PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34049969-6 2021 Importantly, plasma IL-6 and C-reactive protein (CRP) levels positively correlated with mitochondrial mass and negatively correlated with fatty acid uptake in T cells from COVID-19 patients. Fatty Acids 138-148 interleukin 6 Homo sapiens 20-24 32559180-5 2020 Interestingly, metabolite levels in these pathways correlated with clinical laboratory markers of inflammation (i.e., IL-6 and C-reactive protein) and renal function (i.e., blood urea nitrogen).CONCLUSIONIn conclusion, this initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.FUNDINGBoettcher Foundation Webb-Waring Biomedical Research Award; National Institute of General and Medical Sciences, NIH; and National Heart, Lung, and Blood Institute, NIH. Fatty Acids 278-288 interleukin 6 Homo sapiens 118-122 33479266-8 2021 Finally, the multi-omic integrative analysis suggested a relationship between cytokines CCL20, CX3CL1, CXCL13, IL-15, IL-22 and IL-6 with alteration in chemotaxis, as well as a link between long-chain unsaturated phospholipids and the increased fatty acid transport and prostaglandin production. Fatty Acids 245-255 interleukin 6 Homo sapiens 128-132 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 interleukin 6 Homo sapiens 244-257 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 interleukin 6 Homo sapiens 259-263 31787367-7 2020 Obesity and diet composition were both positively associated to pro-inflammatory biomarkers, CRP and IL1b; while diet composition shared with physical activity levels the correlation with IL6 (positive with energy, fat, carbohydrate and saturated fatty acid intake, and negative with cholesterol intake and average physical activity in boys), NGF and glucose (in both cases correlations were negative with diet composition and physical activity variables) (P < 0.05, in all cases). Fatty Acids 247-257 interleukin 6 Homo sapiens 188-191 29801502-7 2018 Fatty acids decreased the level of IL-6 and TNFalpha in supernatant in a ratio-dependent manner. Fatty Acids 0-11 interleukin 6 Homo sapiens 35-39 31788012-0 2019 Plasma concentration of interleukin-6 was upregulated in cancer cachexia patients and was positively correlated with plasma free fatty acid in female patients. Fatty Acids 129-139 interleukin 6 Homo sapiens 24-37 31222133-2 2019 Because the cytokines TNFalpha and IL-6 are key signals in HFD- and SFA-induced proinflammatory responses that ultimately lead to systemic insulin resistance, the present study examined the roles of these cytokines in the feedback modulation of peripheral circadian clocks by the proinflammatory SFA, palmitate. Fatty Acids 68-71 interleukin 6 Homo sapiens 35-39 31222133-6 2019 These studies suggest that TNFalpha, IL-6 and other proinflammatory cytokines may mediate the feedback modulation of peripheral circadian clocks by SFA-induced inflammatory signaling. Fatty Acids 148-151 interleukin 6 Homo sapiens 37-41 32528464-7 2020 Incubation of healthy and SSc dendritic cells with etoposide, a carnitine transporter inhibitor, inhibited the production of pro-inflammatory cytokines such as IL-6 through inhibition of fatty acid oxidation. Fatty Acids 187-197 interleukin 6 Homo sapiens 160-164 32511571-0 2020 COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status. Fatty Acids 72-82 interleukin 6 Homo sapiens 114-118 31028903-5 2019 Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11. Fatty Acids 56-67 interleukin 6 Homo sapiens 415-418 30648905-6 2019 In epithelial cells, palmitic acid (SFA) combined with poly(I:C) also led to greater IL-6 release. Fatty Acids 36-39 interleukin 6 Homo sapiens 85-89 30866565-5 2019 Several fatty acids were associated with interferon-gamma (IFNgamma) and interleukins (ILs) IL-6, IL-8, and IL-10 at baseline and additionally also with IL-1b at 1 year. Fatty Acids 8-19 interleukin 6 Homo sapiens 92-96 28481867-6 2017 The mechanism whereby RB inactivation increases IL-6 production in MCF-7 cells appeared to involve fatty acid oxidation (FAO)-dependent mitochondrial metabolism and c-Jun NH(2)-terminal kinase (JNK). Fatty Acids 99-109 interleukin 6 Homo sapiens 48-52 29330220-9 2018 The most striking effects of IL-6 and/or fatty acid treatment were observed in HepaRG cells after 14 days of treatment, making these cultures appear a suitable model for studying the relationship of fatty acid accumulation, inflammation, and xenobiotic-induced drug metabolism. Fatty Acids 199-209 interleukin 6 Homo sapiens 29-33 29258201-4 2017 Supplementation of the culture medium with particular fatty acids was found to have a promoting effect on cellular production of the cytokines IL-6, IL-8, GM-CSF, and MCP-1. Fatty Acids 54-65 interleukin 6 Homo sapiens 143-147 27539101-5 2016 Many significant associations were found between the increase of IL-6, resp. SAA and the amounts of n-6 polyunsaturated fatty acids (namely linoleic, dihomo-gamma-linolenic, docosatetraenoic and docosapentaenoic acid), resp. saturated fatty acids (pentadecanoic, stearic, nonadecanoic) in erythrocyte membranes. Fatty Acids 110-131 interleukin 6 Homo sapiens 65-69 26164553-8 2016 Depending on the environmental or human origin the structures differed in the length and degree of fatty acid acylation and impacted the IL-6 and TNF-alpha inflammatory responses tested. Fatty Acids 99-109 interleukin 6 Homo sapiens 137-141 26923510-2 2016 We hypothesized that inflammatory markers interleukin (IL)-6 and C-reactive protein (CRP) mediate the associations between antioxidant and fatty acid intakes, and depression. Fatty Acids 139-149 interleukin 6 Homo sapiens 42-60 27003399-4 2016 Similarly, adiponectin, leptin and IL-6 enhance glucose uptake and increase fatty acid oxidation in skeletal muscle. Fatty Acids 76-86 interleukin 6 Homo sapiens 35-39 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Fatty Acids 143-154 interleukin 6 Homo sapiens 325-342 26333527-7 2015 IL-6, IL-8, IL-1beta and TNF-alpha concentration in NBL showed inverse correlation coefficients with the peroxidation products of fatty acids. Fatty Acids 130-141 interleukin 6 Homo sapiens 0-4 25546122-3 2015 The purpose of this review is to highlight and evaluate novel mechanisms by which dietary pro-oxidants, including bioactive phytochemicals and fatty acids, increase reactive oxygen species (ROS) concentrations just enough to activate transcription factor activation of nuclear factor erythroid 2 related factor 2 (Nrf-2) and heat shock factor (HSF), leading to an increase in levels of antioxidant enzymes and heat shock proteins that protect against the damaging effects of ROS. Fatty Acids 143-154 interleukin 6 Homo sapiens 344-347 24285492-11 2015 Extracellular and intracellular TLR4 inhibition as well as fatty acid transport inhibition blocked the palmitic acid-induced IL-6 secretion of RASF. Fatty Acids 59-69 interleukin 6 Homo sapiens 125-129 18059606-3 2007 IL-6 increases insulin-stimulated glucose disposal and fatty acid oxidation in humans in vivo. Fatty Acids 55-65 interleukin 6 Homo sapiens 0-4 25221751-3 2014 This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (IL-6) and high sensitivity C-reactive protein (hs-CRP), in CAD patients among Iranian population. Fatty Acids 68-78 interleukin 6 Homo sapiens 113-126 25221751-3 2014 This study was conducted to examine the association between dietary fatty acid intakes and inflammatory markers, interleukin 6 (IL-6) and high sensitivity C-reactive protein (hs-CRP), in CAD patients among Iranian population. Fatty Acids 68-78 interleukin 6 Homo sapiens 128-132 25221751-8 2014 After adjustment for potential confounders, SFA was directly related to hs-CRP (P = 0.01) and IL-6 (P < 0.001) concentrations. Fatty Acids 44-47 interleukin 6 Homo sapiens 94-98 23990363-6 2014 Haploinsufficiency and short hairpin RNA-based knockdown of ATF4 in macrophages markedly inhibited SFA- and metabolic stress-induced Il6 expression. Fatty Acids 99-102 interleukin 6 Homo sapiens 133-136 22677645-9 2012 For men only there were significant (at least P < 0.05), positive correlations between adipocyte Cer-containing saturated fatty acid and plasma IL-6 concentration. Fatty Acids 115-135 interleukin 6 Homo sapiens 147-151 21907687-11 2012 Lipid accumulation in hepatocytes, induced by incubation with fatty acids, was associated with increased CML formation and expression of the receptor for advanced glycation endproducts (RAGE), PAI-1, IL-8, IL-6, and CRP. Fatty Acids 62-73 interleukin 6 Homo sapiens 206-210 22319624-14 2012 Both fatty acids appeared to abolish H2O2 mediated stimulation of nuclear factor kappaB and IL-6, but not IL-1alpha and IL-8. Fatty Acids 5-16 interleukin 6 Homo sapiens 92-96 21257314-7 2011 This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1beta, IL-6, and TNF-alpha) and the chemokine MDC. Fatty Acids 66-76 interleukin 6 Homo sapiens 160-164 17956334-7 2007 IL-6 treatment of myotubes increases fatty acid oxidation, basal and insulin-stimulated glucose uptake and translocation of GLUT4 to the plasma membrane. Fatty Acids 37-47 interleukin 6 Homo sapiens 0-4 25468541-6 2015 RESULTS: Pre-exposure to n-3 PUFAs as individual fatty acids results in reduced placental IL-6 production (P < 0.05), whereas exposure to complex fatty acid mixtures enriched in n-3 PUFAs (high n-3:n-6 ratios) results in a significant stimulation of IL-6 production (P < 0.05). Fatty Acids 49-60 interleukin 6 Homo sapiens 90-94 25468541-6 2015 RESULTS: Pre-exposure to n-3 PUFAs as individual fatty acids results in reduced placental IL-6 production (P < 0.05), whereas exposure to complex fatty acid mixtures enriched in n-3 PUFAs (high n-3:n-6 ratios) results in a significant stimulation of IL-6 production (P < 0.05). Fatty Acids 49-59 interleukin 6 Homo sapiens 90-94 24911931-6 2014 Fatty acid exposure at 2 and 4 h increased both monocyte chemoattractant protein-1 and interleukin-6 gene expression levels in preadipocytes to greater levels than in mature adipocytes. Fatty Acids 0-10 interleukin 6 Homo sapiens 87-100 24168453-4 2013 Though all fatty acids tested produced changes in the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), lipoxin A4 and free radical generation by RWPE-1 and PC-3 cells, there were significant differences in their ability to do so. Fatty Acids 11-22 interleukin 6 Homo sapiens 68-81 24168453-4 2013 Though all fatty acids tested produced changes in the production of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), lipoxin A4 and free radical generation by RWPE-1 and PC-3 cells, there were significant differences in their ability to do so. Fatty Acids 11-22 interleukin 6 Homo sapiens 83-87 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. Fatty Acids 47-68 interleukin 6 Homo sapiens 179-183 23698162-3 2013 In summary, dietary fatty acids, in particular saturated fatty acids and the omega-3 and omega-6 polyunsaturated fatty acids, impact the expression of the cytokine genes TNFA and IL-6, and alter TNFalpha and IL-6 production. Fatty Acids 47-68 interleukin 6 Homo sapiens 208-212 23086036-5 2013 IL-6 increased fatty acid oxidation in myotubes from type 2 diabetic and normal glucose tolerant subjects. Fatty Acids 15-25 interleukin 6 Homo sapiens 0-4 23844276-6 2013 Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha , IL-1 beta , and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA. Fatty Acids 21-42 interleukin 6 Homo sapiens 169-173 22334674-4 2012 Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfalpha, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. Fatty Acids 175-196 interleukin 6 Homo sapiens 84-87 21144584-0 2011 Effect of IL-6 and TNF-alpha on fatty acid uptake in cultured human primary trophoblast cells. Fatty Acids 32-42 interleukin 6 Homo sapiens 10-14 21144584-4 2011 In cultured primary human trophoblast cells IL-6, but not TNF-alpha, stimulated fatty acid accumulation, as measured by BODIPY fluorescence. Fatty Acids 80-90 interleukin 6 Homo sapiens 44-48 21144584-8 2011 In conclusion, high levels of IL-6 stimulate trophoblast fatty acid accumulation, which could contribute to an excessive nutrient transfer in conditions associated with elevated maternal IL-6 such as obesity and gestational diabetes. Fatty Acids 57-67 interleukin 6 Homo sapiens 30-34 21144584-8 2011 In conclusion, high levels of IL-6 stimulate trophoblast fatty acid accumulation, which could contribute to an excessive nutrient transfer in conditions associated with elevated maternal IL-6 such as obesity and gestational diabetes. Fatty Acids 57-67 interleukin 6 Homo sapiens 187-191 20526368-15 2010 Induction of IL-6 in human bladder smooth muscle cells by fatty acids may represent a pathogenetic factor underlying the higher frequency and persistence of urinary tract infections in patients with metabolic diseases. Fatty Acids 58-69 interleukin 6 Homo sapiens 13-17 20110572-4 2010 METHODS AND RESULTS: THP-1 monocytes exposed to 100 micromol/L SFA in vitro for 16 hours followed by 1 ng/mL lipopolysaccharide demonstrated enhanced IL-6 and IL-8 mRNA and protein expression (approximately 3-fold higher than the sum of individual responses to SFA and lipopolysaccharide). Fatty Acids 63-66 interleukin 6 Homo sapiens 150-154 17003332-4 2006 IL-6 treatment increased fatty acid oxidation, basal and insulin-stimulated glucose uptake, and translocation of GLUT4 to the plasma membrane. Fatty Acids 25-35 interleukin 6 Homo sapiens 0-4 17003332-0 2006 Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Fatty Acids 93-103 interleukin 6 Homo sapiens 0-13 17615159-2 2007 This IL-6 production is discussed as one possible mediator of the beneficial effects of physical activity on glucose and fatty acid metabolism. Fatty Acids 121-131 interleukin 6 Homo sapiens 5-9 16945991-4 2006 IL-6 increased glucose incorporation into glycogen, glucose uptake, lactate production, and fatty acid uptake and oxidation, concomitant with increased phosphorylation of AMP-activated protein kinase (AMPK), signal transducer and activator of transcription 3, and ERK1/2. Fatty Acids 92-102 interleukin 6 Homo sapiens 0-4 16945991-7 2006 The small interfering RNA-directed depletion of AMPK reduced IL-6-mediated fatty acid oxidation and palmitate uptake but did not reduce glycogen synthesis. Fatty Acids 75-85 interleukin 6 Homo sapiens 61-65 17003332-8 2006 Our results demonstrate that acute IL-6 treatment enhances insulin-stimulated glucose disposal in humans in vivo, while the effects of IL-6 on glucose and fatty acid metabolism in vitro appear to be mediated by AMPK. Fatty Acids 155-165 interleukin 6 Homo sapiens 135-139 15741245-1 2005 The present study examined the role of the cytokine IL-6 in the regulation of fatty acid metabolism during exercise in humans. Fatty Acids 78-88 interleukin 6 Homo sapiens 52-56 15843537-4 2005 The results presented in this study demonstrate that the saturated fatty acid, lauric acid, up-regulates the expression of costimulatory molecules (CD40, CD80, and CD86), MHC class II, and cytokines (IL-12p70 and IL-6) in bone marrow-derived DCs. Fatty Acids 57-77 interleukin 6 Homo sapiens 213-217 15383370-9 2005 Acute IL-6 treatment increased fatty acid turnover in D patients as well as healthy CON subjects. Fatty Acids 31-41 interleukin 6 Homo sapiens 6-10 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Fatty Acids 169-180 interleukin 6 Homo sapiens 127-131 15383370-0 2005 Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro. Fatty Acids 31-41 interleukin 6 Homo sapiens 6-10 15304377-2 2004 Because 1) IL-6 mRNA expression in contracting skeletal muscle is enhanced by low muscle glycogen content, and 2) IL-6 increases lipolysis and oxidation of fatty acids, we hypothesized that regular exercise training, associated with increased levels of resting muscle glycogen and enhanced capacity to oxidize fatty acids, would lead to a less-pronounced increase of skeletal muscle IL-6 mRNA in response to acute exercise. Fatty Acids 169-180 interleukin 6 Homo sapiens 127-131 10204831-10 1999 Furthermore, endothelial cell production of IL-6 was increased in zinc-deficient endothelial cells following treatment with fatty acids or TNF. Fatty Acids 124-135 interleukin 6 Homo sapiens 44-48 12181307-10 2002 The temporal profile of the post-exercise change in the IL-6 output closely resembles the changes in the outputs of glycerol and fatty acids, which we have described previously in the same adipose tissue depot. Fatty Acids 129-140 interleukin 6 Homo sapiens 56-60 12181307-12 2002 Thus, we suggest that the enhanced IL-6 production post-exercise in abdominal, subcutaneous adipose tissue may act locally via autocrine/paracrine mechanisms influencing lipolysis and fatty acid mobilization rate from this lipid depot. Fatty Acids 184-194 interleukin 6 Homo sapiens 35-39 12716789-5 2003 RESULTS: The percentage of saturated FAs (r = 0.30, P = 0.01) and omega-6 FAs (r = -0.32, P = 0.001) were significantly associated with circulating IL-6, whereas the percentage of omega-3 FAs correlated negatively with C-reactive protein in overweight subjects (P = 0.04). Fatty Acids 37-40 interleukin 6 Homo sapiens 148-152 8998126-9 1997 These fatty acids also reversed the inhibitory effect of interleukin-6 on prealbumin production. Fatty Acids 6-17 interleukin 6 Homo sapiens 57-70 35483198-0 2022 Changes in plasma total saturated fatty acids and palmitic acid are related to pro-inflammatory molecule IL-6 concentrations after nutritional intervention for one year. Fatty Acids 24-45 interleukin 6 Homo sapiens 105-109 1526345-6 1992 Other cytokines including IL-1, IL-6, and alpha-interferon increase hepatic de novo fatty acid synthesis. Fatty Acids 84-94 interleukin 6 Homo sapiens 32-36 34785106-9 2022 Furthermore, ISL promoted fatty acid metabolism via induction in the expression of PGC-1alpha-target genes PPARalpha, CPT1alpha, and ACADs, and inhibited the ROS, TNF-alpha, IL-1beta, and IL-6 expression. Fatty Acids 26-36 interleukin 6 Homo sapiens 188-192 35346671-0 2022 IL-6 promotes chemoresistance via upregulating CD36 mediated fatty acids uptake in acute myeloid leukemia. Fatty Acids 61-72 interleukin 6 Homo sapiens 0-4 35346671-8 2022 Additionally, IL-6 promoted fatty acid (FA) uptake in both AML cell lines and primary AML cells. Fatty Acids 28-38 interleukin 6 Homo sapiens 14-18 3834057-7 1985 These results suggested a possibility that the different effects of MII on the growth of HSF and MSF might be due partly to differences in the effect of MII on fatty acid synthesis between human and rodent cells. Fatty Acids 160-170 interleukin 6 Homo sapiens 89-92 35521772-10 2022 The concentrations of follicular IL-6, IL-8 and mature IL-18 were significantly higher in PCOS group and were positively correlated with the levels of fatty acids. Fatty Acids 151-162 interleukin 6 Homo sapiens 33-37