PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31754153-3 2019 In this study, we report that febuxostat, an inhibitor of XOR, suppressed NLRP3 inflammasome-mediated IL-1beta secretion and cell death by two mechanisms: in a mitochondrial ROS (mitoROS)-dependent and mitoROS-independent manner. febuxostat 30-40 xanthine dehydrogenase Homo sapiens 58-61 31556223-1 2019 Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol and febuxostat, inhibit the catalysis of serum uric acid (SUA) synthesis. febuxostat 66-76 xanthine dehydrogenase Homo sapiens 0-23