PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31427815-9 2019 Thus, intracellular saturated fatty acid-dependent palmitoylation of MYD88 by ZDHHC6 is a therapeutic target of sepsis. Fatty Acids 20-40 myeloid differentiation primary response gene 88 Mus musculus 69-74 19808018-0 2009 MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Fatty Acids 58-68 myeloid differentiation primary response gene 88 Mus musculus 0-5 34290146-4 2021 We show here that short fatty acid (FA) chain sulfatides directly activate mouse TLR4-MD-2 independent of CD14, trigger MyD88- and TRIF-dependent signaling, and stimulate tumor necrosis factor alpha (TNFalpha) and type I interferon (IFN) production in mouse macrophages. Fatty Acids 24-34 myeloid differentiation primary response gene 88 Mus musculus 120-125 12865424-4 2003 Saturated fatty acid (lauric acid)-induced NFkappaB activation was inhibited by a dominant-negative mutant of TLR4, MyD88, IRAK-1, TRAF6, or IkappaBalpha in macrophages (RAW264.7) and 293T cells transfected with TLR4 and MD2. Fatty Acids 0-20 myeloid differentiation primary response gene 88 Mus musculus 116-121 31427815-6 2019 De novo fatty acid synthesis and CD36-mediated exogenous fatty acid incorporation contributed to MYD88 palmitoylation. Fatty Acids 8-18 myeloid differentiation primary response gene 88 Mus musculus 97-102 31427815-6 2019 De novo fatty acid synthesis and CD36-mediated exogenous fatty acid incorporation contributed to MYD88 palmitoylation. Fatty Acids 57-67 myeloid differentiation primary response gene 88 Mus musculus 97-102