PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34969831-4	2022	To this end, a theophylline structure was connected to a pyrrolidine structure through a methylene chain of different lengths (3 to 7 carbon atoms) to give compounds 7-11 All caffeine derivatives inhibited the AChE, of which compound 11 showed the strongest effect.	pyrrolidine	57-68	acetylcholinesterase (Cartwright blood group)	Homo sapiens	210-214	
20951037-1	2010	Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors.	pyrrolidine	10-20	acetylcholinesterase (Cartwright blood group)	Homo sapiens	86-90	
2003276-4	1991	A structural feature common to these compounds is the N-methyl determinant of the pyrrolidine ring which may be important in binding to the AChE.	pyrrolidine	82-93	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-144	
34643082-1	2021	To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated.	pyrrolidine	219-230	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99	
34643082-1	2021	To obtain a multipotent framework that can target simultaneously COX-2, 5-LOX, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) to treat neuroinflammation, a series of derivatives containing pyrimidine and pyrrolidine cores were rationally synthesized and evaluated.	pyrrolidine	219-230	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105	
33583373-5	2021	Interestingly, synthetic xanthone derivatives with complex substituents such as alkyl, pyrrolidine, piperidine and morpholine have shown greater acetylcholinesterase inhibition activities.	pyrrolidine	87-98	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-165	
30312685-3	2018	Recently, we reported of a pyrrolidine-bearing ADOC analogue (3 l) with a remarkable ability to reactivate OP-inhibited AChE.	pyrrolidine	27-38	acetylcholinesterase (Cartwright blood group)	Homo sapiens	120-124