PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15543094-7 2004 These proinflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting metabolism of several endogenous lipophilic substances, such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances. Thromboxanes 335-347 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 15356430-8 2004 Because several inflammatory cytokines down-regulate gene expression of major cytochrome P-450 and/or other enzymes with the specific effects on mRNA levels, protein expression, and enzyme activity, thus affecting the metabolism of several endogenous lipophilic substances such as steroids, lipid-soluble vitamins, prostaglandins, leukotrienes, thromboxanes, and exogenous substances, their irregularities in the body may eventually lead to the flare of latent diseases in some predisposed subjects. Thromboxanes 345-357 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 78-94 1327375-2 1992 The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM). Thromboxanes 188-199 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 6457649-7 1981 These data provide further support for a role of cytochrome P-450 in thromboxane synthesis and platelet aggregation. Thromboxanes 69-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 49-65