PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31677062-3 2020 We postulated that febuxostat, a novel xanthine oxidase inhibitor, could suppress the ER stress through upregulation of SIRT1 (silent mating type information regulation 2 homolog 1)-AMPK (AMP activated protein kinase)-HO-1 (heme oxygenase-1)/thioredoxin expression. febuxostat 19-29 heme oxygenase 1 Mus musculus 224-241 31677062-8 2020 Inhibitory effect of febuxostat was mediated through upregulation of SIRT1-AMPK followed by induction of HO-1 and thioredoxin. febuxostat 21-31 heme oxygenase 1 Mus musculus 105-125