PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26971994-0 2016 Saturated Fatty Acids Engage an IRE1alpha-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells. Fatty Acids 0-21 NLR family pyrin domain containing 3 Homo sapiens 76-81 27077881-3 2016 In the setting of excess nutrients, particularly dietary saturated fatty acids (SFAs), activated macrophages develop lysosome dysfunction, which triggers activation of the NLRP3 inflammasome and cell death. Fatty Acids 57-78 NLR family pyrin domain containing 3 Homo sapiens 172-177 21478880-0 2011 Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Fatty Acids 0-10 NLR family pyrin domain containing 3 Homo sapiens 19-24 25175736-5 2014 SFAs (saturated fatty acids), unlike UFAs (unsaturated fatty acids), have recently been proposed as triggers of the NLRP3 inflammasome, a molecular platform mediating the processing of IL-1beta in response to infection and stress conditions. Fatty Acids 6-27 NLR family pyrin domain containing 3 Homo sapiens 116-121 24006511-3 2013 Here we reported opposite effects of saturated fatty acids (SFAs) compared with unsaturated fatty acids (UFAs) on NLRP3 inflammasome in human monocytes/macrophages. Fatty Acids 37-58 NLR family pyrin domain containing 3 Homo sapiens 114-119 8668150-12 1996 Since the J site also confers responsiveness of the apo A-II gene to fibrates and fatty acids via the activation of peroxisome proliferator-activated receptor-RXR heterodimers, this site can be considered a plurimetabolic response element. Fatty Acids 82-93 NLR family pyrin domain containing 3 Homo sapiens 56-60 34145545-4 2021 increased plasma glucose, fatty acids, and beta-amyloid are augmented during obesity and activate NLRP3 inflammasome expression. Fatty Acids 26-37 NLR family pyrin domain containing 3 Homo sapiens 98-103 32975056-0 2021 Nlrp3, Csf3, and Edn1 in Macrophage Response to Saturated Fatty Acids and Modified Low-Density Lipoprotein. Fatty Acids 48-69 NLR family pyrin domain containing 3 Homo sapiens 0-5 35271969-1 2022 BACKGROUND: Chronic low-grade systemic inflammation (SI), including activation of the NLRP3 inflammasome, is a feature of obesity, associated with increased circulating saturated fatty acids, such as palmitic acid (PA), and bacterial endotoxin lipopolysaccharide (LPS). Fatty Acids 169-190 NLR family pyrin domain containing 3 Homo sapiens 86-91 34058186-0 2021 Pharmacological inhibition of fatty acid oxidation reduces atherosclerosis progression by suppression of macrophage NLRP3 inflammasome activation. Fatty Acids 30-40 NLR family pyrin domain containing 3 Homo sapiens 116-121 34058186-3 2021 Fatty acid oxidation (FAO) was previously demonstrated to interact with the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) pathway which is required for mature IL-1beta secretion. Fatty Acids 0-10 NLR family pyrin domain containing 3 Homo sapiens 76-124 34058186-3 2021 Fatty acid oxidation (FAO) was previously demonstrated to interact with the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) pathway which is required for mature IL-1beta secretion. Fatty Acids 0-10 NLR family pyrin domain containing 3 Homo sapiens 126-131 30704542-3 2019 Our work demonstrated that different fatty acids differentially modulate metabolic-inflammation, initially focusing on Nod-like receptor family, pyrin domain-containing three protein (NLRP3) inflammasome mediated IL-1beta biology and insulin signalling. Fatty Acids 37-48 NLR family pyrin domain containing 3 Homo sapiens 184-189 31432628-2 2019 The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1beta inflammation and IR. Fatty Acids 104-125 NLR family pyrin domain containing 3 Homo sapiens 4-47 31432628-2 2019 The nod-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a metabolic sensor activated by saturated fatty acids (SFA) initiating IL-1beta inflammation and IR. Fatty Acids 104-125 NLR family pyrin domain containing 3 Homo sapiens 49-54 31432628-3 2019 Interactions between SFA intake and NLRP3-related genetic variants may alter T2D risk factors. Fatty Acids 21-24 NLR family pyrin domain containing 3 Homo sapiens 36-41 29857009-9 2019 In Study 2 the saturated fatty acid meal led to increases in sputum neutrophil percentages and sputum cell gene expression of Toll-like receptor 4 (TLR4) and NLRP3 at 4 hours in nonobese asthmatic patients. Fatty Acids 15-35 NLR family pyrin domain containing 3 Homo sapiens 158-163 30923255-0 2019 Saturated fatty acid-crystals activate NLRP3 inflammasome. Fatty Acids 0-20 NLR family pyrin domain containing 3 Homo sapiens 39-44 30953761-0 2019 Saturated fatty acids induce NLRP3 activation in human macrophages through K+ efflux resulting from phospholipid saturation and Na, K-ATPase disruption. Fatty Acids 0-21 NLR family pyrin domain containing 3 Homo sapiens 29-34 30953761-2 2019 Saturated fatty acids (SFAs) are sterile triggers able to induce the assembly of the NLRP3 inflammasome in macrophages, leading to IL-1beta secretion while unsaturated ones (UFAs) prevent SFAs-mediated NLRP3 activation. Fatty Acids 0-21 NLR family pyrin domain containing 3 Homo sapiens 85-90 30953761-2 2019 Saturated fatty acids (SFAs) are sterile triggers able to induce the assembly of the NLRP3 inflammasome in macrophages, leading to IL-1beta secretion while unsaturated ones (UFAs) prevent SFAs-mediated NLRP3 activation. Fatty Acids 0-21 NLR family pyrin domain containing 3 Homo sapiens 202-207 30953761-9 2019 This SFA-induced membrane remodeling promotes a disruption of the plasma membrane Na, K-ATPase, instigating a K+ efflux essential and sufficient for NLRP3 activation. Fatty Acids 5-8 NLR family pyrin domain containing 3 Homo sapiens 149-154 29258239-1 2017 Saturated fatty acids were proposed to activate the NLRP3 inflammasome, a molecular platform that mediates the processing of interleukin (IL)-1beta and IL-18. Fatty Acids 0-21 NLR family pyrin domain containing 3 Homo sapiens 52-57 30305631-3 2018 Here we show, using CTLs from patients with CD46 deficiency or with constitutively-active NLRP3, that CD46 delivers co-stimulatory signals for optimal CTL activity by augmenting nutrient-influx and fatty acid synthesis. Fatty Acids 198-208 NLR family pyrin domain containing 3 Homo sapiens 90-95 28826373-5 2017 The NLRP3 inflammasome can be influenced by various metabolites, including fatty acids. Fatty Acids 75-86 NLR family pyrin domain containing 3 Homo sapiens 4-9 28826373-7 2017 Therefore, the NLRP3 inflammasome and associated metabolic inflammation have key roles in the relationships among fatty acids, metabolites, and metabolic disease. Fatty Acids 114-125 NLR family pyrin domain containing 3 Homo sapiens 15-20