PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23936743-6	2013	Medicinal compounds like Ortho-7, Dibucaine and HI-6 are predicted as good targets for modeled AChE and BChE proteins based on docking studies.	asoxime chloride	48-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99	
23917882-0	2013	Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics.	asoxime chloride	35-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20	
23111374-6	2013	Regarding the reactivation of VX-inhibited hAChE, all compounds show a better reactivation potency than those of 2-PAM, nevertheless they are less efficient than obidoxime and HI-6.	asoxime chloride	176-180	acetylcholinesterase (Cartwright blood group)	Homo sapiens	43-48	
23376121-0	2013	Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity.	asoxime chloride	120-124	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-88	
23376121-5	2013	The interaction between HI-6 and tabun-adducts of AChE were subsequently investigated using a combination of time resolved fluorescence spectroscopy and X-ray crystallography.	asoxime chloride	24-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54	
23376121-6	2013	Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun.	asoxime chloride	23-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70	
23376121-6	2013	Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun.	asoxime chloride	23-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-77	
23376121-6	2013	Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun.	asoxime chloride	161-165	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70	
23376121-6	2013	Our findings show that HI-6 binds to tabun inhibited Homo sapiens AChE (hAChE) with an IC50 value of 300muM and suggest that the reactive nucleophilic moiety of HI-6 is excluded from the phosphorus atom of tabun.	asoxime chloride	161-165	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-77	
22982773-2	2013	Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate.	asoxime chloride	86-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52	
22982773-2	2013	Rate constants for reactivation of OP-inhibited AChE by even the best oximes, such as HI-6 and obidoxime, can vary >100-fold between OP-AChE conjugates that are easily reactivated and those that are difficult to reactivate.	asoxime chloride	86-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143	
21673941-1	2011	We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos).	asoxime chloride	151-155	acetylcholinesterase (Cartwright blood group)	Homo sapiens	177-197	
22447833-1	2012	Oxime HI-6 is an efficient reactivator of the acetylcholinesterase inhibited by organophosphorous nerve agents.	asoxime chloride	6-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-66	
23030612-7	2012	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam are used for the treatment of organophosphate poisoning in humans.	asoxime chloride	169-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72	
21803135-6	2011	30 muM HI 6 resulted in an almost complete recovery of sarin blocked muscle force and in an increase of completely inhibited muscle AChE activity to approx.	asoxime chloride	7-11	acetylcholinesterase (Cartwright blood group)	Homo sapiens	132-136	
21730071-6	2011	With the most efficient human AChE mutant Y337A/F338A, we show enhanced reactivation rates for several OP-hAChE conjugates compared with wild-type hAChE when reactivated with HI-6 (1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium)).	asoxime chloride	175-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34	
20027669-5	2011	Commercial AChE reactivators (e.g. pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) were originally developed for other members of the organophosphate family, such as nerve agents (e.g. sarin, soman, tabun, VX).	asoxime chloride	48-52	acetylcholinesterase (Cartwright blood group)	Homo sapiens	11-15	
20027669-6	2011	Pralidoxime, HI-6, and methoxime were found to be weak reactivators of OPP-inhibited AChE.	asoxime chloride	13-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89	
22360473-7	2012	The current treatment for OPNA poisoning combines an antimuscarinic drug (e.g., atropine), an anticonvulsant drug (e.g., diazepam), and an AChE reactivator of the pyridinium aldoxime family (pralidoxime, trimedoxime, obidoxime, HI-6, HLo-7).	asoxime chloride	228-232	acetylcholinesterase (Cartwright blood group)	Homo sapiens	139-143	
21451868-2	2011	Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLo-7.	asoxime chloride	189-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96	
21673941-1	2011	We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different organophosphate pesticides and inhibitors (paraoxon, dichlorvos, DFP, leptophos-oxon and methamidophos).	asoxime chloride	151-155	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-203	
19663821-5	2009	Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue.	asoxime chloride	5-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	39-43	
20888357-8	2010	Due to the high reactivity of MMB-4 a rapid reactivation of inhibited AChE can be anticipated at adequate oxime concentrations which are substantially higher compared to HI-6.	asoxime chloride	170-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74	
20655881-6	2010	A homology model for wild-type Bo AChE was built using the recently published crystal structure of human AChE and used to generate models of 2-PAM and HI-6 bound to the active-sites of GF- and VR-inhibited Bo AChEs before nucleophilic attack.	asoxime chloride	151-155	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109	
20417629-1	2010	Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)).	asoxime chloride	100-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-42	
20417629-1	2010	Catalytic activity of acetylcholinesterase (AChE; EC 3.1.1.7) was studied in the presence of oximes HI-6, K114, K127 and K203, and inhibition constants were determined for the reversible enzyme-inhibitor complex (K(I)).	asoxime chloride	100-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-48	
19663821-5	2009	Both HI-6 and irinotecan inhibited ChE/AChE activity but showed different levels of ChE inhibition in plasma and AChE inhibition in the liver and brain tissue.	asoxime chloride	5-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117	
20020898-1	2008	ABSTRACT This study describes the evaluation of the in vitro ability of two acetylcholinesterase (EC 3.1.1.7) reactivators, HI-6 and HLo-7, very promising at present, to reactivate human brain cholinesterases inhibited by the nerve agent cyclosarin.	asoxime chloride	124-128	acetylcholinesterase (Cartwright blood group)	Homo sapiens	76-96	
19651196-9	2009	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the recommended pyridinium oximes (pralidoxime, trimedoxime, obidoxime and HI-6) and diazepam are used for the treatment of OP poisoning in humans.	asoxime chloride	175-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72	
19429253-7	2009	Pentylsarin-inhibited AChE could be reactivated by oximes, HI 6 being more potent than obidoxime.	asoxime chloride	59-63	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26	
19356117-0	2009	Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series.	asoxime chloride	33-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-89	
19761810-3	2009	To investigate HI-6, K027 and HLo-7, residues lining the active-site gorge of hAChE were substituted and the effects on kinetic parameters for reactivation were determined.	asoxime chloride	15-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-83	
19519385-8	2009	Presently, a combination of an antimuscarinic agent, e.g. atropine, AChE reactivator such as one of the standard pyridinium oximes (pralidoxime, trimedoxime, obidoxime, HI-6) and diazepam has been used for the treatment of organophosphate poisoning in humans.	asoxime chloride	169-173	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72	
18804659-8	2008	The most significant identification was based on methamidophos inhibited AChE reactivation by HI-6 or pralidoxime and paraoxon-ethyl inhibited AChE by obidoxime; moreover, identification of trichlorfon and paraoxon-methyl was possible, too.	asoxime chloride	94-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	73-77	
17370251-0	2007	Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro.	asoxime chloride	86-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	48-52	
17370251-5	2007	In order to investigate the feasibility of combining obidoxime and HI 6, human AChE inhibited by sarin, cyclosarin, VX, tabun and paraoxon was reactivated by these oximes either alone or in combination.	asoxime chloride	67-71	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83	
17900152-8	2007	The most significant enhancement was observed in the reactivation of human AChE inhibited by nerve agents containing bulky side chains GF, GD, and VR, by H-series oximes HLo-7, HI-6, and ICD-585.	asoxime chloride	177-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79	
17913691-8	2007	After administration of HI-6, RBC-AChE activity increased rapidly.	asoxime chloride	24-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38	
18254274-0	2007	Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX).	asoxime chloride	65-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-136	
17713603-5	2007	HI-6 was effective in protection of AChE and increased its activity up to 30%; the residual activity after irinotecan inhibition was 7%.	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	36-40	
18254274-5	2007	In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used.	asoxime chloride	77-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-38	
18254274-5	2007	In this study, five commonly used AChE reactivators (pralidoxime, methoxime, HI-6, obidoxime, trimedoxime) for the reactivation of AChE inhibited by two pesticides (chlorpyrifos and methylchlorpyrifos) were used.	asoxime chloride	77-81	acetylcholinesterase (Cartwright blood group)	Homo sapiens	131-135	
17252938-9	2006	Two AChE reactivators, K027 and K033, achieved comparable reactivation potency as HI-6.	asoxime chloride	82-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8	
17288495-10	2006	The article also discusses the possibility of successful therapy with HI-6 against poisoning in humans relative to doses used in non-human primates and relative to its ability to reactivate inhibited human AChE.	asoxime chloride	70-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	206-210	
18072133-6	2006	However, oxime HI-6 (33%) and obidoxime (23%) seem to be the best AChE reactivators for human relevant doses (10(-4) M and lower).	asoxime chloride	15-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-70	
16740352-5	2006	On the base of species-specific kinetic data this model was used to calculate AChE activities in humans and pigs after percutaneous exposure to 5 x LD50 VX and treatment with HI 6.	asoxime chloride	175-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-82	
16429518-1	2005	The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin.	asoxime chloride	133-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	78-98	
16429518-1	2005	The aim of this work was the comparison of reactivation potency of four oxime acetylcholinesterase (AChE) reactivators (pralidoxime, HI-6, K027 and K033) on three resources of the enzyme (human, pig and rat brain homogenate) inhibited by nerve agent sarin.	asoxime chloride	133-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-104	
16124202-3	2005	AChE reactivators (pralidoxime, obidoxime and HI-6) as causal antidotes are used for the cleavage of the bond between the enzyme and nerve agent.	asoxime chloride	46-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-4	
16119192-3	2005	Therefore, to better evaluate the efficacy of various oximes (pralidoxime, obidoxime, HI-6, K033) to reactivate brain acetylcholinesterase inhibited by sarin by in vitro methods, human, rat and pig brain acetylcholinesterase were used to calculate kinetic parameters for the reactivation.	asoxime chloride	86-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138	
20021089-3	2005	We have confirmed the fact that currently the most promising AChE reactivator, HI-6, is the most effective reactivator of sarin-inhibited AChE.	asoxime chloride	79-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	61-65	
20021089-3	2005	We have confirmed the fact that currently the most promising AChE reactivator, HI-6, is the most effective reactivator of sarin-inhibited AChE.	asoxime chloride	79-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	138-142	
20021089-4	2005	There are only three AChE reactivators-HI-6, TO033 and TO047-able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10(-5) M, which is nontoxic for human use.	asoxime chloride	39-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	21-25	
20021089-4	2005	There are only three AChE reactivators-HI-6, TO033 and TO047-able to satisfactorily reactivate sarin-inhibited AChE at the concentration 10(-5) M, which is nontoxic for human use.	asoxime chloride	39-43	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-115	
9587020-6	1998	Isolated human erythrocyte AChE was inhibited with soman, sarin, cyclosarin, tabun or VX for 30 min and reactivated in the absence of inhibitory activity over 5-60 min by obidoxime, pralidoxime, HI 6 or HLo 7 (10 and 30 microM).	asoxime chloride	195-199	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-31	
11303072-7	2001	The reactivation time of HI-6 on soman-inhibited AChE was 6 +/- 2 min.	asoxime chloride	25-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53	
10801325-2	2000	We have examined the reactivation of a series of resolved enantiomeric methylphosphonate conjugates of acetylcholinesterase by two oximes, 2-pralidoxime (2-PAM) and 1-(2"-hydroxyiminomethyl-1"-pyridinium)-3-(4"-carbamoyl-1-pyridinium) (HI-6).	asoxime chloride	236-240	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123	
8911635-3	1996	In spite of this drawback, oximes are worth further investigating, since recent data derived from soman or tabun lethally intoxicated non-human primates suggest that the oxime HI-6 may exert a pharmacological effect that is not related to reactivation of inhibited AChE, but still leads to survival.	asoxime chloride	176-180	acetylcholinesterase (Cartwright blood group)	Homo sapiens	265-269	
8493783-3	1993	Also, there have been no significant differences in efficacy and speed of reactivation of acetylcholinesterase inhibited by organophosphates when HI-6 is applied in the form of permanent intravenous infusion or repeated intramuscular injections.	asoxime chloride	146-150	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110	
8750900-0	1995	Methantheline improves the reactivation by HI 6 of human erythrocyte acetylcholinesterase inhibited by soman in vitro.	asoxime chloride	43-47	acetylcholinesterase (Cartwright blood group)	Homo sapiens	69-89	
8750900-4	1995	With HI 6 alone, the portion of AChE activity which could be reactivated 25 min after the start of ageing decreased rapidly with the delay of the oxime addition (100% of the original activity at immediate addition), the half-life being approximately 2.5 min.	asoxime chloride	5-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-36	
7857205-1	1994	The purpose of this study was to compare the in vitro reactivation of the various molecular forms of soman-inhibited acetylcholinesterase by oximes such as HI-6, toxogonin and PAM, in striated muscle tissue from three species-rat, monkey and human.	asoxime chloride	156-160	acetylcholinesterase (Cartwright blood group)	Homo sapiens	117-137	
7857205-5	1994	HI-6 (Pre-Post) increased significantly the activity of soman-inhibited acetylcholinesterase in the rat, human and monkey muscle.	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92	
7857205-10	1994	In addition, SAD-128, a non-oxime bispyridinium compound, appeared to enhance significantly the HI-6 induced reactivation of soman-inhibited acetylcholinesterase in human but not rat striated muscle.	asoxime chloride	96-100	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-161	
1412499-5	1992	Based on 95% confidence limits the rank order of potentiation with eel AChE was TMB-4 = Toxogonin > HS-6 = HI-6 > 2-PAM Cl.	asoxime chloride	110-114	acetylcholinesterase (Cartwright blood group)	Homo sapiens	71-75	
2917018-5	1989	HLo-7 is also much more active than HI-6 when used as a reactivator for electric eel AChE inhibited by some N-unsubstituted derivatives of tabun.	asoxime chloride	36-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89	
1733041-2	1992	HI-6, but neither toxogonin nor PAM Cl, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase.	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	100-120	
1733041-2	1992	HI-6, but neither toxogonin nor PAM Cl, antagonized sarin-induced hypothermia and reactivated brain acetylcholinesterase, in particular hypothalamic acetylcholinesterase.	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-169	
1890690-6	1991	The oxime HI-6 reactivated soman phosphonylated enzymes to a considerably greater extent than other oximes, and FBS AChE was notably more responsive to HI-6 than to other oximes.	asoxime chloride	152-156	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120	
33538594-0	2021	Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.	asoxime chloride	142-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	65-85	
2596267-6	1989	The results show that HI-6 can attenuate lesions only if AChE is partially reactivated and muscle fasciculations are permanently eliminated.	asoxime chloride	22-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61	
2742504-5	1989	On the other hand, in human muscle therapeutic treatment restored only 5%, while prophylactic application of HI-6 again resulted in about 50% recovery of control AChE activity.	asoxime chloride	109-113	acetylcholinesterase (Cartwright blood group)	Homo sapiens	162-166	
2742504-7	1989	Immediate reactivation of rapidly aging human AChE must therefore be instituted for successful protective treatment by HI-6.	asoxime chloride	119-123	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50	
3345199-9	1988	All effectors increased the AChE reactivatability by HI 6 when added before aging was started.	asoxime chloride	53-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	28-32	
3827594-1	1986	HI 6 has been shown to be efficacious in soman intoxication of laboratory animals by reactivation of acetylcholinesterase.	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-121	
7426043-0	1980	Reactivation of acetylcholinesterase inhibited by 1,2,2"-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes.	asoxime chloride	112-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	16-36	
2742504-8	1989	Retardation of aging, a direct effect of SAD-128, was roughly estimated to improve reactivation by HI-6 for about 10% of control AChE activity of the human muscle.	asoxime chloride	99-103	acetylcholinesterase (Cartwright blood group)	Homo sapiens	129-133	
33831382-7	2021	After 30 min of incubation of AChE with soman, 5 min of aging and 20 min of reactivation by asoxime (HI-6 dichloride), AChE activity was 8.1% in control medium, 30.7% and 41.9% after addition of 1 and 10 mmol/l memantine, and 16.1% after addition of 1 mmol/l Mrz 2/373.	asoxime chloride	101-116	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-123	
33538594-7	2021	With reports indicating that the efficacy of reactivators can vary based on the nerve agent inhibiting hAChE, human recombinatorially expressed hAChE was utilized to define these variations for HI-6 among various G-agents.	asoxime chloride	194-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	144-149	
33538594-8	2021	To identify the structural underpinnings of this phenomenon, the structures of tabun, sarin, and soman-inhibited hAChE in complex with HI-6 were determined.	asoxime chloride	135-139	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-118	
32267631-1	2020	Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.	asoxime chloride	53-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-148	
32267631-1	2020	Oximes like pralidoxime (2-PAM), obidoxime (Obi) and HI-6 are the only currently available therapeutics to reactivate inhibited acetylcholinesterase (AChE) in case of intoxications with organophosphorus (OP) compounds.	asoxime chloride	53-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154	
28993240-5	2018	It turned out that only HI-6 was able to slow down the ongoing inhibition of human AChE by soman without preventing final complete inhibition of the enzyme.	asoxime chloride	24-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87	
30763608-9	2019	Both substances restored AChE activity in a dose-dependent way, with HI-6 being more potent (HI-6 EC50 = 3.8 muM vs obidoxime EC50 = 197.8 muM).	asoxime chloride	69-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-29	
32175496-3	2020	HI-6 and 2-PAM are cationic oximes proved to be effective for the reactivation of AChE inhibited by the nerve agents VX and sarin (GB).	asoxime chloride	0-4	acetylcholinesterase (Cartwright blood group)	Homo sapiens	82-86	
32175496-9	2020	In contrast, HI-6 and 2-PAM showed higher affinities with more negative binding energy values and larger contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of oximes with AChE-GB and AChE-VX conjugates.	asoxime chloride	13-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	246-250	
30858091-12	2019	However, the oxime HI-6 as potent reactivator of cyclosarin-inhibited AChE was not able to prevent the FPDc prolongation in this model.	asoxime chloride	19-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74	
30462502-0	2018	Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6.	asoxime chloride	116-120	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78	
30462502-4	2018	Beyond identifying hAChE structural features that lend themselves to stereospecific inhibition, structures of the reactivator HI-6 bound to hAChE inhibited by VX enantiomers of varying toxicity, or in its uninhibited state, were obtained.	asoxime chloride	126-130	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-145	
30312685-8	2018	A combination of 3 l and the bispyridinium oxime HI-6 was tested to reactivate OP-inhibited AChE: The superior reactivator of the respective OP-AChE combination dominated the reactivation process and a synergistic effect could not be observed.	asoxime chloride	49-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	92-96	
29019446-3	2018	In order to try to find out the reason for this, a computational study involving molecular docking, molecular dynamics, and binding energies calculations, was performed on the binding modes of HI-6 and HS-6 on human AChE (HssAChE) inhibited by those nerve agents.	asoxime chloride	193-197	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-220	
28446076-0	2018	Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach.	asoxime chloride	41-44	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72	
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	asoxime chloride	170-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-126	
28446076-2	2018	Some oximes such HI6 as 2-PAM are nucleophiles that are capable to reactivate inhibited human AChE under some conditions.	asoxime chloride	17-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	94-98	
28446076-7	2018	In contrast, HI 6 and 2-PAM showed high binding energy values with great contribution of the amino acid Asp74, demonstrating the importance of the quaternary nitrogen to the affinity and interaction of the oximes/AChE tabun-inhibited complexes.	asoxime chloride	13-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	213-217	
29773682-2	2018	To investigate oximate water structure changes in this reaction, reactivation of paraoxon-inhibited human acetylcholinesterase (AChE) was performed by the oxime asoxime (HI-6) at different pH in the presence and absence of lyotropic salts: a neutral salt (NaCl), a strong chaotropic salt (LiSCN) and strong kosmotropic salts (ammonium sulphate and phosphate HPO42-).	asoxime chloride	170-174	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132	
29735900-2	2018	For the recovery of inhibited AChE, antidotes from the group of pyridinium or bispyridinium aldoxime reactivators (pralidoxime, obidoxime, HI-6) are used in combination with anticholinergics and anticonvulsives.	asoxime chloride	139-143	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34	
27153754-0	2016	Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.	asoxime chloride	79-83	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64	
27358236-4	2017	We here semiquantitatively investigate the ability of obidoxime and HI-6 to decrease the inhibitory activity of VX with human AChE and BChE from whole blood, erythrocyte membranes, erythrocytes, plasma, clinically available fresh frozen plasma and packed red blood cells.	asoxime chloride	68-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	126-130	
27191504-8	2016	Ternary structures of paraoxon-inhibited human acetylcholinesterase in complex with the oximes HI6 and 2-PAM reveals relatively poor positioning for reactivation.	asoxime chloride	95-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-67	
27179675-7	2016	Based on the full information provided by this method, the efficacy of reactivators, such as HI-6, obidoxime and pralidoxime, in the typical treatment of NAs poisoned AChE in in vitro was further evaluated.	asoxime chloride	93-97	acetylcholinesterase (Cartwright blood group)	Homo sapiens	167-171	
27153754-0	2016	Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics.	asoxime chloride	98-102	acetylcholinesterase (Cartwright blood group)	Homo sapiens	44-64	
27153754-5	2016	The oxime-induced reactivation of inhibited human AChE in the presence of nerve agents is markedly impaired and the combination of obidoxime and HI-6 had no additive effect but could broaden the spectrum.	asoxime chloride	145-149	acetylcholinesterase (Cartwright blood group)	Homo sapiens	50-54	
26468911-2	2015	We present oxime (HI-6) unbinding from the active site gorge of AChE, known to be strongly influenced by intermolecular cation-pi, hydrogen bridge (HB) and water bridge (WB) interactions and by molecular simulations with effective polarization in polarizable mean-field model of TIP3P water.	asoxime chloride	18-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68	
25240274-5	2014	Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity.	asoxime chloride	92-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24	
25240274-5	2014	Incubation of human AChE with millimolar DF and MF and subsequent addition of obidoxime and HI-6 resulted in a concentration-dependent decrease of AChE activity.	asoxime chloride	92-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	147-151