PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20808948-6	2010	The selective Pim-1 kinase inhibitor quercetagetin was shown to be the most potent synapsin I binder (IC50 = 0.15 microM), in agreement with the predicted binding site similarities between synapsin I and various protein kinases.	quercetagetin	37-50	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-19	
21187157-4	2011	Pharmacological inhibition of the Pim-1 kinase activity with quercetagetin, a highly selective Pim-1 inhibitor, prevented R1881-mediated increase in Bad phosphorylation and restored cell sensitivity to LY294002-induced apoptosis despite the increase in Bcl-xL expression.	quercetagetin	61-74	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39	
21187157-4	2011	Pharmacological inhibition of the Pim-1 kinase activity with quercetagetin, a highly selective Pim-1 inhibitor, prevented R1881-mediated increase in Bad phosphorylation and restored cell sensitivity to LY294002-induced apoptosis despite the increase in Bcl-xL expression.	quercetagetin	61-74	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	95-100	
30809095-10	2019	Interestingly, Pim1 inhibitor quercetagetin significantly inhibited the proliferation of CNE1-LMP1-OV cells.	quercetagetin	30-43	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	15-19	
17218638-5	2007	Resolution of the crystal structure of PIM1 in complex with quercetagetin or two other flavonoids revealed a spectrum of binding poses and hydrogen-bonding patterns in spite of strong similarity of the ligands.	quercetagetin	60-73	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	39-43	
17218638-6	2007	Quercetagetin was a highly selective inhibitor of PIM1 compared with PIM2 and seven other serine-threonine kinases.	quercetagetin	0-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	50-54	
17218638-7	2007	Quercetagetin was able to inhibit PIM1 activity in intact RWPE2 prostate cancer cells in a dose-dependent manner (ED(50), 5.5 micromol/L).	quercetagetin	0-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-38	
17218638-8	2007	RWPE2 cells treated with quercetagetin showed pronounced growth inhibition at inhibitor concentrations that blocked PIM1 kinase activity.	quercetagetin	25-38	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	116-120	
17218638-9	2007	Furthermore, the ability of quercetagetin to inhibit the growth of other prostate epithelial cell lines varied in proportion to their levels of PIM1 protein.	quercetagetin	28-41	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	144-148	
17218638-10	2007	Quercetagetin can function as a moderately potent and selective, cell-permeable inhibitor of the pim-1 kinase, and may be useful for proof-of-concept studies to support the development of clinically useful PIM1 inhibitors.	quercetagetin	0-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	97-102	
17218638-10	2007	Quercetagetin can function as a moderately potent and selective, cell-permeable inhibitor of the pim-1 kinase, and may be useful for proof-of-concept studies to support the development of clinically useful PIM1 inhibitors.	quercetagetin	0-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	206-210