PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12440973-8 2002 Activation of AMPK by cellular stress or exercise therefore switches on fatty acid oxidation (via phosphorylation of ACC-2) while switching off fatty acid synthesis (via phosphorylation of ACC-1). Fatty Acids 72-82 acetyl-CoA carboxylase beta Homo sapiens 117-122 14627750-12 2003 We hypothesize that reduced amount of malonyl-CoA, consequent to reduced ACC2 mRNA, enhancing fatty acid oxidation, causes lowering of the intramyocitic triglyceride depot. Fatty Acids 94-104 acetyl-CoA carboxylase beta Homo sapiens 73-77 12856127-8 2003 CONCLUSIONS/INTERPRETATION: Lifestyle changes leading to an improved glycaemic control and reduced adiposity, resulted in a down-regulation of ACC-2 and UCP2 expression and in an increase in HAD protein content, reflecting a better capacity to utilise fatty acids. Fatty Acids 252-263 acetyl-CoA carboxylase beta Homo sapiens 143-148 12642900-3 2003 ACCbeta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyl-CoA transferase-1 (CPT-1), which is a rate-limiting enzyme of fatty acid oxidation in mitochondria. Fatty Acids 30-40 acetyl-CoA carboxylase beta Homo sapiens 0-7 12642900-3 2003 ACCbeta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine palmitoyl-CoA transferase-1 (CPT-1), which is a rate-limiting enzyme of fatty acid oxidation in mitochondria. Fatty Acids 183-193 acetyl-CoA carboxylase beta Homo sapiens 0-7 12440972-1 2002 Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. Fatty Acids 72-82 acetyl-CoA carboxylase beta Homo sapiens 129-136 12440972-1 2002 Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. Fatty Acids 190-200 acetyl-CoA carboxylase beta Homo sapiens 129-136 10393092-2 1999 ACC-beta is the predominant isoform expressed in heart and skeletal muscles, in which a major role of malonyl-CoA is probably to regulate fatty acid beta-oxidation. Fatty Acids 138-148 acetyl-CoA carboxylase beta Homo sapiens 0-8 12440972-1 2002 Acetyl-CoA carboxylase (ACC) plays a critical role in the regulation of fatty acid metabolism and its two isoforms, ACCalpha and ACCbeta, appear to have distinct functions in the control of fatty acid synthesis and fatty acid oxidation, respectively. Fatty Acids 190-200 acetyl-CoA carboxylase beta Homo sapiens 129-136 10677481-8 2000 The association of ACC2 with the mitochondria is consistent with the hypothesis that ACC2 is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Fatty Acids 137-147 acetyl-CoA carboxylase beta Homo sapiens 19-23 10677481-8 2000 The association of ACC2 with the mitochondria is consistent with the hypothesis that ACC2 is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Fatty Acids 137-147 acetyl-CoA carboxylase beta Homo sapiens 85-89 9703953-4 1998 The effect of ACC-alpha N-terminus overexpression was specific to the fatty acid synthesis rate resulting in an 80% induction, whereas overexpression of the ACC-beta N-terminus increased fatty acid oxidation rate 50% without affecting the fatty acid synthesis rate. Fatty Acids 187-197 acetyl-CoA carboxylase beta Homo sapiens 157-165 9703953-4 1998 The effect of ACC-alpha N-terminus overexpression was specific to the fatty acid synthesis rate resulting in an 80% induction, whereas overexpression of the ACC-beta N-terminus increased fatty acid oxidation rate 50% without affecting the fatty acid synthesis rate. Fatty Acids 187-197 acetyl-CoA carboxylase beta Homo sapiens 157-165 34939260-3 2022 ACACB regulates fatty-acid oxidation. Fatty Acids 16-26 acetyl-CoA carboxylase beta Homo sapiens 0-5 8876158-3 1996 In these tissues, ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Fatty Acids 64-74 acetyl-CoA carboxylase beta Homo sapiens 18-26 8876158-4 1996 ACC-beta contains an amino acid sequence at the N terminus which is about 200 amino acids long and may be uniquely related to the role of ACC-beta in controlling carnitine palmitoyltransferase I activity and fatty acid oxidation by mitochondria. Fatty Acids 208-218 acetyl-CoA carboxylase beta Homo sapiens 0-8 34939260-13 2022 The ACACB gene and its role in CV risk susceptibility, via alterations in fatty acid oxidation, remains an interesting postulate and studies with larger cohort sizes and in different ethnic groups remain warranted. Fatty Acids 74-84 acetyl-CoA carboxylase beta Homo sapiens 4-9 35359351-4 2022 ACC2 localizes on the outer membrane of mitochondria and produces malonyl-CoA to regulate the activity of carnitine palmitoyltransferase 1 (CPT1) that involves in the beta-oxidation of fatty acid. Fatty Acids 185-195 acetyl-CoA carboxylase beta Homo sapiens 0-4 27920142-2 2016 They found that these tumor cells have particularly low levels of PHD3, an enzyme that normally activates ACC2 to repress fatty-acid oxidation. Fatty Acids 122-132 acetyl-CoA carboxylase beta Homo sapiens 106-110 32487689-0 2020 Snail augments fatty acid oxidation by suppression of mitochondrial ACC2 during cancer progression. Fatty Acids 15-25 acetyl-CoA carboxylase beta Homo sapiens 68-72 33957017-4 2021 Increasing evidence shows that acetyl-CoA carboxylase 2 (ACC2) plays a crucial role in the metabolism of fatty acid, but its effect in podocyte injury of DN is still unclear. Fatty Acids 105-115 acetyl-CoA carboxylase beta Homo sapiens 31-55 33957017-4 2021 Increasing evidence shows that acetyl-CoA carboxylase 2 (ACC2) plays a crucial role in the metabolism of fatty acid, but its effect in podocyte injury of DN is still unclear. Fatty Acids 105-115 acetyl-CoA carboxylase beta Homo sapiens 57-61 29899443-3 2018 Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2, which is anchored to the outer mitochondrial membrane and controls fatty acid beta-oxidation1,3. Fatty Acids 161-171 acetyl-CoA carboxylase beta Homo sapiens 88-92 29675017-4 2018 ACC1 is located in the cytosol, where it regulates de novo fatty acid synthesis (FAS), while ACC2 is associated with the outer mitochondrial membrane, regulating fatty acid oxidation (FAO). Fatty Acids 162-172 acetyl-CoA carboxylase beta Homo sapiens 93-97 24338821-3 2014 Genome-wide association studies indicate that expression of acetyl-CoA carboxylase (ACC) 2, a key enzyme of fatty acid oxidation (FAO), is associated with proteinuria in type 2 diabetes. Fatty Acids 108-118 acetyl-CoA carboxylase beta Homo sapiens 84-90 26022126-2 2015 Although acetyl-CoA carboxylase 2 (ACC2) plays a crucial role in the fatty acid metabolism, it keeps unknown whether ACC2 is associated with autophagic activity. Fatty Acids 69-79 acetyl-CoA carboxylase beta Homo sapiens 35-39 26156967-10 2015 Fatty acid oxidation was also maintained in muscles from ACC2-KI mice contracted ex vivo. Fatty Acids 0-10 acetyl-CoA carboxylase beta Homo sapiens 57-61 26367121-3 2015 It has been previously established in various tissues that acetyl CoA carboxylase 2 (ACC2) regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria. Fatty Acids 101-111 acetyl-CoA carboxylase beta Homo sapiens 59-83 26367121-3 2015 It has been previously established in various tissues that acetyl CoA carboxylase 2 (ACC2) regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria. Fatty Acids 101-111 acetyl-CoA carboxylase beta Homo sapiens 85-89 23562819-10 2013 We suggest a regulatory role for miR-204-5p which was predicted to inhibit acetyl coenzyme A carboxylase beta, a key fatty acid oxidation enzyme that has been shown to play a role in regulating body fat and insulin resistance in adipose tissue. Fatty Acids 117-127 acetyl-CoA carboxylase beta Homo sapiens 75-109 24277613-1 2013 Acetyl-CoA carboxylase 2 (ACC2) is an isoform of ACC functioning as a negative regulator of fatty acid beta-oxidation. Fatty Acids 92-102 acetyl-CoA carboxylase beta Homo sapiens 0-24 24277613-1 2013 Acetyl-CoA carboxylase 2 (ACC2) is an isoform of ACC functioning as a negative regulator of fatty acid beta-oxidation. Fatty Acids 92-102 acetyl-CoA carboxylase beta Homo sapiens 26-30 23928362-6 2013 Special attention was paid to the up-regulated ACACB (acetyl-CoA carboxylase beta), a key enzyme in the fatty acid synthesis/oxidation balance. Fatty Acids 104-114 acetyl-CoA carboxylase beta Homo sapiens 47-52 23928362-6 2013 Special attention was paid to the up-regulated ACACB (acetyl-CoA carboxylase beta), a key enzyme in the fatty acid synthesis/oxidation balance. Fatty Acids 104-114 acetyl-CoA carboxylase beta Homo sapiens 54-81 22660331-9 2012 The inhibition of the acetyl-CoA carboxylases ACC1 and ACC2 by AMPK maintains NADPH levels by decreasing NADPH consumption in fatty-acid synthesis and increasing NADPH generation by means of fatty-acid oxidation. Fatty Acids 126-136 acetyl-CoA carboxylase beta Homo sapiens 55-59 23081748-2 2013 Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACbeta) gene, which is involved in fatty acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue, polymorphism with DN have not been studied earlier. Fatty Acids 102-112 acetyl-CoA carboxylase beta Homo sapiens 30-63 23081748-2 2013 Gene-gene interaction between acetyl-coenzymeA carboxylase beta (ACACbeta) gene, which is involved in fatty acid metabolism and angiotensin II receptors (AGTR1) gene, which mediates RAS proteins actions on renal tissue, polymorphism with DN have not been studied earlier. Fatty Acids 102-112 acetyl-CoA carboxylase beta Homo sapiens 65-73 22660331-9 2012 The inhibition of the acetyl-CoA carboxylases ACC1 and ACC2 by AMPK maintains NADPH levels by decreasing NADPH consumption in fatty-acid synthesis and increasing NADPH generation by means of fatty-acid oxidation. Fatty Acids 191-201 acetyl-CoA carboxylase beta Homo sapiens 55-59 21908218-1 2011 Acetyl-CoA carboxylase beta, encoded by the ACAB gene, plays an important role in the oxidation of fatty acids. Fatty Acids 99-110 acetyl-CoA carboxylase beta Homo sapiens 0-27 21184748-1 2011 Acetyl CoA carboxylase (ACC1 and ACC2) generates malonyl CoA, a substrate for de novo lipogenesis (DNL) and an inhibitor of mitochondrial fatty acid beta-oxidation (FAO). Fatty Acids 138-148 acetyl-CoA carboxylase beta Homo sapiens 33-37 19190759-1 2009 Acetyl-CoA carboxylases ACC1 and ACC2 catalyze the carboxylation of acetyl-CoA to malonyl-CoA, regulating fatty-acid synthesis and oxidation, and are potential targets for treatment of metabolic syndrome. Fatty Acids 106-116 acetyl-CoA carboxylase beta Homo sapiens 33-37 21887335-1 2011 BACKGROUND: Acetyl Coenzyme A carboxylase beta (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Fatty Acids 123-133 acetyl-CoA carboxylase beta Homo sapiens 147-152 21051750-5 2010 The ACACB gene (also called ACC2 or acetyl-CoA carboxylase 2) plays a critical role in intracellular fatty acid (FA) oxidation. Fatty Acids 101-111 acetyl-CoA carboxylase beta Homo sapiens 4-9 21051750-5 2010 The ACACB gene (also called ACC2 or acetyl-CoA carboxylase 2) plays a critical role in intracellular fatty acid (FA) oxidation. Fatty Acids 101-111 acetyl-CoA carboxylase beta Homo sapiens 28-32 20602615-7 2010 The acetyl coenzyme A carboxylase beta enzyme synthesizes malonyl coenzyme A, an essential substrate for hepatic fatty acid synthesis and an inhibitor of fatty acid oxidation. Fatty Acids 113-123 acetyl-CoA carboxylase beta Homo sapiens 4-38 19047759-2 2009 Acetyl-CoA carboxylases 1 and 2 (ACC1 and ACC2) catalyze the synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid oxidation. Fatty Acids 105-115 acetyl-CoA carboxylase beta Homo sapiens 42-46 19047759-2 2009 Acetyl-CoA carboxylases 1 and 2 (ACC1 and ACC2) catalyze the synthesis of malonyl-CoA, the substrate for fatty acid synthesis and the regulator of fatty acid oxidation. Fatty Acids 147-157 acetyl-CoA carboxylase beta Homo sapiens 42-46 19047759-5 2009 In this review we discuss the role of fatty acid metabolism and its key players, ACC1 and ACC2, in animal evolution and physiology, as related to health and disease. Fatty Acids 38-48 acetyl-CoA carboxylase beta Homo sapiens 90-94 21051750-5 2010 The ACACB gene (also called ACC2 or acetyl-CoA carboxylase 2) plays a critical role in intracellular fatty acid (FA) oxidation. Fatty Acids 101-111 acetyl-CoA carboxylase beta Homo sapiens 36-60 20799892-1 2010 The acetyl-CoA carboxylase isoform ACC2 expressed in the liver generates malonyl-CoA, which primarily regulates fatty acid oxidation through inhibition of the mitochondrial carrier carnitine palmitoyl-CoA transferase-I. Fatty Acids 112-122 acetyl-CoA carboxylase beta Homo sapiens 35-39 20855566-1 2010 Acetyl-CoA carboxylase beta (ACC2) plays a key role in fatty acid synthesis and oxidation pathways. Fatty Acids 55-65 acetyl-CoA carboxylase beta Homo sapiens 29-33 19190759-2 2009 Expression of ACC1 in rodent lipogenic tissues and ACC2 in rodent oxidative tissues, coupled with the predicted localization of ACC2 to the mitochondrial membrane, have suggested separate functional roles for ACC1 in lipogenesis and ACC2 in fatty acid oxidation. Fatty Acids 241-251 acetyl-CoA carboxylase beta Homo sapiens 128-132 19190759-2 2009 Expression of ACC1 in rodent lipogenic tissues and ACC2 in rodent oxidative tissues, coupled with the predicted localization of ACC2 to the mitochondrial membrane, have suggested separate functional roles for ACC1 in lipogenesis and ACC2 in fatty acid oxidation. Fatty Acids 241-251 acetyl-CoA carboxylase beta Homo sapiens 128-132 16142397-5 2005 In NAFLD, expression of ACC1 and ACC2, but not FAS was increased, indicating that de novo fatty acid synthesis is enhanced in NAFLD. Fatty Acids 90-100 acetyl-CoA carboxylase beta Homo sapiens 33-37 17477831-1 2007 Acetyl-coenzyme A carboxylase (ACC) enzymes exist as two isoforms, ACC1 and ACC2, which play critical roles in fatty acid biosynthesis and oxidation. Fatty Acids 111-121 acetyl-CoA carboxylase beta Homo sapiens 76-80 17477831-4 2007 The mitochondrial ACC2 is primarily expressed in heart and skeletal muscle, where it is involved in the regulation of fatty acid oxidation. Fatty Acids 118-128 acetyl-CoA carboxylase beta Homo sapiens 18-22 16854592-1 2007 Acetyl coenzyme A (acetyl-CoA) carboxylase isozyme 1 (ACC1) and acetyl-CoA carboxylase isozyme 2 (ACC2) are critical for de novo fatty acid synthesis and for the regulation of beta-oxidation. Fatty Acids 129-139 acetyl-CoA carboxylase beta Homo sapiens 98-102 18826455-4 2008 Furthermore, it is known that the enzyme acetyl-CoA carboxylase2 (ACC2) suppresses the oxidation of fatty acids by inhibiting the entry of fatty acids into mitochondria. Fatty Acids 100-111 acetyl-CoA carboxylase beta Homo sapiens 41-64 18826455-4 2008 Furthermore, it is known that the enzyme acetyl-CoA carboxylase2 (ACC2) suppresses the oxidation of fatty acids by inhibiting the entry of fatty acids into mitochondria. Fatty Acids 100-111 acetyl-CoA carboxylase beta Homo sapiens 66-70 18826455-4 2008 Furthermore, it is known that the enzyme acetyl-CoA carboxylase2 (ACC2) suppresses the oxidation of fatty acids by inhibiting the entry of fatty acids into mitochondria. Fatty Acids 139-150 acetyl-CoA carboxylase beta Homo sapiens 41-64 18826455-4 2008 Furthermore, it is known that the enzyme acetyl-CoA carboxylase2 (ACC2) suppresses the oxidation of fatty acids by inhibiting the entry of fatty acids into mitochondria. Fatty Acids 139-150 acetyl-CoA carboxylase beta Homo sapiens 66-70 18452391-6 2008 Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA. Fatty Acids 91-101 acetyl-CoA carboxylase beta Homo sapiens 134-138 18452391-6 2008 Using this detection method for CoA, we measured the activity of sequential enzymes in the fatty acid synthesis pathway to develop an ACC2/FAS-coupled assay where ACC2 produces malonyl-CoA from acetyl-CoA. Fatty Acids 91-101 acetyl-CoA carboxylase beta Homo sapiens 163-167 15590647-1 2005 Acetyl-CoA carboxylase beta (ACCbeta) is a critical enzyme in the regulation of fatty acid oxidation and is dominantly expressed in the skeletal muscle, heart, and liver. Fatty Acids 80-90 acetyl-CoA carboxylase beta Homo sapiens 0-27 15590647-1 2005 Acetyl-CoA carboxylase beta (ACCbeta) is a critical enzyme in the regulation of fatty acid oxidation and is dominantly expressed in the skeletal muscle, heart, and liver. Fatty Acids 80-90 acetyl-CoA carboxylase beta Homo sapiens 29-36