PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20400267-4 2010 Polycylic aromatic hydrocarbons (PAH) are environmental toxicants that can be metabolized by two phase I enzymes, cytochrome P450 1A1 and 1B1. p-Aminohippuric Acid 33-36 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-141 21879948-5 2011 Whatever the site, the finest PM (UF and F) induced the mRNA expression of CYP1A1, a biomarker of polyaromatic hydrocarbons (PAH) exposure, NQO-1 and heme HO-1, two antioxidant responsive element-driven genes; and two effect biomarkers, GM-CSF, a proinflammatory cytokine and amphiregulin (AR), a growth factor. p-Aminohippuric Acid 125-128 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 10613181-0 1999 Mutagenicity of C24H14 PAH in human cells expressing CYP1A1. p-Aminohippuric Acid 23-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 19302717-11 2009 Finally, Cytochrome P450 1A1 activity that reflects PAH bioavailability varied as a function of the season: it was maximal for the fine fraction in winter and for the ultrafine fraction in summer. p-Aminohippuric Acid 52-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 9-28 15316568-1 2004 Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. p-Aminohippuric Acid 21-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 12507920-2 2002 The ratio between CYP1A1 and GST enzyme activities is a critical determinant of the target dose of carcinogenic BPDE and other DNA-reactive PAH metabolites. p-Aminohippuric Acid 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 10650914-2 1999 In order to assess whether the levels of some biomarkers (PAH-DNA adducts, nitro-PAH adducts to Hb and MN frequency) could be modulated by the genetic metabolic polymorphisms for CYP1A1 and GSTM1, we analysed in 76 coke-oven workers and 18 controls the CYP1A1 (MspI and Ile/Val sites) and the GSTM1 genotypes by a PCR assay. p-Aminohippuric Acid 58-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 179-185 10650914-2 1999 In order to assess whether the levels of some biomarkers (PAH-DNA adducts, nitro-PAH adducts to Hb and MN frequency) could be modulated by the genetic metabolic polymorphisms for CYP1A1 and GSTM1, we analysed in 76 coke-oven workers and 18 controls the CYP1A1 (MspI and Ile/Val sites) and the GSTM1 genotypes by a PCR assay. p-Aminohippuric Acid 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 179-185 10650914-4 1999 Statistically significant (P = 0.03 and P = 0.01) higher percentages of the more susceptible GSTM1- subjects compared to the GSTM1+ subjects and of the more susceptible CYP1A1 Ile/Val individuals compared to the CYP1A1 Ile/Ile individuals were detected for high levels of PAH-DNA adducts in the high exposure group (namely high levels of 1-OHP). p-Aminohippuric Acid 272-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-175 10650914-8 1999 In conclusion, a gene-environment interaction between PAH exposure and two metabolic genotypes involved in activation (CYP1A1) and detoxification (GSTM1) of PAHs, respectively, has been identified. p-Aminohippuric Acid 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 15534862-11 2004 The similarities between the DNA adduct patterns produced by DBC and MeDBC in V79MZh1A1 and V79MZh1A2 cells suggest that biotransformation mediated via CYP1A1 and CYP1A2 might depend on a PAH-type pathway involving the aromatic ring system. p-Aminohippuric Acid 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 152-158 11054538-1 2000 Tetrapod cytochrome P4501 family (CYP1A1, CYP1A2 and CYP1B1) enzymes are most active in hydroxylating a variety of environmental contaminants including polyaromatic hydrocarbons (PAH), planar polychlorinated biphenyls and arylamines and thus play a pivotal role in the toxicology of these compounds. p-Aminohippuric Acid 179-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 10613181-3 1999 h1A1v2 cells are a line of human B-lymphoblastoid cells that have been engineered to express cytochrome P4501A1 (CYP1A1), an enzyme capable of metabolizing promutagenic PAH. p-Aminohippuric Acid 169-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 93-111 10613181-3 1999 h1A1v2 cells are a line of human B-lymphoblastoid cells that have been engineered to express cytochrome P4501A1 (CYP1A1), an enzyme capable of metabolizing promutagenic PAH. p-Aminohippuric Acid 169-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 113-119 10493307-2 1999 In the study, the effect of the GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms was investigated in relation to PAH-DNA adduct levels in non-tumourous lung tissue from non-small cell lung cancer (NSCLC) patients living in the industrialized region of Upper Silesia, Poland. p-Aminohippuric Acid 110-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-52 10493307-10 1999 Thus, our findings imply that the GSTMI and CYP1A1 exon 7 polymorphisms may influence PAH-DNA adduct levels in target tissue from NSCLC patients, especially in the squamous cell carcinoma group. p-Aminohippuric Acid 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 10571654-5 1999 Results from lung cancer patients and PAH-exposed coke oven workers correlated CYP1A1-GSTM1 genotype combinations with BPDE-DNA adduct levels. p-Aminohippuric Acid 38-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 9711266-9 1998 When confounding factors associated with PAH exposure were taken into account a statistically significant effect of CYP1A1 exon 7 polymorphism on DNA adduct levels was found (p = 0.012 in mononuclear WBCs, p = 0.043 in granulocytes). p-Aminohippuric Acid 41-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 116-122 30743243-7 2019 According to the high concentrations of PAH and other related organic chemicals found in this OEM, CYP1A1 and 1B1 genes exhibited high transcription levels in BEAS-2B cells, thereby supporting both the activation of the critical AhR signaling pathway and the formation of highly reactive ultimate metabolites. p-Aminohippuric Acid 40-43 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-113 9744534-5 1998 The relationships in human placenta between DNA damage, CYP1A1 activity and genotype have not been well characterized and may be relevant to risks from transplacental PAH exposure. p-Aminohippuric Acid 167-170 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 9744534-9 1998 Placental PAH-DNA adduct levels were significantly higher in infants with the CYP1A1 MspI restriction site compared with infants without the restriction site (P < 0.01), implicating a genetic factor in inter-individual variation in DNA damage in human placenta. p-Aminohippuric Acid 10-13 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84