PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12505323-9 2002 In summary, we have found that protection by GSTs against B[a]P or DiB[a,l]P toxicity is highly variable depending on differences in: (a) the PAH structure; (b) the human vs. rat CYP1A1 expressed; (c) GST isozyme(s) expressed; (d) cellular expression of conjugate transporters; or (e) DNA damage versus cytoxicity end-points. p-Aminohippuric Acid 142-145 glutathione S-transferase mu 1 Homo sapiens 45-49 23867956-8 2013 The PAH-DNA adduct levels in the subgroup with GSTM1 null genotype was 2-fold higher than in individuals with GSTM1 active (7.06+-5.12 vs. 13.14+-9.81 adduct/10(8) nucleotides). p-Aminohippuric Acid 4-7 glutathione S-transferase mu 1 Homo sapiens 47-52 23867956-8 2013 The PAH-DNA adduct levels in the subgroup with GSTM1 null genotype was 2-fold higher than in individuals with GSTM1 active (7.06+-5.12 vs. 13.14+-9.81 adduct/10(8) nucleotides). p-Aminohippuric Acid 4-7 glutathione S-transferase mu 1 Homo sapiens 110-115 18314648-3 2007 Enzymes involved in Policyclic Aromatic hidrocarbures (PAH) metabolism and degradation are polymorphic in humans, including glutation S-transferases (GSTs), N-acetiltransferases (NATs), sulfotransferases (SULTs)1A1 and cytochrome p450 (CYP)1B1. p-Aminohippuric Acid 55-58 glutathione S-transferase mu 1 Homo sapiens 150-154 10712743-2 2000 GSTP1 and GSTM1 are mainly involved in detoxification reactions of PAH carcinogenic intermediates produced by cytochrome P450 (CYP). p-Aminohippuric Acid 67-70 glutathione S-transferase mu 1 Homo sapiens 10-15 11535249-6 2001 Our results suggest interactions between GSTM1 and GSTP1 alleles in modulation of urinary 1-OHPY levels and white blood cell DNA adduct levels in the PAH-exposed workers. p-Aminohippuric Acid 150-153 glutathione S-transferase mu 1 Homo sapiens 41-46 10712743-10 2000 Our data show that the combined GSTM1 and GSTP1 genetic polymorphisms may modulate PAH-DNA adduct levels in mononuclear WBCs from individuals exposed to specific carcinogenic compounds, e.g., tobacco smoke, in relatively lower-exposure environmental conditions (i.e., in summer). p-Aminohippuric Acid 83-86 glutathione S-transferase mu 1 Homo sapiens 32-37 10650914-5 1999 A statistically significant association was observed between increased PAH-DNA adduct levels and the more susceptible GSTM1- genotype (P.O.R. p-Aminohippuric Acid 71-74 glutathione S-transferase mu 1 Homo sapiens 118-123 10650914-6 1999 = 4.18, P = 0.03) in a logistic regression modelling and a significant interaction between PAH exposure and GSTM1-genotype was found for PAH-DNA adducts. p-Aminohippuric Acid 91-94 glutathione S-transferase mu 1 Homo sapiens 108-113 10650914-6 1999 = 4.18, P = 0.03) in a logistic regression modelling and a significant interaction between PAH exposure and GSTM1-genotype was found for PAH-DNA adducts. p-Aminohippuric Acid 137-140 glutathione S-transferase mu 1 Homo sapiens 108-113 10650914-8 1999 In conclusion, a gene-environment interaction between PAH exposure and two metabolic genotypes involved in activation (CYP1A1) and detoxification (GSTM1) of PAHs, respectively, has been identified. p-Aminohippuric Acid 54-57 glutathione S-transferase mu 1 Homo sapiens 147-152 10571654-5 1999 Results from lung cancer patients and PAH-exposed coke oven workers correlated CYP1A1-GSTM1 genotype combinations with BPDE-DNA adduct levels. p-Aminohippuric Acid 38-41 glutathione S-transferase mu 1 Homo sapiens 86-91 10493307-2 1999 In the study, the effect of the GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms was investigated in relation to PAH-DNA adduct levels in non-tumourous lung tissue from non-small cell lung cancer (NSCLC) patients living in the industrialized region of Upper Silesia, Poland. p-Aminohippuric Acid 110-113 glutathione S-transferase mu 1 Homo sapiens 32-37 7666479-13 1995 Separately, the presence of PAH-dGMP adducts was associated with the GSTM1 null genotype (absence of the gene) (odds ratio = 8.6; 95% confidence interval = 1.03-100). p-Aminohippuric Acid 28-31 glutathione S-transferase mu 1 Homo sapiens 69-74 7666479-15 1995 CYP2D6 and CYP2E1 genotypes are associated with higher 7-methyl-dGMP levels, while the GSTM1 null genotype is associated with higher numbers of PAH-dGMP adducts. p-Aminohippuric Acid 144-147 glutathione S-transferase mu 1 Homo sapiens 87-92