PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34252545-3 2021 We demonstrated that diosgenin suppressed COX-2 in human non-small-cell lung carcinoma A549 cells via nuclear factor-kappa B (NF-kappaB) translocation and the effects were reversed by a glucocorticoid receptor antagonist, RU486. Mifepristone 222-227 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 21376132-3 2011 Human CG induction of immunoreactive COX-2 in the granulosa layer of mature Graafian follicles at hCG8h was reduced by RU486 treatment at hCG0h and trilostane treatment at hCG4h. Mifepristone 119-124 mitochondrially encoded cytochrome c oxidase II Homo sapiens 37-42 10508225-11 1999 After treatment with mifepristone, expression of COX-1 in glandular epithelium and COX-2 in luminal epithelium significantly decreased whilst the immunostaining for COX-2 in the perivascular cells remained strong. Mifepristone 21-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 83-88 10508225-11 1999 After treatment with mifepristone, expression of COX-1 in glandular epithelium and COX-2 in luminal epithelium significantly decreased whilst the immunostaining for COX-2 in the perivascular cells remained strong. Mifepristone 21-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 165-170 10508225-12 1999 This study shows the expression of both COX-1 and COX-2 during the implantation period and also indicates that treatment with mifepristone in early luteal phase impairs glandular epithelial function and endometrial receptivity. Mifepristone 126-138 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 9822711-7 1998 This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486. Mifepristone 174-181 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 25319133-8 2014 Of note, the inhibitory effects of PDN on the IL-1beta-induced expression of COX-2 and the activation of ERK-1/2 and JNK-1 in the HEI-OC1 cells were significantly diminished by RU486, a glucocorticoid receptor (GR) antagonist, suggesting that PDN exerts its inhibitory effects through GR. Mifepristone 177-182 mitochondrially encoded cytochrome c oxidase II Homo sapiens 77-82 24172143-6 2014 KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486. Mifepristone 201-206 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-50