PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35619328-2	2022	Here, it is demonstrated that the WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the protein kinase RNA-like ER kinase (PERK) and inositol-required enzyme 1alpha (IRE1alpha) branches of the unfolded protein response (UPR) in TP53 mutant (mtTP53) ovarian cancer models.	Inositol	157-165	tumor protein p53	Homo sapiens	252-256	
31936679-11	2020	To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2.	Inositol	136-144	tumor protein p53	Homo sapiens	305-308	
29130967-4	2017	RESULTS: Mutant p53 cells exhibited increased expression of the C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and inositol-requiring enzyme-1alpha (IRE1alpha).	Inositol	139-147	tumor protein p53	Homo sapiens	16-19	
27035231-0	2016	Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway.	Inositol	14-26	tumor protein p53	Homo sapiens	43-46	
27035231-4	2016	Through a microarray screening, we found that five genes related with myo-inositol metabolism were induced by p53.	Inositol	70-82	tumor protein p53	Homo sapiens	110-113	
27035231-5	2016	DNA damage enhanced intracellular myo-inositol content in HCT116 p53+/+ cells, but not in HCT116 p53-/- cells.	Inositol	34-46	tumor protein p53	Homo sapiens	65-68	
27035231-6	2016	We also indicated that inositol 3-phosphate synthase (ISYNA1) which encodes an enzyme essential for myo-inositol biosynthesis as a direct target of p53.	Inositol	100-112	tumor protein p53	Homo sapiens	148-151	
27035231-11	2016	Our findings revealed a novel role of p53 in myo-inositol biosynthesis which could be a potential therapeutic target.	Inositol	45-57	tumor protein p53	Homo sapiens	38-41