PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8977400-7 1997 Treatment with the GTPCH inhibitor 2,4-diamino-6-hydroxypyrimidine prevented IL-1 beta-induced NOS activity in untreated or FSH-stimulated cells, and this inhibition was completely reversed by sepiapterin, a substrate for BH4 biosynthesis, via an alternative pterin salvage pathway present in many cell types. Pterins 198-204 interleukin 1 beta Homo sapiens 77-86 8662883-5 1996 In contrast, sepiapterin, which provides BH4 through the pterin salvage pathway, strongly potentiated IL-1beta/TNF-alpha-induced iNOS expression and abrogated the inhibitory effect of DAHP. Pterins 18-24 interleukin 1 beta Homo sapiens 102-110