PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22192820-0 2012 Ah receptor- and Nrf2-gene battery members: modulators of quinone-mediated oxidative and endoplasmic reticulum stress. quinone 58-65 NFE2 like bZIP transcription factor 2 Homo sapiens 17-21 24361488-3 2014 There are no reports describing the ability of PCB quinone on Nrf2/ARE activation. quinone 51-58 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 23035985-0 2012 Quinone-induced activation of Keap1/Nrf2 signaling by aspirin prodrugs masquerading as nitric oxide. quinone 0-7 NFE2 like bZIP transcription factor 2 Homo sapiens 36-40 22192820-8 2012 In conclusion, tight coupling of Ah receptor- and Nrf2-regulated enzymes may prevent quinone-mediated oxidative and ER stress. quinone 85-92 NFE2 like bZIP transcription factor 2 Homo sapiens 50-54 21059386-0 2011 Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity. quinone 63-75 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 22224553-6 2012 Compounds that possess an orthodihydroxy or quinone structure can interact with cellular proteins in the Keap1/Nrf2/ARE pathway to activate the gene transcription of antioxidant enzymes. quinone 44-51 NFE2 like bZIP transcription factor 2 Homo sapiens 111-115 21059386-6 2011 Moreover, transient overexpression of Nrf2 conferred protection against HQ- and BQ-induced cell death, whereas knockdown of Nrf2 by small interfering RNA resulted in increased apoptosis. quinone 80-82 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 21059386-7 2011 We also found that the increased susceptibility of Nrf2-knockdown cells to HQ and BQ was associated with reduced glutathione levels and loss of inducibility of ARE-driven genes, suggesting that deficiency of Nrf2 impairs cellular redox capacity to counteract oxidative damage. quinone 82-84 NFE2 like bZIP transcription factor 2 Homo sapiens 51-55 21059386-7 2011 We also found that the increased susceptibility of Nrf2-knockdown cells to HQ and BQ was associated with reduced glutathione levels and loss of inducibility of ARE-driven genes, suggesting that deficiency of Nrf2 impairs cellular redox capacity to counteract oxidative damage. quinone 82-84 NFE2 like bZIP transcription factor 2 Homo sapiens 208-212 21059386-8 2011 Altogether, these results suggest that Nrf2-ARE pathway is essential for protection against HQ- and BQ-induced toxicity. quinone 100-102 NFE2 like bZIP transcription factor 2 Homo sapiens 39-43 21059386-5 2011 Increased expression of well-known Nrf2-dependent proteins including NQO1, GCLM, GSS and HMOX was also observed in the HQ/BQ-treated cells. quinone 122-124 NFE2 like bZIP transcription factor 2 Homo sapiens 35-39 15572695-5 2004 Keap1-dependent ubiquitination of Nrf2 is inhibited following exposure of cells to quinone-induced oxidative stress and sulforaphane, a cancer-preventive isothiocyanate. quinone 83-90 NFE2 like bZIP transcription factor 2 Homo sapiens 34-38 19236154-3 2009 Data generated by various groups indicate that Nrf2 induces the expression of a group of cytoprotective, antixenobiotic and antioxidant enzymes that include heme oxygenase-1, NAD(P)H:quinone oxidoreductase and enzymes of glutathione (GSH) metabolism such as gamma-glutamyl cysteine ligase, GSH transferases and so on. quinone 183-190 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 15983046-5 2005 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone 66-73 NFE2 like bZIP transcription factor 2 Homo sapiens 172-176 15525690-2 2005 The present study is aimed to determine whether increased protein stability is a mechanism by which quinone compounds, like tert-butylhydroquinone (tBHQ), may enhance Nrf2-mediated transcriptional activation and subsequent antioxidant protection. quinone 100-107 NFE2 like bZIP transcription factor 2 Homo sapiens 167-171 20558128-10 2010 We hypothesize that an electrophilic quinone formed as a consequence of oxidation of piceatannol bearing the catechol moiety may bind directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 37-44 NFE2 like bZIP transcription factor 2 Homo sapiens 229-233 32868290-6 2020 Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity. quinone 75-82 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 34348209-2 2021 The benzoquinone structural motive is associated with mutagenicity and carcinogenicity, and also with induction of the oxidative stress response through the Nrf2 pathway. quinone 4-16 NFE2 like bZIP transcription factor 2 Homo sapiens 157-161 32868290-6 2020 Mechanistically, we show that products of NRF2 target genes metabolize the quinone-containing geldanamycin compounds into more potent HSP90 inhibitors, which enhances their cytotoxicity while simultaneously restricting the synthetic lethal effect to cells with aberrant NRF2 activity. quinone 75-82 NFE2 like bZIP transcription factor 2 Homo sapiens 270-274 28286015-12 2017 CONCLUSION AND SIGNIFICANCE: Rutin functions as an antioxidant and is oxidized into a quinone that upregulates the Nrf2-mediated endogenous antioxidant response. quinone 86-93 NFE2 like bZIP transcription factor 2 Homo sapiens 115-119 26779013-7 2015 In addition, 5-Aza-mediated upregulation of Nrf2 expression was concomitant with increased nuclear translocation of Nrf2 and higher expression of Nrf2 downstream target gene NAD(P)H: quinone oxidoreductas (NQO1). quinone 183-190 NFE2 like bZIP transcription factor 2 Homo sapiens 44-48 27438141-7 2017 We speculate that an electrophilic quinone formed as a consequence of oxidation of 4-OHE2 binds directly to Kelch-like ECH-associated protein 1 (Keap1), an inhibitory protein that sequesters Nrf2 in the cytoplasm. quinone 35-42 NFE2 like bZIP transcription factor 2 Homo sapiens 191-195 25437431-0 2014 Regulation of PKM2 and Nrf2-ARE pathway during benzoquinone induced oxidative stress in yolk sac hematopoietic stem cells. quinone 47-59 NFE2 like bZIP transcription factor 2 Homo sapiens 23-27 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 166-178 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 25437431-3 2014 In the present report, we investigated the effect of PKM2 and Nrf2-ARE pathway on the cellular antioxidant response to oxidative stress induced by benzene metabolite benzoquinone (BQ) in YS-HSC isolated from embryonic yolk sac and enriched by magnetic-activated cell sorting (MACS). quinone 180-182 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66