PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23723870-3 2013 The 1,4-di-hydro-pyridine (1,4-DHP) ring adopts a slightly puckered boat-like conformation. 1,4-dihydropyridine 4-25 dihydropyrimidinase Homo sapiens 31-34 22709591-3 2012 Positively charged amphiphilic 1,4-dihydropyridine (1,4-DHP) derivatives were earlier proposed as a promising tool for the delivery of DNA into target cells in vitro and in vivo. 1,4-dihydropyridine 31-50 dihydropyrimidinase Homo sapiens 56-59 23476440-1 2013 In the title salt, C37H51N2O10(+) Br(-), the 1,4-dihydro-pyridine (1,4-DHP) ring adopts a slighly puckered boat conformation. 1,4-dihydropyridine 45-65 dihydropyrimidinase Homo sapiens 71-74 19056096-4 2009 The DHP made of coniferaldehyde had poorer solubility properties than the other DHPs, and through contact angle of water measurement on spin-coated surfaces of the polymeric materials, the DHPs made of coniferaldehyde and carboxylic ferulic acid exhibited higher hydrophobicity than the coniferyl alcohol DHP. 1,4-dihydropyridine 189-193 dihydropyrimidinase Homo sapiens 4-7 16202640-1 2005 Compounds of the 1,4-dihydropyridine (1,4-DHP) series have been shown to reduce spontaneous, alkylation- and radiation-induced mutation rates in animal test systems. 1,4-dihydropyridine 17-36 dihydropyrimidinase Homo sapiens 42-45 17011717-4 2007 Indeed, the data from dihydropyridine-based calcium antagonist (DHP) trails are consistent in that they could not protect against new-onset heart failure or progression of renal disease in patients with left-ventricular systolic dysfunction or overt proteinuria, respectively. 1,4-dihydropyridine 22-37 dihydropyrimidinase Homo sapiens 64-67 16425978-1 2005 We have previously shown that azelnidipine, a long-acting dihydropyridine-based calcium antagonist (DHP), inhibited tumor necrosis factor-alpha-induced endothelial cell (EC) activation through its antioxidative properties. 1,4-dihydropyridine 58-73 dihydropyrimidinase Homo sapiens 100-103 10769189-1 2000 Sensitivity to 1,4-dihydropyridines (DHPs) can be transferred from L-type (alpha1C) to non-L-type (alpha1A) Ca(2+) channel alpha1 subunits by the mutation of nine pore-associated non-conserved amino acid residues, yielding mutant alpha1A(DHP). 1,4-dihydropyridine 15-35 dihydropyrimidinase Homo sapiens 37-40 15893134-8 2005 In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long-acting dihydropyridine-based calcium antagonist (DHP), inhibited TNF-alpha-induced activator protein-1 activation and interleukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. 1,4-dihydropyridine 165-180 dihydropyrimidinase Homo sapiens 207-210 15553218-1 2004 PURPOSE: To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. 1,4-dihydropyridine 55-70 dihydropyrimidinase Homo sapiens 77-80 12574487-3 2003 Expression of the Ca(V)1.3alpha(1) subunit in human embryonic kidney cells (HEK 293) produced a dihydropyridine (DHP)-sensitive Ca(2+) current (peak current density -2.0 +/- 0.2 pA/pF; n = 11). 1,4-dihydropyridine 96-111 dihydropyrimidinase Homo sapiens 113-116 12036722-1 2002 Double-charged 1,4-dihydropyridine (1,4-DHP) amphiphiles have been shown to condense DNA and efficiently transfect it into cells in vitro [Hyvonen et al., Biochim. 1,4-dihydropyridine 15-34 dihydropyrimidinase Homo sapiens 40-43 11118554-1 2000 In order to find new efficient and safe agents for gene delivery, we have designed and synthesized nine novel single- and double-charged amphiphiles on the base of 1,4-dihydropyridine (1,4-DHP) ring. 1,4-dihydropyridine 164-183 dihydropyrimidinase Homo sapiens 189-192 8363652-1 1993 The 1,4-dihydropyridine (1,4-DHP) and 1,4-dihydroindeno[1,2-b]pyridine (1,4-DHIP) derivatives were investigated as glutathione S-transferase (GT) inhibitors. 1,4-dihydropyridine 4-23 dihydropyrimidinase Homo sapiens 29-32 10234737-1 1999 In this study, the synthesis of new flavonoid derivatives, which possess a 1,4-dihydropyridine (1,4-DHP) moiety on the phenyl ring of flavone were realized. 1,4-dihydropyridine 75-94 dihydropyrimidinase Homo sapiens 100-103 8072847-2 1994 Slowly activating, dihydropyridine(DHP)-sensitive currents, associated with T-tubular DHP receptors and ion channels, could be isolated from rapidly activating, DHP-resistant currents. 1,4-dihydropyridine 19-34 dihydropyrimidinase Homo sapiens 35-38 8072847-2 1994 Slowly activating, dihydropyridine(DHP)-sensitive currents, associated with T-tubular DHP receptors and ion channels, could be isolated from rapidly activating, DHP-resistant currents. 1,4-dihydropyridine 19-34 dihydropyrimidinase Homo sapiens 86-89 8072847-2 1994 Slowly activating, dihydropyridine(DHP)-sensitive currents, associated with T-tubular DHP receptors and ion channels, could be isolated from rapidly activating, DHP-resistant currents. 1,4-dihydropyridine 19-34 dihydropyrimidinase Homo sapiens 86-89 10739116-2 2000 METHODS: In this paper we used the 1,4-dihydropyridine (1,4-DHP) MDR-reversing agent dexniguldipine (DN), and a derivative with a quaternary nitrogen which is permanently charged, N-methyl-DN, to explore the sidedness of block of [3H]-vinblastine transport by P-gp. 1,4-dihydropyridine 35-54 dihydropyrimidinase Homo sapiens 60-63 1703081-1 1990 The release of [3H]monoamines from preloaded synaptosomes from spinal cord is K(+)-dependent and can be modulated by L-type Ca2+ channel agonists such as the 1,4-dihydropyridine (1,4-DHP), Bay K 8644. 1,4-dihydropyridine 158-177 dihydropyrimidinase Homo sapiens 183-186 35228389-1 2022 We previously isolated an aminobutadiene derivative as a by-product in the synthesis of a 1,4-dihydropyridine (1,4-DHP) derivative by the reaction of methyl propiolate with excess ammonium acetate in water, and we proposed that it is an intermediate in the formation of 1,4-DHP. 1,4-dihydropyridine 90-109 dihydropyrimidinase Homo sapiens 115-118 34846145-1 2021 The annulation of N-cyclopropyl enamines to produce 1,4-dihydropyridine (1,4-DHP) derivatives is described. 1,4-dihydropyridine 52-71 dihydropyrimidinase Homo sapiens 77-80 35228389-1 2022 We previously isolated an aminobutadiene derivative as a by-product in the synthesis of a 1,4-dihydropyridine (1,4-DHP) derivative by the reaction of methyl propiolate with excess ammonium acetate in water, and we proposed that it is an intermediate in the formation of 1,4-DHP. 1,4-dihydropyridine 90-109 dihydropyrimidinase Homo sapiens 274-277 33006198-1 2021 The Hantzcsh reaction is a robust four-component reaction for the efficient generation of 1,4-dihydropyridine (1,4-DHP) derivatives. 1,4-dihydropyridine 90-109 dihydropyrimidinase Homo sapiens 115-118 33219601-8 2021 RESULTS: Multivariate results revealed inverse associations for time to PD diagnosis with exposure to the combination of the combination of angiotensin receptor II blockers (ARBs) and dihydropyridine calcium channel blockers (DHP-CCB) (HR=0.55, p< 0.01) and angiotensin converting enzyme inhibitors (ACEi) and diuretics (HR=0.60, p-value <0.01). 1,4-dihydropyridine 184-199 dihydropyrimidinase Homo sapiens 226-229 31473427-1 2019 A convenient strategy for synthesis of the various derivatives of 1,4-dihydropyridine (1,4-DHP), as one of the most important pharmaceutical compounds, is presented in this study. 1,4-dihydropyridine 66-85 dihydropyrimidinase Homo sapiens 91-94 31561891-1 2019 1,4-Dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. 1,4-dihydropyridine 0-20 dihydropyrimidinase Homo sapiens 26-29 28590004-3 2017 The enantioenriched 3,4-DHP-2-ones have easily been converted into highly functionalized (R)- and (S)-1,4-dihydropyridines (1,4-DHPs) by means of a Vilsmeier-Haack reaction. 1,4-dihydropyridine 124-132 dihydropyrimidinase Homo sapiens 24-27 31735158-2 2019 Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. 1,4-dihydropyridine 41-60 dihydropyrimidinase Homo sapiens 66-69 29928120-1 2018 Background: 1,4-Dihydropyridine (1,4-DHP) and its derivatives are well-known calcium channel blockers with antiarrhythmic and antihypertensive activities. 1,4-dihydropyridine 12-31 dihydropyrimidinase Homo sapiens 37-40 29713564-1 2018 Background: 1,4-dihydropyridines (1,4-DHP) possesses important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. 1,4-dihydropyridine 12-32 dihydropyrimidinase Homo sapiens 38-41