PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11916926-5 2002 Delta-6 Desaturase mRNA and peroxisome proliferator-activated receptor gamma2 (PPARgamma2) mRNA were quantified by two-step RT-PCR, and the activity of the Delta-6 desaturase enzyme was estimated by gas chromatographic analysis of the omega 6-C18:3/C18:2 fatty acids ratio. Fatty Acids 255-266 fatty acid desaturase 2 Homo sapiens 156-174 10188593-0 1999 Differential effect of N-ethyl maleimide on delta6-desaturase activity in human fetal liver toward fatty acids of the n-6 and n-3 series. Fatty Acids 99-110 fatty acid desaturase 2 Homo sapiens 44-61 11290821-0 2001 Identification of a fatty acid delta6-desaturase deficiency in human skin fibroblasts. Fatty Acids 20-30 fatty acid desaturase 2 Homo sapiens 31-48 11240136-5 2001 These results suggest that desaturase genes could have, at least in part, independent control mechanisms and that Delta-6 desaturase impairment is not specific to any particular step of the fatty acid metabolic pathways, which may diminish the rationale for the existence of at least two distinct enzymes. Fatty Acids 190-200 fatty acid desaturase 2 Homo sapiens 114-132 10727010-6 2000 Fatty acid ratios of 18:3 n6/18:2 n6 indicated greater delta6-desaturase activity for women with type 2 diabetes, but differences were not found between pre- and post-menopausal groups. Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 55-72 9223654-0 1997 Delta-6-desaturase and delta-5-desaturase in human Hep G2 cells are both fatty acid interconversion rate limiting and are upregulated under essential fatty acid deficient conditions. Fatty Acids 73-83 fatty acid desaturase 2 Homo sapiens 0-18 8664338-13 1996 The verification of the involvement of two delta 6-desaturase activities in 22:6(n-3) synthesis would have important implications for the formulation of the nutritional requirements of this fatty acid during development. Fatty Acids 190-200 fatty acid desaturase 2 Homo sapiens 43-61 2129870-0 1990 Membrane fatty acid composition shows delta-6-desaturase abnormalities in Alzheimer"s disease. Fatty Acids 9-19 fatty acid desaturase 2 Homo sapiens 38-56 7833822-0 1994 The role of delta-6- and delta-9-desaturase in the fatty acid metabolism of hepatomas with different growth rate. Fatty Acids 51-61 fatty acid desaturase 2 Homo sapiens 12-43 8386433-0 1993 Fatty acid metabolism in health and disease: the role of delta-6-desaturase. Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 57-75 34520742-0 2022 FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication. Fatty Acids 16-26 fatty acid desaturase 2 Homo sapiens 0-5 34937850-5 2022 FADS2 silencing in cancer cells leads to FADS1 synthesis of unusual fatty acids. Fatty Acids 68-79 fatty acid desaturase 2 Homo sapiens 0-5 34937850-9 2022 SUMMARY: The mixture of fatty acids available to FADS2 in any tissue defines the product mixture available for further synthesis of membrane lipids and signaling molecules and may be relevant in many clinical conditions including cancer. Fatty Acids 24-35 fatty acid desaturase 2 Homo sapiens 49-54 34740033-11 2021 Expression of genes VLCAD and DGAT1, involved in fatty acid oxidation as well as DGAT1 in TAG synthesis, were significantly elevated after each cycle, whereas expression of genes ELOVL2 and FADS2, involved in fatty acid elongation and desaturation were significantly lower at D9 compared to D2 and D0 (P < 0.03). Fatty Acids 209-219 fatty acid desaturase 2 Homo sapiens 190-195 34303883-3 2021 Our objective was to examine the effect of estrogen and the "antiestrogen" aromatase inhibitor letrozole, on Delta5- and Delta6-desaturase synthesized fatty acids in vitro. Fatty Acids 151-162 fatty acid desaturase 2 Homo sapiens 127-138 33567271-0 2021 Apocryphal FADS2 activity promotes fatty acid diversification in cancer. Fatty Acids 35-45 fatty acid desaturase 2 Homo sapiens 11-16 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 4-27 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 29-34 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 49-67 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 69-72 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 131-134 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 396-399 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 448-453 35300779-1 2022 The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 557-562 34143495-5 2021 Hepatic gene expression of key enzymes of desaturation (Fads1/Fads2) of n-6 and n-3 polyunsaturated fatty acids (PUFAs), of phosphatidylethanolamine (PE) N-methyltransferase (Pemt), of fatty acid translocase Cd36, and of glucose-6-phosphate isomerase (Gpi) were quantified by Real Time-PCR. Fatty Acids 100-111 fatty acid desaturase 2 Homo sapiens 62-67 35211495-3 2021 Interactions are particularly relevant with the FADS1 and FADS2 genes, which encode key fatty acid desaturases in the pathway that converts LA and ALA to their long chain (>=20 carbons), highly unsaturated fatty acid (HUFA) counterparts. Fatty Acids 88-98 fatty acid desaturase 2 Homo sapiens 58-63 33904180-5 2021 Through a combination of immunofluorescence, pharmacological inhibition, tracing experiments with stable isotope-labeled fatty acids, and oxidant challenge with hydrogen peroxide, we demonstrate the presence and redox-sensitive activity of FADS2, FADS1, and FADS5 in the mature RBC. Fatty Acids 121-132 fatty acid desaturase 2 Homo sapiens 240-245 33310680-1 2021 Numerous studies have reported an association between genetic variants in fatty acid desaturases (FADS1 and FADS2) and plasma or erythrocyte long chain polyunsaturated fatty acid (PUFA) levels. Fatty Acids 74-84 fatty acid desaturase 2 Homo sapiens 108-113 32851475-4 2021 Furthermore, by assessing global protein levels changes, FADS2, a key enzyme regulating fatty acids synthesis, was found down-regulated after proteasome inhibition. Fatty Acids 88-99 fatty acid desaturase 2 Homo sapiens 57-62 33011673-2 2020 We hypothesized that the FADS2 gene variants will be associated with lower product-to-precursor ratio in the fatty acid metabolic pathways. Fatty Acids 109-119 fatty acid desaturase 2 Homo sapiens 25-30 32365195-0 2020 Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn"s Disease. Fatty Acids 15-25 fatty acid desaturase 2 Homo sapiens 51-56 33011673-12 2020 Addition of FADS2 alternative alleles was associated with lower plasma arachidonic acid (AA, C20:4 n-6, P < .001) and estimated desaturase-5 activity (P < .001), irrespective of gender, age, daily polyunsaturated/saturated fatty acid intake, and obesity. Fatty Acids 213-233 fatty acid desaturase 2 Homo sapiens 12-17 31751799-0 2020 Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids. Fatty Acids 87-108 fatty acid desaturase 2 Homo sapiens 0-23 32381429-10 2020 For PPAR-fatty acids metabolism pathways, the expression of seven randomly selected genes, including ACSBG1, ACOT2), CYP27A1, ELOVL3, FABP7, FADS2 and PPARG were all significantly decreased in psoriasis lesions. Fatty Acids 9-20 fatty acid desaturase 2 Homo sapiens 141-146 32731631-6 2020 Our results suggest that D6D is causally linked to cardiometabolic risk, which is likely due to downstream production of fatty acids and products resulting from high D6D activity. Fatty Acids 121-132 fatty acid desaturase 2 Homo sapiens 25-28 31751799-9 2020 We thus establish novel FADS2-coded enzymatic activity towards BCFA and n-OCFA, expanding the number of known FADS2 saturated fatty acid substrates from one to six. Fatty Acids 116-136 fatty acid desaturase 2 Homo sapiens 24-29 31751799-0 2020 Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids. Fatty Acids 87-108 fatty acid desaturase 2 Homo sapiens 25-30 31751799-9 2020 We thus establish novel FADS2-coded enzymatic activity towards BCFA and n-OCFA, expanding the number of known FADS2 saturated fatty acid substrates from one to six. Fatty Acids 116-136 fatty acid desaturase 2 Homo sapiens 110-115 32584610-0 2020 Association Between Genetic Variants in FADS1-FADS2 and ELOVL2 and Obesity, Lipid Traits, and Fatty Acids in Tunisian Population. Fatty Acids 94-105 fatty acid desaturase 2 Homo sapiens 46-51 31433740-0 2019 FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on Health. Fatty Acids 39-49 fatty acid desaturase 2 Homo sapiens 10-15 32584610-10 2020 These data suggest that variations in FADS1, FADS2, and ELOVL2 affect the risk of overweight-obesity and the level of circulating fatty acids and could point to a key molecular pathway of metabolic syndrome and its related comorbidities. Fatty Acids 130-141 fatty acid desaturase 2 Homo sapiens 45-50 31567872-0 2019 FADS1 and FADS2 polymorphism are associated with changes in fatty acid concentrations after calorie-restricted Central European and Mediterranean diets. Fatty Acids 60-70 fatty acid desaturase 2 Homo sapiens 10-15 31797636-7 2020 Seven SNPs were significant in association with dihomo-gamma-linolenic acid, of which five were within fatty acid desaturases FADS1 and FADS2. Fatty Acids 103-113 fatty acid desaturase 2 Homo sapiens 136-141 31030467-0 2019 Association of Delta-6-Desaturase Expression withAggressiveness of Cancer, Diabetes Mellitus, and MultipleSclerosis: A Narrative Review Background: The phosphatidylinositol 3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling regulates multiple cellular processes and organizes cell proliferation, survival, and differentiationwith the available nutrients, in particular, fatty acids. Fatty Acids 403-414 fatty acid desaturase 2 Homo sapiens 15-33 30082751-3 2019 The present study examined if SNPs in FADS1/FADS2 modify human subcutaneous adipose tissue (SAT) fatty acid profiles and the expression of genes associated with inflammation/immune function, lipid metabolism, and cellular differentiation. Fatty Acids 97-107 fatty acid desaturase 2 Homo sapiens 44-49 30654845-5 2019 RESULTS: We found a negative correlation between DNA methylation levels of cg06781209 and cg07999042 and hepatic FADS2 mRNA expression (both p < 0.05), and with estimated delta-6 desaturase activity based on both liver and serum fatty acids (all p < 0.05). Fatty Acids 232-243 fatty acid desaturase 2 Homo sapiens 113-118 30814093-2 2019 Instead of relying on the canonical SCD pathway for fatty-acid desaturation, the cells exploit a different enzyme, FADS2, and upregulate this alternative route when SCD is inhibited. Fatty Acids 52-62 fatty acid desaturase 2 Homo sapiens 115-120 29514873-5 2018 RESULTS: After running 33 separate FA fraction phenotypes, we found that SNPs known to be associated with serum FAs in the FADS1/2/3 region were also associated with breast milk FA composition (experiment-wise significance threshold 4.2x10-9). Fatty Acids 112-115 fatty acid desaturase 2 Homo sapiens 123-132 30157936-0 2018 FADS1-FADS2 genetic polymorphisms are associated with fatty acid metabolism through changes in DNA methylation and gene expression. Fatty Acids 54-64 fatty acid desaturase 2 Homo sapiens 6-11 30103922-9 2018 Delta-6-desaturase (D6D) activity index, calculated using fatty acid ratios, was 9% lower in pre-existing diabetes than in controls (p = 0.042). Fatty Acids 58-68 fatty acid desaturase 2 Homo sapiens 0-18 30103922-9 2018 Delta-6-desaturase (D6D) activity index, calculated using fatty acid ratios, was 9% lower in pre-existing diabetes than in controls (p = 0.042). Fatty Acids 58-68 fatty acid desaturase 2 Homo sapiens 20-23 26597785-3 2016 Our aim was to characterize the competition for accessing FADS2 mediated Delta6 desaturation between 16:0 and the most abundant polyunsaturated fatty acids (PUFA) in the human diet, 18:2n-6 and 18:3n-3, to evaluate whether competition may be relevant in other tissues and thus linked to metabolic abnormalities associated with FADS2 or fatty acid levels. Fatty Acids 144-154 fatty acid desaturase 2 Homo sapiens 58-63 27004414-0 2016 Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease. Fatty Acids 46-57 fatty acid desaturase 2 Homo sapiens 27-32 29246731-6 2018 RESULTS: We identified 24 previously reported SNPs associated with fatty acid levels and desaturase activities as significantly associated with D5D activity within the FADS1-FADS2 gene cluster (lead SNP rs174566/A>G). Fatty Acids 67-77 fatty acid desaturase 2 Homo sapiens 174-179 26597785-3 2016 Our aim was to characterize the competition for accessing FADS2 mediated Delta6 desaturation between 16:0 and the most abundant polyunsaturated fatty acids (PUFA) in the human diet, 18:2n-6 and 18:3n-3, to evaluate whether competition may be relevant in other tissues and thus linked to metabolic abnormalities associated with FADS2 or fatty acid levels. Fatty Acids 144-154 fatty acid desaturase 2 Homo sapiens 327-332 26455892-3 2015 The prenatal environment may differentially affect the substrates supporting declarative memory abilities, as the level of fatty acids transferred across the placenta may be affected by the maternal fatty acid desaturase 2 (FADS2) rs174575 single nucleotide polymorphism. Fatty Acids 123-134 fatty acid desaturase 2 Homo sapiens 199-222 26474818-2 2015 These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Delta-5 (encoded by FADS1) and Delta-6 desaturases (encoded by FADS2). Fatty Acids 6-17 fatty acid desaturase 2 Homo sapiens 172-177 26455892-3 2015 The prenatal environment may differentially affect the substrates supporting declarative memory abilities, as the level of fatty acids transferred across the placenta may be affected by the maternal fatty acid desaturase 2 (FADS2) rs174575 single nucleotide polymorphism. Fatty Acids 123-134 fatty acid desaturase 2 Homo sapiens 224-229 25497832-2 2015 The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif. Fatty Acids 111-121 fatty acid desaturase 2 Homo sapiens 48-53 26087436-7 2015 In multiple regression models, PCB exposure was inversely related to the estimated Delta6 desaturase activity resulting in accumulation of precursor fatty acids and decrease in the corresponding product PUFAs. Fatty Acids 149-160 fatty acid desaturase 2 Homo sapiens 89-100 26065859-2 2015 The biosynthesis of Delta4-desaturated docosanoid fatty acids 22:6n-3 and 22:5n-6 are believed to proceed via a circuitous biochemical pathway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta6 desaturation on C24 fatty acids in the endoplasmic reticulum followed by 1 round of beta-oxidation in the peroxisomes. Fatty Acids 50-61 fatty acid desaturase 2 Homo sapiens 171-194 26065859-2 2015 The biosynthesis of Delta4-desaturated docosanoid fatty acids 22:6n-3 and 22:5n-6 are believed to proceed via a circuitous biochemical pathway requiring repeated use of a fatty acid desaturase 2 (FADS2) protein to perform Delta6 desaturation on C24 fatty acids in the endoplasmic reticulum followed by 1 round of beta-oxidation in the peroxisomes. Fatty Acids 50-61 fatty acid desaturase 2 Homo sapiens 196-201 26065859-6 2015 Similarly, FADS2 stable cells when incubated with d5-18:3n-3 show synthesis of d5-22:6n-3 with no labeling of 24:5n-3 or 24:6n-3 at 24 h. Further, both C24 fatty acids are shown to be products of the respective C22 fatty acids via elongation. Fatty Acids 156-167 fatty acid desaturase 2 Homo sapiens 11-16 26065859-6 2015 Similarly, FADS2 stable cells when incubated with d5-18:3n-3 show synthesis of d5-22:6n-3 with no labeling of 24:5n-3 or 24:6n-3 at 24 h. Further, both C24 fatty acids are shown to be products of the respective C22 fatty acids via elongation. Fatty Acids 215-226 fatty acid desaturase 2 Homo sapiens 11-16 25497832-2 2015 The protein sequence of yellow catfish SCD1 and Fads2 (Delta6) possessed all the characteristics of microsomal fatty acid Fads2 (Delta6), including three histidine boxes, two transmembrane regions and one N-terminal cytochrome b5 domain containing heme-binding motif. Fatty Acids 111-121 fatty acid desaturase 2 Homo sapiens 122-127 25549244-0 2014 Loss of FADS2 function severely impairs the use of HeLa cells as an in vitro model for host response studies involving fatty acid effects. Fatty Acids 119-129 fatty acid desaturase 2 Homo sapiens 8-13 25122663-10 2014 Additional findings include associations between endogenously synthesized fatty acids and CHD risk, which were partly explained by changes in Delta6-desaturase and Delta5-desaturase indexes, suggesting that in vivo metabolism may also play an important role in predicting CHD risk in this cohort of postmenopausal women. Fatty Acids 74-85 fatty acid desaturase 2 Homo sapiens 148-159 23737301-3 2013 It has been suggested that the effect on IQ is moderated by polymorphisms in the FADS2 gene, which is involved in fatty acid metabolism. Fatty Acids 114-124 fatty acid desaturase 2 Homo sapiens 81-86 24460221-3 2014 The biosynthesis of unsaturated fatty acids (UFA) requires the expression of dietary fat-associated genes, such as SCD, FADS1, FADS2, and FADS3, which encode a variety of desaturases, to catalyze the addition of a double bond in a fatty acid chain. Fatty Acids 32-42 fatty acid desaturase 2 Homo sapiens 127-132 24284026-2 2014 We examined the hypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain polyunsaturated fatty acid biosynthesis, mediates the signature pattern of fatty acid redistribution observed in myocardial phospholipids after chronic pressure overload and explored plausible links between this process and disease pathogenesis. Fatty Acids 113-123 fatty acid desaturase 2 Homo sapiens 32-50 24284026-2 2014 We examined the hypothesis that delta-6 desaturase (D6D), the rate-limiting enzyme in long-chain polyunsaturated fatty acid biosynthesis, mediates the signature pattern of fatty acid redistribution observed in myocardial phospholipids after chronic pressure overload and explored plausible links between this process and disease pathogenesis. Fatty Acids 113-123 fatty acid desaturase 2 Homo sapiens 52-55 24391980-2 2013 The biosynthesis of DHA is the most difficult, because this undergoes the Sprecher pathway--a further elongation step from docosapentaenoic acid (DPA), a Delta6-desaturase acting on a C24 fatty acid substrate followed by a peroxisomal chain shortening step. Fatty Acids 188-198 fatty acid desaturase 2 Homo sapiens 160-171 24067669-9 2013 The endogenous synthesis of these FAs by FADS genes, especially FADS2, may also be important. Fatty Acids 34-37 fatty acid desaturase 2 Homo sapiens 64-69 24294133-1 2013 The Delta6-desaturase (Delta6D), also known as fatty acid desaturase 2, is a regulatory enzyme in de novo fatty acid synthesis, which has been linked to obesity and diabetes. Fatty Acids 47-57 fatty acid desaturase 2 Homo sapiens 10-21 24294133-1 2013 The Delta6-desaturase (Delta6D), also known as fatty acid desaturase 2, is a regulatory enzyme in de novo fatty acid synthesis, which has been linked to obesity and diabetes. Fatty Acids 47-57 fatty acid desaturase 2 Homo sapiens 23-30 24847668-2 2014 The fatty acid composition is modulated by desaturases; stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 4-14 fatty acid desaturase 2 Homo sapiens 87-105 24847668-2 2014 The fatty acid composition is modulated by desaturases; stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 4-14 fatty acid desaturase 2 Homo sapiens 107-110 23221573-1 2013 BACKGROUND: Desaturation of dietary alpha-linolenic acid (ALA) to omega-3 (n-3) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition. Fatty Acids 104-107 fatty acid desaturase 2 Homo sapiens 151-156 23826354-0 2013 FADS2 Genetic Variance in Combination with Fatty Acid Intake Might Alter Composition of the Fatty Acids in Brain. Fatty Acids 92-103 fatty acid desaturase 2 Homo sapiens 0-5 23667444-1 2013 OBJECTIVE: Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. Fatty Acids 71-81 fatty acid desaturase 2 Homo sapiens 100-105 23419767-1 2013 Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 186-204 23419767-1 2013 Fatty acid composition, which is altered in patients with abdominal obesity, is influenced not only by dietary intake but also by the desaturating enzymes stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 206-209 21629299-4 2011 We examined correlations between rs3834458 variants and fatty acid evidence of FADS2 activity in a cohort of rheumatoid arthritis patients selected for low or nil consumption of n-3 LCPUFA as fish or fish oil. Fatty Acids 56-66 fatty acid desaturase 2 Homo sapiens 79-84 22619218-0 2012 A novel FADS1 isoform potentiates FADS2-mediated production of eicosanoid precursor fatty acids. Fatty Acids 84-95 fatty acid desaturase 2 Homo sapiens 34-39 22503634-3 2012 To determine the importance of genetic variability to fatty-acid biosynthesis, we studied FADS1 and FADS2, which encode rate-limiting enzymes for fatty-acid conversion. Fatty Acids 146-156 fatty acid desaturase 2 Homo sapiens 100-105 22863834-1 2012 AIMS: Plasma fatty acid composition can change with age, reflecting diet and levels of desaturating enzymes such as stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D), which contribute to the development of insulin resistance. Fatty Acids 13-23 fatty acid desaturase 2 Homo sapiens 147-165 22863834-1 2012 AIMS: Plasma fatty acid composition can change with age, reflecting diet and levels of desaturating enzymes such as stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D), which contribute to the development of insulin resistance. Fatty Acids 13-23 fatty acid desaturase 2 Homo sapiens 167-170 22119675-2 2011 These fatty acids belong to the n-10 series and the initial step involved in their synthesis is the desaturation of palmitic acid by the Delta6-desaturase to form sapienic acid. Fatty Acids 6-17 fatty acid desaturase 2 Homo sapiens 143-154 21679695-5 2011 Subsequently, the heterologous expression of borage Delta6-desaturase was evaluated by fatty acid analysis. Fatty Acids 87-97 fatty acid desaturase 2 Homo sapiens 58-69 21106917-1 2011 BACKGROUND: Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Delta5-desaturase and Delta6-desaturase. Fatty Acids 221-232 fatty acid desaturase 2 Homo sapiens 282-293 21414826-1 2011 Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been examined in different ethnic populations. Fatty Acids 52-62 fatty acid desaturase 2 Homo sapiens 94-99 21414826-1 2011 Recent evidence indicates that genetic variation in fatty acid desaturases 1 and 2 (FADS1 and FADS2) is associated with changes in plasma fatty acid profiles; however, the association with altered desaturase activity has not been examined in different ethnic populations. Fatty Acids 138-148 fatty acid desaturase 2 Homo sapiens 94-99 21106917-1 2011 BACKGROUND: Blood and tissue long-chain polyunsaturated fatty acid (LC-PUFA) amounts, which have been associated with early development and lifelong health, depend on dietary intake and endogenous conversion of precursor fatty acids (FAs) by the enzymes Delta5-desaturase and Delta6-desaturase. Fatty Acids 234-237 fatty acid desaturase 2 Homo sapiens 282-293 21106917-2 2011 Polymorphisms in the desaturase encoding genes FADS1 and FADS2 have been associated with several n-6 (omega-6) and n-3 (omega-3) FAs and especially with arachidonic acid (AA) amounts. Fatty Acids 129-132 fatty acid desaturase 2 Homo sapiens 57-62 20427696-0 2010 Single nucleotide polymorphisms in the FADS gene cluster are associated with delta-5 and delta-6 desaturase activities estimated by serum fatty acid ratios. Fatty Acids 138-148 fatty acid desaturase 2 Homo sapiens 39-107 21307609-2 2011 Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D) modulate fatty acid composition and are thus associated with the development of metabolic syndrome. Fatty Acids 116-126 fatty acid desaturase 2 Homo sapiens 53-71 21307609-2 2011 Desaturating enzymes, stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D) modulate fatty acid composition and are thus associated with the development of metabolic syndrome. Fatty Acids 116-126 fatty acid desaturase 2 Homo sapiens 73-76 20948998-1 2010 BACKGROUND: Association of genetic-variants in the FADS1-FADS2-gene-cluster with fatty-acid-composition in blood of adult-populations is well established. Fatty Acids 81-91 fatty acid desaturase 2 Homo sapiens 57-62 18479586-0 2009 Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes. Fatty Acids 60-70 fatty acid desaturase 2 Homo sapiens 116-121 19944404-7 2009 The top two SNPs with the greatest frequency differences between the northern Han and southern Han clusters (F(ST) > 0.06) were found in the FADS2 gene, which associates with the fatty acid composition in phospholipids, and in the HLA complex P5 gene (HCP5), which associates with HIV infection, psoriasis, and psoriatic arthritis. Fatty Acids 182-192 fatty acid desaturase 2 Homo sapiens 144-149 19195843-0 2009 Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Fatty Acids 128-138 fatty acid desaturase 2 Homo sapiens 9-27 19195843-0 2009 Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Fatty Acids 128-138 fatty acid desaturase 2 Homo sapiens 29-34 18479586-1 2009 The present study gives further evidence for the recently found association between variants of the fatty acid desaturase 1 fatty acid desaturase 2 (FADS1 FADS2) gene cluster and PUFA in blood phospholipids and explores this association for cellular fatty acids in erythrocyte membranes. Fatty Acids 250-261 fatty acid desaturase 2 Homo sapiens 155-160 18400734-0 2008 The interaction between intestinal fatty acid-binding protein 2 polymorphism and delta-6 desaturase activity in obese children. Fatty Acids 35-45 fatty acid desaturase 2 Homo sapiens 81-99 17984066-4 2007 Here we show that the association between breastfeeding and IQ is moderated by a genetic variant in FADS2, a gene involved in the genetic control of fatty acid pathways. Fatty Acids 149-159 fatty acid desaturase 2 Homo sapiens 100-105 18626191-5 2008 Our data demonstrate for the first time that the fatty acid composition of serum phospholipids is genetically controlled by the FADS1 FADS2 gene cluster. Fatty Acids 49-59 fatty acid desaturase 2 Homo sapiens 134-139 17960445-1 2008 The effect of unsaturated fatty acids on the abundance of Delta6 desaturase (D6D) mRNA and the fatty acid composition of HepG2 cell membranes was examined. Fatty Acids 26-36 fatty acid desaturase 2 Homo sapiens 64-75 17960445-1 2008 The effect of unsaturated fatty acids on the abundance of Delta6 desaturase (D6D) mRNA and the fatty acid composition of HepG2 cell membranes was examined. Fatty Acids 26-36 fatty acid desaturase 2 Homo sapiens 77-80 12951357-0 2003 A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. Fatty Acids 93-103 fatty acid desaturase 2 Homo sapiens 67-72 16670158-0 2006 Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Fatty Acids 115-125 fatty acid desaturase 2 Homo sapiens 37-42 16670158-2 2006 We report strong associations between variants in the human delta-5 and delta-6 desaturase genes FADS1 FADS2 and fatty acid composition in serum phospholipids. Fatty Acids 113-123 fatty acid desaturase 2 Homo sapiens 60-90 16670158-2 2006 We report strong associations between variants in the human delta-5 and delta-6 desaturase genes FADS1 FADS2 and fatty acid composition in serum phospholipids. Fatty Acids 113-123 fatty acid desaturase 2 Homo sapiens 103-108 17892040-12 2007 delta6-desaturase (transformes linolenic acid into gamma-linolenic acid by making additional double bond) is the slowest step of the fatty acid metabolism. Fatty Acids 133-143 fatty acid desaturase 2 Homo sapiens 0-17 14748719-6 2004 This Delta6-desaturase acts on a saturated fatty acid, palmitic acid (C(16:0)), leading to the newly characterized biosynthesis of hexadecenoic acid (C(16:1) n-10) or sapienate. Fatty Acids 33-53 fatty acid desaturase 2 Homo sapiens 11-22 12951357-0 2003 A nucleotide insertion in the transcriptional regulatory region of FADS2 gives rise to human fatty acid delta-6-desaturase deficiency. Fatty Acids 93-103 fatty acid desaturase 2 Homo sapiens 104-122 12951357-1 2003 Fatty acid delta-6-desaturase (FADS2) is the rate-limiting enzyme in mammalian synthesis of long-chain polyunsaturated fatty acids. Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 11-29 12951357-1 2003 Fatty acid delta-6-desaturase (FADS2) is the rate-limiting enzyme in mammalian synthesis of long-chain polyunsaturated fatty acids. Fatty Acids 0-10 fatty acid desaturase 2 Homo sapiens 31-36 12951357-7 2003 These findings indicate that fatty acid delta-6-desaturase deficiency and decreased FADS2 transcription are caused by a nucleotide insertion in the transcriptional regulatory region of the human FADS2 gene. Fatty Acids 29-39 fatty acid desaturase 2 Homo sapiens 40-58 12951357-7 2003 These findings indicate that fatty acid delta-6-desaturase deficiency and decreased FADS2 transcription are caused by a nucleotide insertion in the transcriptional regulatory region of the human FADS2 gene. Fatty Acids 29-39 fatty acid desaturase 2 Homo sapiens 195-200 12544656-7 2003 RECENT FINDINGS: Insulin resistance and insulin resistant states are often associated with the fatty acid pattern in plasma, characterized by an increased proportion of palmitic (16 : 0) and a low proportion of linoleic (18 : 2 n-6) acids, with a distribution of other fatty acids indicating an increased activity of delta-9 and delta-6 desaturase. Fatty Acids 95-105 fatty acid desaturase 2 Homo sapiens 317-347