PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24166669-6 2013 RESULTS: Expression of rat OAT1 (rOAT1) and rOAT3 stimulated uptake of their typical substrates, p-aminohippurate and estrone sulfate, respectively, into oocytes, and caffeic acid inhibited them dose dependently. p-Aminohippuric Acid 97-113 solute carrier family 22 member 6 Rattus norvegicus 27-31 25883984-4 2015 The renal transport function was assessed by the uptake of para-aminohippurate mediated organic anion transporters 1 (Oat1) and 3 (Oat3), using renal cortical slices. p-Aminohippuric Acid 59-78 solute carrier family 22 member 6 Rattus norvegicus 88-129 25883984-7 2015 The baseline uptake of para-aminohippurate was not different among experimental groups and was correlated with Oat1 and 3 mRNA expressions. p-Aminohippuric Acid 23-42 solute carrier family 22 member 6 Rattus norvegicus 111-121 24744908-0 2014 PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 103-107 24744908-6 2014 PAH extraction directly correlated with the expression of basolateral Oat1 and Oat3. p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 70-74 24166669-6 2013 RESULTS: Expression of rat OAT1 (rOAT1) and rOAT3 stimulated uptake of their typical substrates, p-aminohippurate and estrone sulfate, respectively, into oocytes, and caffeic acid inhibited them dose dependently. p-Aminohippuric Acid 97-113 solute carrier family 22 member 6 Rattus norvegicus 33-38 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 43-76 22027505-7 2012 Para-aminohippuric acid (PAH) significantly reduced the intracellular accumulation of AAI in rOAT1-transfected HEK293 cells. p-Aminohippuric Acid 0-23 solute carrier family 22 member 6 Rattus norvegicus 93-98 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 149-153 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 22-25 solute carrier family 22 member 6 Rattus norvegicus 43-76 22273603-5 2012 p-Aminohippuric acid (PAH), a substrate of organic anion transporter (OAT) 1, benzylpenicillin (PCG), a substrate of OAT3 and JBP485, a substrate of OAT1 and OAT3, reduced the uptake of bestatin in rat kidney slices and in hOAT1- or hOAT3-HEK 293 cells. p-Aminohippuric Acid 22-25 solute carrier family 22 member 6 Rattus norvegicus 149-153 22759781-8 2012 The renal clearance of p-aminohippurate (PAH, a prototypical organic anion, substrate of Oat1 and Oat3) was measured by conventional clearance techniques. p-Aminohippuric Acid 23-39 solute carrier family 22 member 6 Rattus norvegicus 89-93 19533102-3 2009 The lower protein levels of Oat1 and Oat3 in basolateral membranes explain the lower uptake capacity for p-aminohippurate (in vitro assays) and the diminution of the systemic clearance of this organic anion (in vivo studies) observed in treated rats. p-Aminohippuric Acid 105-121 solute carrier family 22 member 6 Rattus norvegicus 28-32 19915082-7 2010 Perfluorohexanoate (C6), C7, and C8 inhibited Oat1-mediated p-aminohippurate transport, with C7 being the strongest inhibitor. p-Aminohippuric Acid 60-76 solute carrier family 22 member 6 Rattus norvegicus 46-50 19111004-8 2008 Because mRNA expression of OAT1, OAT3, and GS was decreased substantially, we ascribe the fall of p-aminohippurate accumulation and GS activity to alterations at the transcriptional level. p-Aminohippuric Acid 98-114 solute carrier family 22 member 6 Rattus norvegicus 27-31 19439489-6 2009 The renal secretion of YM-385461, one derivative of p-aminohippuric acid, via hOAT1/rOat1, and hepatic uptake of YM-252124 via hOCT1/rOct1 was also expected. p-Aminohippuric Acid 52-72 solute carrier family 22 member 6 Rattus norvegicus 84-89 18922885-3 2008 Recently, we reported that cadaveric renal allografts exhibit maldistribution of organic anion transporter 1 (OAT1) in proximal tubule cells after ischemia and reperfusion, resulting in impairment of PAH clearance. p-Aminohippuric Acid 200-203 solute carrier family 22 member 6 Rattus norvegicus 81-108 18922885-3 2008 Recently, we reported that cadaveric renal allografts exhibit maldistribution of organic anion transporter 1 (OAT1) in proximal tubule cells after ischemia and reperfusion, resulting in impairment of PAH clearance. p-Aminohippuric Acid 200-203 solute carrier family 22 member 6 Rattus norvegicus 110-114 19403644-7 2009 Moreover, the interaction among citrulline, PAH, and probenecid uptakes via rat Oat1 suggested that there are multiple functional sites on Oat1 and that the citrulline site may be distinct from the PAH and probenecid site. p-Aminohippuric Acid 44-47 solute carrier family 22 member 6 Rattus norvegicus 80-84 18953184-7 2008 A direct correlation was observed between the secretory clearance of PAH and Oat1 (r(2) = 0.88) and Oat3 (r(2) = 0.83) expression in basolateral membranes. p-Aminohippuric Acid 69-72 solute carrier family 22 member 6 Rattus norvegicus 77-81 16844357-12 2006 The present study demonstrates the key role of OAT1 expression in the impaired elimination of PAH after 3 days of obstructive cholestasis. p-Aminohippuric Acid 94-97 solute carrier family 22 member 6 Rattus norvegicus 47-51 17971680-12 2008 CONCLUSIONS: The decrease in PAH elimination observed in an early stage of renal ischemia-reperfusion in male Wistar rats might be explained by the sum of the lower OAT1 and OAT3 expression in renal basolateral plasma membranes plus the decrease in cRBF. p-Aminohippuric Acid 29-32 solute carrier family 22 member 6 Rattus norvegicus 165-169 17244891-4 2007 Using a rat model of iARF, we investigated whether impairing the secretion of the organic anion PAH might be associated with downregulation of OAT1 or OAT3. p-Aminohippuric Acid 96-99 solute carrier family 22 member 6 Rattus norvegicus 143-147 17244891-10 2007 Thus decreased expression of OAT1 and OAT3 is sufficient to explain the decline of PAH secretion after iARF. p-Aminohippuric Acid 83-86 solute carrier family 22 member 6 Rattus norvegicus 29-33 12711831-1 2003 The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on P-aminohippurate (PAH) clearance, since it has been viewed as the prototypic organic anion. p-Aminohippuric Acid 262-278 solute carrier family 22 member 6 Rattus norvegicus 121-148 15846470-8 2005 Excess PAH, which could inhibit rOat1 and rOat3, completely inhibited the saturable uptake of IA, IS, and CMPF by the kidney, and by 85% for HA uptake. p-Aminohippuric Acid 7-10 solute carrier family 22 member 6 Rattus norvegicus 32-37 14734677-3 2004 It has been proposed that OAT1 is indirectly involved in PAH uptake via the Na(+) dicarboxylate cotransporter. p-Aminohippuric Acid 57-60 solute carrier family 22 member 6 Rattus norvegicus 26-30 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 50-77 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 79-84 12660303-1 2003 Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. p-Aminohippuric Acid 155-171 solute carrier family 22 member 6 Rattus norvegicus 86-93 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 75-91 solute carrier family 22 member 6 Rattus norvegicus 33-38 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 75-91 solute carrier family 22 member 6 Rattus norvegicus 142-147 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 93-96 solute carrier family 22 member 6 Rattus norvegicus 33-38 16325760-8 2005 The recombinant yeast expressing rOAT1 showed an increase in the uptake of p-aminohippurate (PAH) and this showed a positive correlation with rOAT1 expression level. p-Aminohippuric Acid 93-96 solute carrier family 22 member 6 Rattus norvegicus 142-147 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 6 Rattus norvegicus 112-139 15878738-3 2005 The objective of this work was to study, in rats with experimental CRF (5/6 nephrectomy), the expression of the organic anion transporter 1 (OAT1) and organic anion transporter 3 (OAT3) and their contribution to the pharmacokinetics and renal excretion of p-aminohippurate (PAH). p-Aminohippuric Acid 274-277 solute carrier family 22 member 6 Rattus norvegicus 141-145 15748710-6 2005 Basolateral PAH transport showed a higher correlation with the protein level of rOAT1 (r(2)=0.80) than rOAT3 (r(2)=0.34), whereas basolateral TEA transport showed a strong correlation with rOCT2 protein (r(2)=0.91). p-Aminohippuric Acid 12-15 solute carrier family 22 member 6 Rattus norvegicus 80-85 12954363-4 2003 p-Aminohippuric acid, a substrate of rat organic anion transporter1 (rOat1), and cimetidine, a substrate of rOat3, reduced the urinary excretion of phenolsulfonphthalein. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 41-67 12954363-4 2003 p-Aminohippuric acid, a substrate of rat organic anion transporter1 (rOat1), and cimetidine, a substrate of rOat3, reduced the urinary excretion of phenolsulfonphthalein. p-Aminohippuric Acid 0-20 solute carrier family 22 member 6 Rattus norvegicus 69-74 12711831-1 2003 The purpose of the present study was to examine in rats the effects of acute bile duct ligation on the expression of the organic anion transporter 1 in the kidney and the consequences of these effects on the systemic clearance of organic anions, particularly on P-aminohippurate (PAH) clearance, since it has been viewed as the prototypic organic anion. p-Aminohippuric Acid 280-283 solute carrier family 22 member 6 Rattus norvegicus 121-148 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 54-81 12488248-5 2003 Probenecid-sensitive uptake of p-aminohippurate (PAH, an Oat1 and Oat3 substrate) and estrone sulfate (ES, an Oat3 substrate) in rat Oat3-expressing oocytes was significantly trans-stimulated by preloading the oocytes with the dicarboxylate glutarate (GA). p-Aminohippuric Acid 31-47 solute carrier family 22 member 6 Rattus norvegicus 57-61 12488248-5 2003 Probenecid-sensitive uptake of p-aminohippurate (PAH, an Oat1 and Oat3 substrate) and estrone sulfate (ES, an Oat3 substrate) in rat Oat3-expressing oocytes was significantly trans-stimulated by preloading the oocytes with the dicarboxylate glutarate (GA). p-Aminohippuric Acid 49-52 solute carrier family 22 member 6 Rattus norvegicus 57-61 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 122-138 solute carrier family 22 member 6 Rattus norvegicus 0-4 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 122-138 solute carrier family 22 member 6 Rattus norvegicus 106-110 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 140-143 solute carrier family 22 member 6 Rattus norvegicus 0-4 12237339-7 2002 Oat1-mediated uptake of [(14)C]MeHg-NAC and [(14)C]MeHg-DMPS was inhibited by prototypical substrates for Oat1, including p-aminohippurate (PAH), and was trans-stimulated when oocytes were preloaded with 2 mM glutarate but not glutamate. p-Aminohippuric Acid 140-143 solute carrier family 22 member 6 Rattus norvegicus 106-110 12237339-8 2002 Conversely, efflux of [(3)H]PAH from Oat1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are transported solutes. p-Aminohippuric Acid 28-31 solute carrier family 22 member 6 Rattus norvegicus 37-41 12237339-8 2002 Conversely, efflux of [(3)H]PAH from Oat1-expressing oocytes was trans-stimulated by glutarate, PAH, NAC, DMPS, MeHg-NAC, MeHg-DMPS, and a mercapturic acid, indicating that these are transported solutes. p-Aminohippuric Acid 96-99 solute carrier family 22 member 6 Rattus norvegicus 37-41 12237339-9 2002 [(3)H]PAH uptake was competitively inhibited by NAC (K(i) of 2.0 +/- 0.3 mM) and DMPS (K(i) of 0.10 +/- 0.02 mM), providing further evidence that these chelating agents are substrates for Oat1. p-Aminohippuric Acid 6-9 solute carrier family 22 member 6 Rattus norvegicus 188-192 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 83-88 11961115-2 2002 In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP. p-Aminohippuric Acid 144-160 solute carrier family 22 member 6 Rattus norvegicus 90-97 12005172-3 2002 Various cephalosporin antibiotics significantly inhibited both estrone sulfate uptake in S2 rOAT3 and para-aminohippuric acid uptake in S2 rOAT1. p-Aminohippuric Acid 102-125 solute carrier family 22 member 6 Rattus norvegicus 139-144 12083373-0 2002 Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1. p-Aminohippuric Acid 19-39 solute carrier family 22 member 6 Rattus norvegicus 109-113 12083373-5 2002 The lower expression of OAT1 in BLMV in association with the higher BBMV fluidity (which may affect the affinity of PAH transporter in this membrane domain) observed in females may be responsible, at least in part, for the gender difference described in renal PAH secretion. p-Aminohippuric Acid 116-119 solute carrier family 22 member 6 Rattus norvegicus 24-28 11641438-5 2001 Uptake of [(3)H]p-aminohippuric acid (PAH) in Oat1-expressing Xenopus laevis oocytes was strongly inhibited by S-(2,4-dinitrophenyl)-N-acetyl-L-cysteine (DNP-NAC) and by all other mercapturic acids tested, including the endogenous mercapturic acid N-acetyl-leukotriene E(4). p-Aminohippuric Acid 38-41 solute carrier family 22 member 6 Rattus norvegicus 46-50 11861777-9 2002 These results suggest that rOat1 and rOat3 are mainly responsible for the renal uptake of PAH and pravastatin, respectively. p-Aminohippuric Acid 90-93 solute carrier family 22 member 6 Rattus norvegicus 27-32 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 6 Rattus norvegicus 0-5 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 70-86 solute carrier family 22 member 6 Rattus norvegicus 189-194 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 6 Rattus norvegicus 0-5 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 88-91 solute carrier family 22 member 6 Rattus norvegicus 189-194 11861777-5 2002 rOat1- and rOat3-expressed LLC-PK1 cells exhibited specific uptake of p-aminohippurate (PAH) and pravastatin, respectively, with the Michaelis-Menten constants (Km values) of 60 microM for rOat1-mediated PAH uptake and 13 microM for rOat3-mediated pravastatin uptake. p-Aminohippuric Acid 204-207 solute carrier family 22 member 6 Rattus norvegicus 0-5 15618660-4 2002 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. p-Aminohippuric Acid 67-83 solute carrier family 22 member 6 Rattus norvegicus 52-57 15618660-4 2002 The inhibition constants of these cephalosporins to rOAT1-mediated p-aminohippurate (PAH) uptake were 72 microM for cefazolin, 298 microM for cefoperazone, 718 microM for cefotiam and 6 mM for cephalexin. p-Aminohippuric Acid 85-88 solute carrier family 22 member 6 Rattus norvegicus 52-57 15618660-5 2002 Eadie-Hofstee plot analysis revealed that cefoperazone as well as cefotiam inhibited rOAT1-mediated PAH uptake competitively. p-Aminohippuric Acid 100-103 solute carrier family 22 member 6 Rattus norvegicus 85-90 11288487-6 2001 OAT1 mediates sodium-independent, anion exchange for a variety of organic anions including p-aminohippurate, cyclic nucleotides, prostanoides, dicarboxylates, and anionic drugs including beta-lactams, non-steroidal antiinflammatory drugs, diuretics and antiviral drugs. p-Aminohippuric Acid 91-107 solute carrier family 22 member 6 Rattus norvegicus 0-4 11504818-5 2001 The affinity of PAH, a common substrate for the OAT family, for rOat2 is low (K(i) > 1 mM) compared with the other members of the OAT family (rOat1 and rOat3). p-Aminohippuric Acid 16-19 solute carrier family 22 member 6 Rattus norvegicus 145-150 10991988-8 2000 [(14)C]PAH efflux was significantly enhanced when the rOAT1-expressing oocytes were incubated in the presence of unlabeled PAH, alpha-ketoglutarate, acetazolamide, chlorothiazide, or hydrochlorothiazide. p-Aminohippuric Acid 7-10 solute carrier family 22 member 6 Rattus norvegicus 54-59 10991988-4 2000 p-[(14)C]Aminohippurate (PAH) uptake by rOAT1-expressing oocytes was inhibited in the presence of a thiazide (chlorothiazide, cyclothiazide, hydrochlorothiazide), a loop diuretic (bumetanide, ethacrynic acid, furosemide), or a carbonic anhydrase inhibitor (acetazolamide, ethoxzolamide, methazolamide). p-Aminohippuric Acid 25-28 solute carrier family 22 member 6 Rattus norvegicus 40-45 10991988-8 2000 [(14)C]PAH efflux was significantly enhanced when the rOAT1-expressing oocytes were incubated in the presence of unlabeled PAH, alpha-ketoglutarate, acetazolamide, chlorothiazide, or hydrochlorothiazide. p-Aminohippuric Acid 123-126 solute carrier family 22 member 6 Rattus norvegicus 54-59 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 189-205 solute carrier family 22 member 6 Rattus norvegicus 76-81 10411577-2 1999 [(14)C]p-Aminohippurate (PAH) uptake via OAT1 expressed in Xenopus laevis oocytes was inhibited by all of the penicillins and cephalosporins tested. p-Aminohippuric Acid 7-23 solute carrier family 22 member 6 Rattus norvegicus 41-45 10411577-2 1999 [(14)C]p-Aminohippurate (PAH) uptake via OAT1 expressed in Xenopus laevis oocytes was inhibited by all of the penicillins and cephalosporins tested. p-Aminohippuric Acid 25-28 solute carrier family 22 member 6 Rattus norvegicus 41-45 10411577-3 1999 Penicillin G, carbenicillin, cephaloridine, cephalothin, cefazolin, and cephalexin inhibited [(14)C]PAH uptake via OAT1 in a competitive manner (K(i) = 0.29-2.33 mM). p-Aminohippuric Acid 100-103 solute carrier family 22 member 6 Rattus norvegicus 115-119 10411577-4 1999 Cinoxacin, a quinolone gyrase inhibitor, also inhibited PAH uptake via OAT1. p-Aminohippuric Acid 56-59 solute carrier family 22 member 6 Rattus norvegicus 71-75 10854830-2 2000 Uptake of p-aminohippurate via rOAT1 was markedly inhibited by glibenclamide and nateglinide, and moderately by chlorpropamide and tolbutamide. p-Aminohippuric Acid 10-26 solute carrier family 22 member 6 Rattus norvegicus 31-36 10049739-1 1999 The cloned organic anion transporters from rat, mouse, and winter flounder (rOAT1, mOAT1, fROAT) mediate the coupled exchange of alpha-ketoglutarate with multiple organic anions, including p-aminohippurate (PAH). p-Aminohippuric Acid 207-210 solute carrier family 22 member 6 Rattus norvegicus 76-81 31125610-10 2019 All of which deteriorated para-aminohippurate transport by down-regulating Oat1 during sudden ischaemia. p-Aminohippuric Acid 26-45 solute carrier family 22 member 6 Rattus norvegicus 75-79 9827570-2 1998 Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, alpha-ketoglutarate and probenecid, moderately inhibited by folate and methotrexate, but not inhibited by taurocholate or tetraethylammonium. p-Aminohippuric Acid 10-26 solute carrier family 22 member 6 Rattus norvegicus 59-63 9827570-2 1998 Uptake of p-aminohippurate (PAH) by the oocytes expressing OAT1 was markedly inhibited by glutarate, alpha-ketoglutarate and probenecid, moderately inhibited by folate and methotrexate, but not inhibited by taurocholate or tetraethylammonium. p-Aminohippuric Acid 28-31 solute carrier family 22 member 6 Rattus norvegicus 59-63 9827570-5 1998 OAT1-mediated PAH uptake was markedly inhibited by phorbol 12-myristate 13-acetate (PMA), phorbol 12,13-dibutyrate and mezerein, but not by 4alpha-phorbol 12,13-didecanoate. p-Aminohippuric Acid 14-17 solute carrier family 22 member 6 Rattus norvegicus 0-4 9374486-5 1997 ROAT1-mediated transport of 50 mu M [3H]PAH was independent of imposed changes in membrane potential. p-Aminohippuric Acid 40-43 solute carrier family 22 member 6 Rattus norvegicus 0-5 9374486-9 1997 Finally, ROAT1-mediated PAH transport was saturable, with an estimated Km of 70 mu M. Each of these properties is identical to those previously described for the basolateral alpha-ketoglutarate/PAH exchanger in isolated membrane vesicles or intact renal tubules. p-Aminohippuric Acid 24-27 solute carrier family 22 member 6 Rattus norvegicus 9-14 9374486-9 1997 Finally, ROAT1-mediated PAH transport was saturable, with an estimated Km of 70 mu M. Each of these properties is identical to those previously described for the basolateral alpha-ketoglutarate/PAH exchanger in isolated membrane vesicles or intact renal tubules. p-Aminohippuric Acid 194-197 solute carrier family 22 member 6 Rattus norvegicus 9-14 9228014-5 1997 The uptake rate of PAH was increased by the outwardly directed dicarboxylate gradient, consisting with the idea that OAT1 is an organic anion/dicarboxylate exchanger. p-Aminohippuric Acid 19-22 solute carrier family 22 member 6 Rattus norvegicus 117-121 29436232-10 2018 PAH uptake was completely blocked by 3 mM cephalothin (inhibits both oat1 and oat3), while 17% of PAH uptake was inhibited by 0.2 mM cephalothin (selectively inhibits oat3). p-Aminohippuric Acid 0-3 solute carrier family 22 member 6 Rattus norvegicus 69-73