PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7033271-2 1982 After a 24-h preincubation with maximal stimulatory concentrations of phenformin, specific [125I] insulin binding to its receptors in the four different cell lines were increased over control by 67.2 +/ 17.0%, 101.3 +/- 11.5%, 65.1 +/- 8.0%, and 44.0 +/- 12.1%, respectively (mean +/- SE). Phenformin 70-80 insulin Homo sapiens 98-105 6327744-0 1984 The effect of phenformin and other adenosine triphosphate (ATP)-lowering agents on insulin binding to IM-9 human cultured lymphocytes. Phenformin 14-24 insulin Homo sapiens 83-90 6327744-2 1984 After a 24-hr preincubation, phenformin induced a twofold increase in specific 125I-insulin binding, and removal of phenformin was followed 6 hr later by a return in binding to control levels. Phenformin 29-39 insulin Homo sapiens 84-91 6327744-3 1984 This effect of phenformin on insulin binding was not a consequence of either inhibition of cell growth, changes in cellular cyclic adenosine monophosphate (AMP) levels, or changes in guanosine triphosphate (GTP) content. Phenformin 15-25 insulin Homo sapiens 29-36 6327744-5 1984 The phenformin-induced increase in insulin binding to IM-9 cells was related to a time- and dose-dependent decrease in ATP levels. Phenformin 4-14 insulin Homo sapiens 35-42 6327744-7 1984 These studies indicated, therefore, that phenformin enhances insulin binding to receptors on IM-9 cells and that this effect on insulin receptors may be related to alterations in metabolic functions that are reflected by a lowering of ATP levels. Phenformin 41-51 insulin Homo sapiens 61-68 6327744-7 1984 These studies indicated, therefore, that phenformin enhances insulin binding to receptors on IM-9 cells and that this effect on insulin receptors may be related to alterations in metabolic functions that are reflected by a lowering of ATP levels. Phenformin 41-51 insulin Homo sapiens 128-135 6345751-3 1983 The antidiabetic action of phenformin and other related biguanides can be explained in terms of competition between these molecules and insulin to coordinate cationic oligoelements together with their ability to form hydrogen bonds between the biguanide moiety and insulin itself. Phenformin 27-37 insulin Homo sapiens 136-143 6345751-3 1983 The antidiabetic action of phenformin and other related biguanides can be explained in terms of competition between these molecules and insulin to coordinate cationic oligoelements together with their ability to form hydrogen bonds between the biguanide moiety and insulin itself. Phenformin 27-37 insulin Homo sapiens 265-272 6290837-0 1982 Phenformin has opposite effects on insulin and growth hormone binding to IM-9 lymphocytes. Phenformin 0-10 insulin Homo sapiens 35-42 6290837-1 1982 We studied simultaneously the effect of various concentrations of phenformin on insulin and growth hormone binding to IM-9 lymphocytes, a cell type known to have receptors for both these hormones. Phenformin 66-76 insulin Homo sapiens 80-87 6290837-2 1982 After 24 hr preincubation with phenformin at 2 x 10(-5) M, insulin binding to IM-9 cells was increased by 80.4 +/- 10.5% over control (mean +/- SE of 10 experiments). Phenformin 31-41 insulin Homo sapiens 59-66 6290837-4 1982 This effect of phenformin was dose-dependent for both HGH and insulin binding over the concentration range 1.5 x 10(-6) M to 5 x 10(-5) M, and was already detectable 3 hr after phenformin addition. Phenformin 15-25 insulin Homo sapiens 62-69 6290837-4 1982 This effect of phenformin was dose-dependent for both HGH and insulin binding over the concentration range 1.5 x 10(-6) M to 5 x 10(-5) M, and was already detectable 3 hr after phenformin addition. Phenformin 177-187 insulin Homo sapiens 62-69 6290837-5 1982 These data indicate that phenformin has an opposite effect on insulin and growth hormone binding to IM-9 cells. Phenformin 25-35 insulin Homo sapiens 62-69 6290837-6 1982 Several possible mechanisms might be suggested for the decrease of HGH binding sites induced by phenformin: the simultaneous opposite effect on HGH and insulin receptors raises the possibility that some metabolic event triggered by the drug is able to induce opposite changes in the binding of these two hormones with different biological activities. Phenformin 96-106 insulin Homo sapiens 152-159 6734405-3 1984 In contrast the two biguanides tested, phenformin and metformin, increased insulin binding in all cell types by 44 to 101%. Phenformin 39-49 insulin Homo sapiens 75-82 7033271-3 1982 Phenformin was effective in IM-9 cells that were down-regulated by unlabeled insulin, and the effect of phenformin on insulin binding was not affected by inhibition of protein synthesis with cycloheximide. Phenformin 0-10 insulin Homo sapiens 77-84 7033271-3 1982 Phenformin was effective in IM-9 cells that were down-regulated by unlabeled insulin, and the effect of phenformin on insulin binding was not affected by inhibition of protein synthesis with cycloheximide. Phenformin 104-114 insulin Homo sapiens 118-125 7033271-5 1982 Scatchard plots indicated that phenformin increased the insulin receptor"s affinity rather than the number of insulin-binding sites on IM-9 cells. Phenformin 31-41 insulin Homo sapiens 56-63 7020090-10 1981 Insulin therapy has been found to be quite useful in the treatment of phenformin-associated lactic acidosis and is recommended in this setting. Phenformin 70-80 insulin Homo sapiens 0-7 908474-3 1977 Phenformin was found to decrease postprandial hyperglycaemia significantly when compared with control values, and its addition to insulin further decreased the postprandial glucose rise below that found with insulin alone (p less than 0.005). Phenformin 0-10 insulin Homo sapiens 208-215 7024393-0 1981 Phenformin stimulation of insulin binding to human cultured lymphocytes. Phenformin 0-10 insulin Homo sapiens 26-33 7024393-1 1981 The effects of the oral hypoglycemic agent, phenformin, were studied on the binding of 125I-insulin to its receptors in IM-9 human cultured lymphocytes. Phenformin 44-54 insulin Homo sapiens 92-99 7024393-2 1981 Three h after the addition of 5 microgram/ml of phenformin to these cells there was detectable stimulation of 125I-insulin binding; maximal effects were seen after 18 h. A detectable effect of phenformin was seen at 1 microgram/ml and maximal effects were seen at 5 microgram/ml. Phenformin 48-58 insulin Homo sapiens 115-122 7024393-2 1981 Three h after the addition of 5 microgram/ml of phenformin to these cells there was detectable stimulation of 125I-insulin binding; maximal effects were seen after 18 h. A detectable effect of phenformin was seen at 1 microgram/ml and maximal effects were seen at 5 microgram/ml. Phenformin 193-203 insulin Homo sapiens 115-122 7024393-3 1981 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin 41-51 insulin Homo sapiens 82-89 7024393-3 1981 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin 152-162 insulin Homo sapiens 82-89 7024393-3 1981 These studies demonstrate therefore than phenformin increases the binding of 125I-insulin to human cultured lymphocytes, and raise the possibility that phenformin could act in vivo to regulate insulin receptors. Phenformin 152-162 insulin Homo sapiens 193-200 6987125-0 1980 Phenformin increases insulin binding to human cultured breast cancer cells. Phenformin 0-10 insulin Homo sapiens 21-28 6987125-1 1980 The effect of the hypoglycemic biguanide, phenformin, on the binding of insulin to MCF-7 cells, an in vitro line derived from a human breast cancer, has been investigated. Phenformin 42-52 insulin Homo sapiens 72-79 6987125-2 1980 Cells incubated for 24 h in the presence of 1.0 micrograms/ml of phenformin bound 62.2 +/- 8.1% (mean +/- SE) more 125I-insulin than did controls. Phenformin 65-75 insulin Homo sapiens 120-127 6987125-5 1980 This demonstration of increased receptor number in response to phenformin exposure provides support for the hypothesis that one action of phenformin is to enhance tissue sensitivity to insulin. Phenformin 63-73 insulin Homo sapiens 185-192 6987125-5 1980 This demonstration of increased receptor number in response to phenformin exposure provides support for the hypothesis that one action of phenformin is to enhance tissue sensitivity to insulin. Phenformin 138-148 insulin Homo sapiens 185-192 368813-0 1979 Insulin-lowering effect of phenformin not mediated by inhibition of gastric inhibitory polypeptide. Phenformin 27-37 insulin Homo sapiens 0-7 921092-4 1977 Taken together with results from animal studies, these data suggest that insulin is the treatment of choice for phenformin-associated lactic acidosis. Phenformin 112-122 insulin Homo sapiens 73-80 1181670-12 1975 During oral glucose loading phenformin caused a significant fall in blood glucose levels, accompanied by an increased insulin response in one patient. Phenformin 28-38 insulin Homo sapiens 118-125 13950627-0 1963 Reduction by phenformin of excessive insulin levels after glucose loading in obese and diabetic subjects. Phenformin 13-23 insulin Homo sapiens 37-44 1138241-0 1975 [Effect of phenformin on plasma levels of insulin, growth hormone, and pancreatic as well as intestinal glucagon in diabetics]. Phenformin 11-21 insulin Homo sapiens 42-49 804684-0 1975 [Daily curves of blood sugar and serum insulin after treatment with various combinations of glibenclamide and phenformin]. Phenformin 110-120 insulin Homo sapiens 39-46 1120543-0 1975 Insulin therapy in phenformin-associated lactic acidosis; a case report, biochemical considerations and review of the literature. Phenformin 19-29 insulin Homo sapiens 0-7 1120543-1 1975 A patient with phenformin-associated lactic acidosis was treated with insulin and showed marked improvement coincident with the expected onset of action of the insulin administered. Phenformin 15-25 insulin Homo sapiens 70-77 1120543-1 1975 A patient with phenformin-associated lactic acidosis was treated with insulin and showed marked improvement coincident with the expected onset of action of the insulin administered. Phenformin 15-25 insulin Homo sapiens 160-167 4995366-0 1971 [Experimental demonstration of the simulating action of biguanides (phenformin, metformin) on insulin secretion]. Phenformin 68-78 insulin Homo sapiens 94-101 4914612-3 1970 Eleven patients while on phenformin noticed hypoglycaemic effects and reduced their insulin on average by almost 20% without resultant rise in blood sugar levels. Phenformin 25-35 insulin Homo sapiens 84-91 5377002-0 1969 [Association of phenformin with insulin therapy in treatment of diabetes in children and adolescents]. Phenformin 16-26 insulin Homo sapiens 32-39 6005291-0 1966 [Study on the effect of phenethylbiguanide on responses to insulin, tolbutamide and glucose in diabetes mellitus]. Phenformin 24-42 insulin Homo sapiens 59-66 4570364-0 1972 Increased levels of plasma insulin and eleven hydroxycorticosteroid induced by sucrose, and their reduction by phenformin. Phenformin 111-121 insulin Homo sapiens 27-34 5241474-0 1968 Effects of phenformin on insulin reserve and release. Phenformin 11-21 insulin Homo sapiens 25-32 5941678-0 1966 [Effect of phenylethylbiguanide on the response to insulin, tolbutamide and glucose administration in patients with diabetes mellitus]. Phenformin 11-31 insulin Homo sapiens 51-58 14475248-0 1962 On the use of phenformin to reduce high insulin requirements in diabetes mellitus. Phenformin 14-24 insulin Homo sapiens 40-47 13964514-0 1962 [Phenylethylbiguanide (DBI) in diabetes treated with insulin]. Phenformin 1-21 insulin Homo sapiens 53-60 9101010-4 1997 Studies using phenformin with insulin were also included due to its similarities to metformin. Phenformin 14-24 insulin Homo sapiens 30-37