PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23184075-10 2012 Protein expressions of PDGF-A, PDGF-C and PDGFRalpha were significantly higher in the DOCA and DOCA+IMA groups than those in the CON group, but the p-PDGFRalpha protein expression in the DOCA+IMA group was lower than that in the DOCA group. Desoxycorticosterone Acetate 86-90 platelet derived growth factor receptor alpha Rattus norvegicus 42-52 24427322-6 2014 2) At days 14, the mRNA expressions of PDGFRalpha and PDGFRbeta in DOCA group were significantly higher than CON and DOCA+IMA group. Desoxycorticosterone Acetate 67-71 platelet derived growth factor receptor alpha Rattus norvegicus 39-49 24427322-6 2014 2) At days 14, the mRNA expressions of PDGFRalpha and PDGFRbeta in DOCA group were significantly higher than CON and DOCA+IMA group. Desoxycorticosterone Acetate 117-121 platelet derived growth factor receptor alpha Rattus norvegicus 39-49 24427322-10 2014 3) At 14 days, the protein expressions of PDGFRalpha and PDGFRbeta in DOCA group were significantly higher than those in CON group. Desoxycorticosterone Acetate 70-74 platelet derived growth factor receptor alpha Rattus norvegicus 42-52 24427322-11 2014 The PDGFRalpha protein expression in DOCA+IMA group was markedly lower than that in DOCA group. Desoxycorticosterone Acetate 37-41 platelet derived growth factor receptor alpha Rattus norvegicus 4-14 24427322-11 2014 The PDGFRalpha protein expression in DOCA+IMA group was markedly lower than that in DOCA group. Desoxycorticosterone Acetate 84-88 platelet derived growth factor receptor alpha Rattus norvegicus 4-14 24427322-12 2014 At days 28, the protein expressions of PDGFRalpha and PDGFRbeta in DOCA group were significantly increased when compared with CON group. Desoxycorticosterone Acetate 67-71 platelet derived growth factor receptor alpha Rattus norvegicus 39-49 24427322-13 2014 The protein expressions of PDGFRalpha and PDGFRbeta in DOCA+IMA group were significantly lower than those in DOCA group. Desoxycorticosterone Acetate 55-59 platelet derived growth factor receptor alpha Rattus norvegicus 27-37 24427322-13 2014 The protein expressions of PDGFRalpha and PDGFRbeta in DOCA+IMA group were significantly lower than those in DOCA group. Desoxycorticosterone Acetate 109-113 platelet derived growth factor receptor alpha Rattus norvegicus 27-37 24427322-18 2014 Thus, During myocardial fibrosis of DOCA induced salt-sensitive hypertensive rats, PDGFRalpha acts at early stage, but PDGFRbeta functions in the whole process. Desoxycorticosterone Acetate 36-40 platelet derived growth factor receptor alpha Rattus norvegicus 83-93 24228109-6 2013 At 14 days, in DOCA group, the myocardial inflammation was obvious, ED-1 expression increased markedly, the mRNA expressions of PDGF-A, PDGF-B, PDGF-C, PDGFRalpha and PDGFRbeta increased to different extents, protein expressions of PDGFRalpha and PDGFRbeta also elevated markedly (P<0.01), but the PDGF-D mRNA expression remained unchanged, when compared with CON group. Desoxycorticosterone Acetate 15-19 platelet derived growth factor receptor alpha Rattus norvegicus 152-162 24228109-6 2013 At 14 days, in DOCA group, the myocardial inflammation was obvious, ED-1 expression increased markedly, the mRNA expressions of PDGF-A, PDGF-B, PDGF-C, PDGFRalpha and PDGFRbeta increased to different extents, protein expressions of PDGFRalpha and PDGFRbeta also elevated markedly (P<0.01), but the PDGF-D mRNA expression remained unchanged, when compared with CON group. Desoxycorticosterone Acetate 15-19 platelet derived growth factor receptor alpha Rattus norvegicus 232-242 24228109-8 2013 CONCLUSION: In DOCA/salt induced hypertensive rats with MF, excessive activation of PDGF/PDGFR signaling pathway is involved in myocardial inflammation. Desoxycorticosterone Acetate 15-19 platelet derived growth factor receptor alpha Rattus norvegicus 89-94 23184075-10 2012 Protein expressions of PDGF-A, PDGF-C and PDGFRalpha were significantly higher in the DOCA and DOCA+IMA groups than those in the CON group, but the p-PDGFRalpha protein expression in the DOCA+IMA group was lower than that in the DOCA group. Desoxycorticosterone Acetate 95-99 platelet derived growth factor receptor alpha Rattus norvegicus 42-52 23184075-10 2012 Protein expressions of PDGF-A, PDGF-C and PDGFRalpha were significantly higher in the DOCA and DOCA+IMA groups than those in the CON group, but the p-PDGFRalpha protein expression in the DOCA+IMA group was lower than that in the DOCA group. Desoxycorticosterone Acetate 95-99 platelet derived growth factor receptor alpha Rattus norvegicus 42-52 23184075-10 2012 Protein expressions of PDGF-A, PDGF-C and PDGFRalpha were significantly higher in the DOCA and DOCA+IMA groups than those in the CON group, but the p-PDGFRalpha protein expression in the DOCA+IMA group was lower than that in the DOCA group. Desoxycorticosterone Acetate 95-99 platelet derived growth factor receptor alpha Rattus norvegicus 42-52 23184075-11 2012 CONCLUSION: Imatinib can exert inhibitory effects on myocardial fibrosis in DOCA/salt induced hypertensive rats, which may be attributed to the inhibition of PDGFR-alpha activity. Desoxycorticosterone Acetate 76-80 platelet derived growth factor receptor alpha Rattus norvegicus 158-169