homo sapiens	154-158