PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34051271-4 2021 The role of aryl hydrocarbon receptor (AhR) and NF-kappaB signaling pathways involved in BaP-induced oxidative stress and inflammation was further investigated. benzylaminopurine 89-92 aryl hydrocarbon receptor Homo sapiens 39-42 34051271-4 2021 The role of aryl hydrocarbon receptor (AhR) and NF-kappaB signaling pathways involved in BaP-induced oxidative stress and inflammation was further investigated. benzylaminopurine 89-92 aryl hydrocarbon receptor Homo sapiens 12-37 34051271-7 2021 Furthermore, BaP treatment of HUVECs activated AhR and NF-kappaB signaling pathways, and promoted reactive oxygen species generation and inflammatory cytokine release. benzylaminopurine 13-16 aryl hydrocarbon receptor Homo sapiens 47-50 34051271-8 2021 The current findings suggest that BaP induced inflammatory cytokine release from HUVECs through oxidative stress accompanied with AhR and NF-kappaB pathway activation. benzylaminopurine 34-37 aryl hydrocarbon receptor Homo sapiens 130-133 30294794-7 2019 Activation of AhR by BaP induced invasion as well as migration in MDA-MB-231 cells, which was blocked by AhR antagonist. benzylaminopurine 21-24 aryl hydrocarbon receptor Homo sapiens 14-17 30294794-1 2019 Benzo[alpha]pyrene (BaP) can have significant role in the development of breast cancer via aryl hydrocarbon receptor (AhR) activation. benzylaminopurine 20-23 aryl hydrocarbon receptor Homo sapiens 91-116 30294794-1 2019 Benzo[alpha]pyrene (BaP) can have significant role in the development of breast cancer via aryl hydrocarbon receptor (AhR) activation. benzylaminopurine 20-23 aryl hydrocarbon receptor Homo sapiens 118-121 30294794-4 2019 The aim of the present study was to examine the effect of BaP, an activator of AhR and cyclosporine A (CsA), as inhibitor of NFAT on migration and invasion of MDA-MB-231 cells. benzylaminopurine 58-61 aryl hydrocarbon receptor Homo sapiens 79-82 30294794-7 2019 Activation of AhR by BaP induced invasion as well as migration in MDA-MB-231 cells, which was blocked by AhR antagonist. benzylaminopurine 21-24 aryl hydrocarbon receptor Homo sapiens 105-108 30294794-9 2019 In these cells, BaP significantly reduced AhR expression while this reduction was reversed by CH-223191; however, CsA treatment lowered the AhR expression only at low dose. benzylaminopurine 16-19 aryl hydrocarbon receptor Homo sapiens 42-45 27452439-3 2016 We hypothesized that exposure of human fetoplacental endothelial cells (ECs) to the PAH benzo[a]yrene (BaP) would result in up-regulation of cyclooxygenase-2 (PTGS2) and preferential production of vasoconstrictive prostanoids via activation of the aryl hydrocarbon receptor (AHR) pathway. benzylaminopurine 103-106 aryl hydrocarbon receptor Homo sapiens 248-273 30342413-9 2018 The strongest AhR agonist activity was detected in B3-S, with 450 +- 20 mug BaP/L equivalency at 5 x exposure. benzylaminopurine 76-79 aryl hydrocarbon receptor Homo sapiens 14-17 27452439-3 2016 We hypothesized that exposure of human fetoplacental endothelial cells (ECs) to the PAH benzo[a]yrene (BaP) would result in up-regulation of cyclooxygenase-2 (PTGS2) and preferential production of vasoconstrictive prostanoids via activation of the aryl hydrocarbon receptor (AHR) pathway. benzylaminopurine 103-106 aryl hydrocarbon receptor Homo sapiens 275-278 27452439-11 2016 DISCUSSION: BaP-mediated AHR activation results in induction of PTGS2 expression and enhanced production of prostacyclin metabolite. benzylaminopurine 12-15 aryl hydrocarbon receptor Homo sapiens 25-28 27452439-12 2016 Despite an increase in this vasodilatory and pro-angiogenic prostanoid, BaP exposure also impairs EC migration and angiogenesis through AHR. benzylaminopurine 72-75 aryl hydrocarbon receptor Homo sapiens 136-139 25215666-5 2014 BaP and other PAHs are known to enter the cell via aromatic hydrocarbon receptor (AHR). benzylaminopurine 0-3 aryl hydrocarbon receptor Homo sapiens 82-85 25913286-7 2016 Further, docking of BaP and chrysene with the TiO2 NP bound AHR complex revealed their strong adsorption on TiO2 NP itself, and not on their original binding site (at AHR). benzylaminopurine 20-23 aryl hydrocarbon receptor Homo sapiens 60-63 25215666-6 2014 TiO2 NP showed a much higher docking score with AHR (12074) as compared to the docking score of BaP with AHR (4600). benzylaminopurine 96-99 aryl hydrocarbon receptor Homo sapiens 105-108 25215666-7 2014 This indicates a preferential binding of TiO2 NP with the AHR, in case if both the TiO2 NP and BaP are present. benzylaminopurine 95-98 aryl hydrocarbon receptor Homo sapiens 58-61 25215666-8 2014 Further, we have done the docking of BaP with the TiO2 NP bound AHR-complex (score 4710), and observed that BaP showed strong adsorption on TiO2 NP itself, and not at its original binding site (at AHR). benzylaminopurine 37-40 aryl hydrocarbon receptor Homo sapiens 64-67 25215666-8 2014 Further, we have done the docking of BaP with the TiO2 NP bound AHR-complex (score 4710), and observed that BaP showed strong adsorption on TiO2 NP itself, and not at its original binding site (at AHR). benzylaminopurine 108-111 aryl hydrocarbon receptor Homo sapiens 64-67 25215666-8 2014 Further, we have done the docking of BaP with the TiO2 NP bound AHR-complex (score 4710), and observed that BaP showed strong adsorption on TiO2 NP itself, and not at its original binding site (at AHR). benzylaminopurine 108-111 aryl hydrocarbon receptor Homo sapiens 197-200 25215666-9 2014 TiO2 NPs thereby prevent the entry of BaP in to the cell via AHR and hence protect cells against the deleterious effects induced by BaP. benzylaminopurine 38-41 aryl hydrocarbon receptor Homo sapiens 61-64 19854261-0 2010 Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes. benzylaminopurine 47-68 aryl hydrocarbon receptor Homo sapiens 84-87 15041469-5 2004 Although BaP, 2,3,7,8-tetrachlorodibenzo-p-dixin and polychlorinated biphenyl 126 activated aryl hydrocarbon receptor (AhR), which subsequently induced cytochrome P4501A1 (CYP1A1) and P4501B1 (CYP1B1) expression in H1355 cells, unexpectedly, neither TCDD nor PCB126 reduced AR expression. benzylaminopurine 9-12 aryl hydrocarbon receptor Homo sapiens 92-117 15041469-5 2004 Although BaP, 2,3,7,8-tetrachlorodibenzo-p-dixin and polychlorinated biphenyl 126 activated aryl hydrocarbon receptor (AhR), which subsequently induced cytochrome P4501A1 (CYP1A1) and P4501B1 (CYP1B1) expression in H1355 cells, unexpectedly, neither TCDD nor PCB126 reduced AR expression. benzylaminopurine 9-12 aryl hydrocarbon receptor Homo sapiens 119-122