PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29631096-7 2018 The mechanism by which decreased CES1 activity exerts this hypolipidemic phenotype was determined to include decreased very-low density lipoprotein secretion, decreased expression of hepatic lipogenic genes and increased fatty acid oxidation as determined by increased plasma ketone bodies and hepatic mitochondrial electron transport chain protein abundance. Fatty Acids 221-231 carboxylesterase 1 Homo sapiens 33-37 30901224-7 2019 Furthermore, dysregulation of CPS1, ASL, and ARG1, key enzymes involved in urea cycle, together with Annexin A6 and CES1, major proteins in regulating cholesterol homeostasis and fatty acid ester metabolism, was verified using immunohistochemical staining. Fatty Acids 179-195 carboxylesterase 1 Homo sapiens 116-120 20403742-1 2009 Carboxylesterases (CES) are responsible for the detoxification of a wide range of drugs and xenobiotics, and may contribute to cholesterol, fatty acid and lung surfactant metabolism. Fatty Acids 140-150 carboxylesterase 1 Homo sapiens 0-17 19761868-0 2010 Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Fatty Acids 129-140 carboxylesterase 1 Homo sapiens 92-110 19761868-5 2010 Here, we report the direct inhibitory effects of several endogenous oxysterols and fatty acids on the CE activity of THP1 monocytes/macrophages and recombinant human CES1 and CES2. Fatty Acids 83-94 carboxylesterase 1 Homo sapiens 166-170 19761868-9 2010 Furthermore, unsaturated fatty acids were better inhibitors of CES1 activity than saturated fatty acids, while CES2 activity was unaffected by any fatty acid. Fatty Acids 15-36 carboxylesterase 1 Homo sapiens 63-67 19761868-9 2010 Furthermore, unsaturated fatty acids were better inhibitors of CES1 activity than saturated fatty acids, while CES2 activity was unaffected by any fatty acid. Fatty Acids 25-35 carboxylesterase 1 Homo sapiens 63-67 19761868-10 2010 Arachidonic acid (AA) was the most potent fatty acid inhibitor of recombinant CES1 and acted by a noncompetitive mechanism (K(iapp)=1.7 microM); when not complexed to albumin, exogenous AA penetrated intact THP1 cells and inhibited CES1. Fatty Acids 42-52 carboxylesterase 1 Homo sapiens 78-82 24512105-10 2014 The enzyme encoded by CES1 is a major liver enzyme that typically catalyzes the decomposition of ester into alcohol and carboxylic acid and is involved in drug or xenobiotics, fatty acid, and cholesterol metabolisms. Fatty Acids 176-186 carboxylesterase 1 Homo sapiens 22-26 19761868-0 2010 Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids. Fatty Acids 129-140 carboxylesterase 1 Homo sapiens 14-30 32258948-4 2020 Mechanistically, human CES1 induced lipolysis and fatty acid oxidation, leading to a reduction in hepatic triglyceride and free fatty acid levels. Fatty Acids 50-60 carboxylesterase 1 Homo sapiens 23-27 17237500-6 2007 These data suggest that TGH plays a role in adipose tissue triacylglycerol metabolism and may be a suitable pharmacological target for lowering fatty acid efflux from adipose tissue without altering glucose import. Fatty Acids 144-154 carboxylesterase 1 Homo sapiens 24-27 12725862-1 2003 Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that plays important roles in narcotic metabolism, clinical prodrug activation, and the processing of fatty acid and cholesterol derivatives. Fatty Acids 167-177 carboxylesterase 1 Homo sapiens 6-24 12725862-1 2003 Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that plays important roles in narcotic metabolism, clinical prodrug activation, and the processing of fatty acid and cholesterol derivatives. Fatty Acids 167-177 carboxylesterase 1 Homo sapiens 26-30 7730302-2 1995 We examined the effect of in vitro fatty acid supplementation on low density lipoprotein (LDL) receptor activity in cultured cells and questioned whether changes were related to fatty acid-induced alterations in acyl-CoA: cholesterol acyltransferase (ACAT) activity. Fatty Acids 178-188 carboxylesterase 1 Homo sapiens 212-249 7730302-7 1995 We hypothesize that certain fatty acids delivered to cells either in free form, or as triglyceride, first increase cellular ACAT activity, which then causes a decrease in an intracellular free cholesterol pool, signaling a need for increased LDL receptor activity. Fatty Acids 28-39 carboxylesterase 1 Homo sapiens 124-128 34234263-1 2021 A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. Fatty Acids 176-187 carboxylesterase 1 Homo sapiens 104-122 34234263-1 2021 A recent genome-wide copy number variations (CNVs) scan identified a 16q12.2 deletion that included the carboxylesterase 1 (CES1) gene, which is important in the metabolism of fatty acids and cholesterol. Fatty Acids 176-187 carboxylesterase 1 Homo sapiens 124-128 33878036-6 2021 CES1 promoted CRC-cell survival via cell-autonomous mechanisms that fuel fatty-acid oxidation (FAO) and prevent the toxic build-up of triacylglycerols. Fatty Acids 73-83 carboxylesterase 1 Homo sapiens 0-4