PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33971831-2	2021	Dihydropyridine calcium-channel blockers (CCB) are the most popular class of antihypertensive drugs used in clinical settings and can be metabolized by cytochrome P450 isoenzyme 3A4 (CYP3A4).	1,4-dihydropyridine	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-181	
33971831-2	2021	Dihydropyridine calcium-channel blockers (CCB) are the most popular class of antihypertensive drugs used in clinical settings and can be metabolized by cytochrome P450 isoenzyme 3A4 (CYP3A4).	1,4-dihydropyridine	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	183-189	
28407303-2	2017	Rifampicin, an antitubercular agent, is one of the most potent inducers of hepatic and intestinal CYP3A4 thus increasing dihydropyridine metabolism.	1,4-dihydropyridine	121-136	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-104	
28645473-1	2017	Non-dihydropyridine calcium channel blockers (non-DHP CCBs) possess combined P-glycoprotein and moderate CYP3A4 inhibition, which may lead to increased exposure of medications that are substrates for these metabolic pathways, such as rivaroxaban.	1,4-dihydropyridine	50-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111	
22644980-4	2012	While both dihydropyridine and nondihydropyridine CCBs are cytochrome P-450 isoenzyme 3A4 (CYP3A4) substrates, verapamil was the CCB implicated in three of the five case reports.	1,4-dihydropyridine	11-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-89	
22644980-4	2012	While both dihydropyridine and nondihydropyridine CCBs are cytochrome P-450 isoenzyme 3A4 (CYP3A4) substrates, verapamil was the CCB implicated in three of the five case reports.	1,4-dihydropyridine	11-26	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97	
24301608-0	2014	Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation.	1,4-dihydropyridine	77-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	61-67	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	53-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-149	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	53-73	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	75-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-149	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	75-83	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	75-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-149	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	75-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157	
22161476-1	2012	The present study investigated inhibitory effects of 1,4-dihydropyridines (1,4-DHPs) calcium channel antagonists (1,4-DHP-CCAs) on cytochromeP450 3A4 (CYP3A4) of human liver microsomes and further explored importance of 1,4-DHPs molecular structural descriptors.	1,4-dihydropyridine	220-228	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	151-157	
22161476-2	2012	Partial Least Squares method was applied to probe the quantitative relationships between the 1,4-DHPs molecular structural descriptors and its inhibitory actions, which demonstrated that different 1,4-DHP-CCAs could inhibit CYP3A4 enzyme"s activity differently.	1,4-dihydropyridine	93-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	224-230	
22161476-2	2012	Partial Least Squares method was applied to probe the quantitative relationships between the 1,4-DHPs molecular structural descriptors and its inhibitory actions, which demonstrated that different 1,4-DHP-CCAs could inhibit CYP3A4 enzyme"s activity differently.	1,4-dihydropyridine	93-100	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	224-230	
22161476-6	2012	It is concluded that analysis of K (i) of 1,4-DHPs derivatives on the CYP3A4 activity may apply for the QSAR formula at the initial stage of clinical application of new drugs.	1,4-dihydropyridine	42-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76	
19007592-2	2008	BACKGROUND: Clopidogrel is activated by CYP3A4, which also metabolizes CCBs of the dihydropyridine class.	1,4-dihydropyridine	83-98	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46	
17327696-7	2007	To date, the dihydropyridine family, including Nic, has been believed to have inhibitory effects on the activity of various cytochrome P450 enzymes, especially human CYP3A4.	1,4-dihydropyridine	13-28	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	166-172	
11770832-3	2001	METHOD: CYP3A4 activities in human liver microsomes from 2 donors were determined using the oxidation of the dihydropyridine denitronifedipine, a specific CYP3A4 substrate, at a concentration of 50 microM (= KM).	1,4-dihydropyridine	109-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	8-14	
11770832-3	2001	METHOD: CYP3A4 activities in human liver microsomes from 2 donors were determined using the oxidation of the dihydropyridine denitronifedipine, a specific CYP3A4 substrate, at a concentration of 50 microM (= KM).	1,4-dihydropyridine	109-124	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-161	
11501176-9	2000	Cytochrome P-4503A (CYP3A) is involved in the dehydrogenation of dihydropyridine ring of NDP.	1,4-dihydropyridine	65-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-18	
11501176-9	2000	Cytochrome P-4503A (CYP3A) is involved in the dehydrogenation of dihydropyridine ring of NDP.	1,4-dihydropyridine	65-80	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-25