PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22232265-1	2012	A malfunction in the yeast HAC1 causes the unfolding-protein response in the endoplasmic reticulum, resulting in stress-sensitive and inositol auxotrophic phenotypes.	Inositol	134-142	transcription factor HAC1	Saccharomyces cerevisiae S288C	27-31	
22232265-3	2012	The introduction of the truncated human CCT epsilon subunit into yeast cells of which hac1 was disrupted clearly suppressed not only its inositol auxotrophic phenotype but also its stress-sensitive phenotype.	Inositol	137-145	transcription factor HAC1	Saccharomyces cerevisiae S288C	86-90	
9409765-1	1997	We previously reported that the Saccharomyces cerevisiae ire15 mutation results in an inositol-auxotrophic phenotype, and that human cDNAs can suppress the ire15 mutation (Nikawa, J., 1994.	Inositol	86-94	transcription factor HAC1	Saccharomyces cerevisiae S288C	57-62	
16041130-2	2005	IRE1- and HAC1-disruptants require high concentrations of inositol for its normal growth.	Inositol	58-66	transcription factor HAC1	Saccharomyces cerevisiae S288C	10-14	
16041130-5	2005	However, the growth defect of the hac1-alg10 double disrupted was partially, but significantly, suppressed by the addition of inositol to the medium.	Inositol	126-134	transcription factor HAC1	Saccharomyces cerevisiae S288C	34-38	
11489850-10	2001	Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium.	Inositol	92-100	transcription factor HAC1	Saccharomyces cerevisiae S288C	63-67	
11489850-10	2001	Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium.	Inositol	188-196	transcription factor HAC1	Saccharomyces cerevisiae S288C	63-67	
9409765-8	1997	All human cDNAs and yeast multicopy suppressors, which had been isolated as suppressors for the ire15 mutation, were able to suppress the inositol-auxotrophic phenotype but not the defect in KAR2 induction of the hac1-disrupted strain.	Inositol	138-146	transcription factor HAC1	Saccharomyces cerevisiae S288C	96-101	
8932376-5	1996	ire2/hac1-disrupted yeast cells showed not only the inositol auxotrophic phenotype but also the tunicamycin sensitivity, and failed to induce the expression of KAR2.	Inositol	52-60	transcription factor HAC1	Saccharomyces cerevisiae S288C	5-9	
9077435-7	1996	Cells lacking Ern4p are unable to induce transcription of any of the five target genes tested and exhibit sensitivity to ER stress and inositol requirement for growth.	Inositol	135-143	transcription factor HAC1	Saccharomyces cerevisiae S288C	14-19	
8675017-1	1996	The Saccharomyces cerevisiae ire15 mutant has a defect in the expression of the IN01 gene, showing an inositol auxotrophic phenotype.	Inositol	102-110	transcription factor HAC1	Saccharomyces cerevisiae S288C	29-34	
8537323-1	1995	Saccharomyces cerevisiae ire15 mutant has a defect in the expression of INO1, showing the inositol auxotrophic phenotype [Nikawa, J.	Inositol	90-98	transcription factor HAC1	Saccharomyces cerevisiae S288C	25-30	
27256815-2	2016	The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, is the most ancient branch of the UPR.	Inositol	4-12	transcription factor HAC1	Saccharomyces cerevisiae S288C	115-119	
8932376-6	1996	These results clearly indicate that the IRE2/HAC1 gene product plays a critical role in the induction of KAR2 expression and in the inositol prototrophy mediated by IRE1.	Inositol	132-140	transcription factor HAC1	Saccharomyces cerevisiae S288C	45-49