PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11316576-8 2001 We conclude that the tyrosinase-derived reactive quinone intermediate(s) of PA, which binds nucleophilic residues of proteins including sulfhydryl group and conjugates of which are recognized as haptens, was partially involved in alteration of the cellular immune functions including oxygen radical-generating leukocytes migration to inflamed regions. quinone 49-56 tyrosinase Mus musculus 21-31 403000-12 1977 These studies provide evidence that GHB exerts cytotoxicity specifically for cells that by their content of tyrosinase convert the phenol to the quinone. quinone 145-152 tyrosinase Mus musculus 108-118 8435097-9 1993 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone mediated mechanism of phenolic amine cytotoxicity may be uniquely important and the cellular antioxidant glutathione essential in the detoxification of these quinone-generated intermediates. quinone 66-73 tyrosinase Mus musculus 50-60 8435097-9 1993 In pigmented melanoma cells containing the enzyme tyrosinase, the quinone mediated mechanism of phenolic amine cytotoxicity may be uniquely important and the cellular antioxidant glutathione essential in the detoxification of these quinone-generated intermediates. quinone 232-239 tyrosinase Mus musculus 50-60 403000-1 1977 A stable phenol, gamma-L-glutaminyl-4-hydroxybenzene (GHB), is oxidized by tyrosinase in the gill tissues of the mushroom Agaricus bisporus to a quinone and a second oxidation product which together suppress mitochondrial energy production and the synthesis of proteins and nucleic acids in the zygote, thus establishing dormancy in the spores. quinone 145-152 tyrosinase Mus musculus 75-85 19548356-5 2008 The intrinsic capacity of catechins to form quinone type metabolites upon their oxidation was demonstrated using incubations of epigallocatechin (EGC) and EGCG with tyrosinase and the GSH-trapping method. quinone 44-51 tyrosinase Mus musculus 165-175