PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15356430-8	2004	Because several inflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting the metabolism of several endogenous lipophilic substances such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances, their irregularities in the body may eventually lead to the flare of latent diseases in some predisposed subjects.	Thromboxanes	345-357	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	78-94	
6457649-7	1981	These data provide further support for a role of cytochrome P-450 in thromboxane synthesis and platelet aggregation.	Thromboxanes	69-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	49-65	
15543094-7	2004	These proinflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting metabolism of several endogenous lipophilic substances, such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances.	Thromboxanes	335-347	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	71-87	
1327375-2	1992	The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM).	Thromboxanes	188-199	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	4-20