PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27438141-7	2017	We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm.	quinone	35-42	kelch like ECH associated protein 1	Homo sapiens	108-143	
17046835-6	2006	Quinone-induced oxidative stress and the chemopreventive agent sulforaphane inhibit Keap1-dependent ubiquitination of PGAM5.	quinone	0-7	kelch like ECH associated protein 1	Homo sapiens	84-89	
15983046-5	2005	Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione.	quinone	66-73	kelch like ECH associated protein 1	Homo sapiens	18-23	
15983046-5	2005	Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione.	quinone	66-73	kelch like ECH associated protein 1	Homo sapiens	138-143	
15983046-5	2005	Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione.	quinone	66-73	kelch like ECH associated protein 1	Homo sapiens	138-143	
15572695-5	2004	Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate.	quinone	83-90	kelch like ECH associated protein 1	Homo sapiens	0-5	
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	quinone	167-174	kelch like ECH associated protein 1	Homo sapiens	9-14	
15572695-6	2004	A mutant Keap1 protein containing a single cysteine-to-serine substitution at residue 151 within the BTB domain of Keap1 is markedly resistant to inhibition by either quinone-induced oxidative stress or sulforaphane.	quinone	167-174	kelch like ECH associated protein 1	Homo sapiens	115-120	
28286015-8	2017	LC-MS/MS analysis indicated that rutin quinone targets cysteine 151 of Keap1.	quinone	39-46	kelch like ECH associated protein 1	Homo sapiens	71-76	
27438141-7	2017	We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm.	quinone	35-42	kelch like ECH associated protein 1	Homo sapiens	145-150	
23035985-0	2012	Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide.	quinone	0-7	kelch like ECH associated protein 1	Homo sapiens	30-35	
20846517-5	2011	Consequently, a two-step mechanism was proposed which involves oxidation of the diphenols to their corresponding quinone derivatives, followed by modification of specific cysteine residues of the sensor protein Keap1.	quinone	113-120	kelch like ECH associated protein 1	Homo sapiens	211-216	
22224553-6	2012	Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the gene transcription of antioxidant enzymes.	quinone	44-51	kelch like ECH associated protein 1	Homo sapiens	105-110	
20558128-10	2010	We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm.	quinone	37-44	kelch like ECH associated protein 1	Homo sapiens	146-181	
20558128-10	2010	We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm.	quinone	37-44	kelch like ECH associated protein 1	Homo sapiens	183-188