PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22876243-4	2012	One such target is the SH2 domain-containing inositol-5-phosphatase-1 (SHIP-1) which de-phosphorylates PI(3,4,5)P(3) at the D5 position of the inositol ring to create PI(3,4)P(2).	Inositol	45-53	inositol polyphosphate-5-phosphatase D	Homo sapiens	71-77	
24091101-2	2014	The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2.	Inositol	26-34	inositol polyphosphate-5-phosphatase D	Homo sapiens	50-55	
16000869-6	2005	Taken together, these results suggest that SHIP1 may function as an adaptor protein which can potentiate EGF-induced PLC-gamma1 activation without regards to its inositol 5"-phosphatase activity.	Inositol	162-170	inositol polyphosphate-5-phosphatase D	Homo sapiens	43-48	
19839650-1	2009	SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,4-diphosphate.	Inositol	22-30	inositol polyphosphate-5-phosphatase D	Homo sapiens	49-54	
19494109-2	2009	The SH2 domain-containing inositol 5" phosphatase, SHIP1, regulates hematopoietic cell function by opposing the action of phos pha tidyl ino si tol 3-kinase and reducing the levels of PtdIns 3,4,5-P(3).	Inositol	26-34	inositol polyphosphate-5-phosphatase D	Homo sapiens	51-56	
16406061-0	2006	The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation.	Inositol	26-34	inositol polyphosphate-5-phosphatase D	Homo sapiens	49-54	
20810657-0	2010	A key role for the phosphorylation of Ser440 by the cyclic AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5"-phosphatase (SHIP1).	Inositol	155-163	inositol polyphosphate-5-phosphatase D	Homo sapiens	180-185	
18791164-4	2009	This cross-regulation requires BCR and FcgammaRIIB coligation, and optimal action relies on the Src-homology-2 (SH2)-containing inositol 5 phosphase-1 (SHIP1).	Inositol	128-136	inositol polyphosphate-5-phosphatase D	Homo sapiens	152-157	
12529653-4	2003	The results of an in vitro inositol 5"-phosphatase assay revealed that the mutation reduced catalytic activity of SHIP.	Inositol	27-35	inositol polyphosphate-5-phosphatase D	Homo sapiens	114-118	
12217398-4	2002	When coaggregated with FcepsilonRI, the FcgammaRIIB ITIM is tyrosyl-phosphorylated by the src family protein tyrosine kinase lyn, and recruits the SH2 domain-containing inositol 5-phosphatase SHIP that accounts for inhibition of cell activation.	Inositol	169-177	inositol polyphosphate-5-phosphatase D	Homo sapiens	192-196	
10224142-8	1999	Three of these substrates were identified as the tyrosine kinase pp72(syk), the phospholipase Cgamma2, and the inositol 5-phosphatase SHIP.	Inositol	111-119	inositol polyphosphate-5-phosphatase D	Homo sapiens	134-138	
9013643-5	1997	Co-cross-linking sIg and the FcR enhanced the phosphorylation of the FcR, the adapter protein, Shc, and the inositol 5"-phosphatase Ship.	Inositol	108-116	inositol polyphosphate-5-phosphatase D	Homo sapiens	132-136	
8805618-4	1996	Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism.	Inositol	252-260	inositol polyphosphate-5-phosphatase D	Homo sapiens	166-170	
10395202-1	1998	Previous studies by our lab and others established that co-crosslinking sIg and IgG receptor FcgammaRIIb in B cells in a feedback suppression model (negative signaling) promoted tyrosine phosphorylation of the inositol 5-phosphatase SHIP and its interaction with Shc and that these events were associated with inhibition of the Ras pathway.	Inositol	210-218	inositol polyphosphate-5-phosphatase D	Homo sapiens	233-237