PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33476709-8 2021 Incubation of MBX-2168 alone or with dCF in Vero cells resulted in 12.8+-0.1 and 6.7+-0.7 pmol triphosphate/106 cells at 24 hours, respectively. triphosphoric acid 95-107 diencephalon/mesencephalon homeobox 1 Homo sapiens 14-17 33476709-11 2021 We conclude that dCF antagonizes the anti-viral effect of MBX-2168 by inhibiting the production of triphosphate, the active compound. triphosphoric acid 99-111 diencephalon/mesencephalon homeobox 1 Homo sapiens 58-61 31332074-8 2019 We therefore conclude that ADAL-1 is the enzyme responsible for removing the moiety from the guanine ring of MBX-2168-MP prior to conversion to a triphosphate, the active compound that inhibits the viral DNA polymerase. triphosphoric acid 146-158 diencephalon/mesencephalon homeobox 1 Homo sapiens 109-112 31968222-5 2020 Incubation of HCMV-infected cells with five times the EC50 of MBX-2168 (4.0 muM), synguanol (10.5 muM), or GCV (25 muM) resulted in a time-dependent increase in triphosphate accumulation reaching a maximum of 48.1 +- 5.5, 45.5 +- 2.5, and 42.6 +- 3.7 pmol/106 cells at 120 h, respectively. triphosphoric acid 161-173 diencephalon/mesencephalon homeobox 1 Homo sapiens 62-65 31968222-7 2020 HSV-1-infected cells incubated with five times the EC50 of MBX-2168 (33.5 muM) or ACV (5.0 muM) demonstrated a time-dependent increase in triphosphate levels reaching a maximum of 12.3 +- 1.5 and 11.6 +- 0.7 pmol/106 cells at 24 h, respectively. triphosphoric acid 138-150 diencephalon/mesencephalon homeobox 1 Homo sapiens 59-62