PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7579732-3 1995 Antifolates for which KB-derived mFBP has high affinity (5, 10-dideazatetrahydrofolic acid [DDATHF] and homo-DDATHF [0.24 and 0.78 respectively relative to folic acid]) and low affinity (methotrexate [0.002]) were chosen for this study. Folic Acid 80-90 far upstream element (FUSE) binding protein 1 Mus musculus 33-37 7641196-1 1995 The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells. Folic Acid 34-40 far upstream element (FUSE) binding protein 1 Mus musculus 58-62 7641196-1 1995 The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells. Folic Acid 80-86 far upstream element (FUSE) binding protein 1 Mus musculus 58-62 7641196-1 1995 The role of a membrane-associated folate binding protein (mFBP) in transport of folate analogues was investigated in three epithelial cell lines that were grown in high folate medium and folate-conditioned medium and express different levels of mFBP: human nasopharyngeal KB cells, monkey kidney MA104 cells, and IGROV-I ovarian carcinoma cells. Folic Acid 80-86 far upstream element (FUSE) binding protein 1 Mus musculus 58-62 1655252-1 1991 L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). Folic Acid 135-141 far upstream element (FUSE) binding protein 1 Mus musculus 159-163 1655252-1 1991 L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). Folic Acid 96-103 far upstream element (FUSE) binding protein 1 Mus musculus 159-163 1655252-1 1991 L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). Folic Acid 96-102 far upstream element (FUSE) binding protein 1 Mus musculus 159-163 8242637-7 1993 The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells. Folic Acid 40-50 far upstream element (FUSE) binding protein 1 Mus musculus 4-7 8242637-7 1993 The FBP-transfected NIH/3T3 cells bound folic acid and internalized about 30-fold more folic acid than mock-transfected cells. Folic Acid 87-97 far upstream element (FUSE) binding protein 1 Mus musculus 4-7 8242637-8 1993 Growth analysis revealed that FBP-transfected NIH/3T3 cells like IGROV1 maintained their growth rate after 10 days of culture in medium containing physiological or low folate concentration, and tumors arising after transplanting FBP-tNIH/3T3 cells in nude mice were 3-fold heavier than those arising after transplantation of non-FBP-expressing NIH/3T3 cells. Folic Acid 168-174 far upstream element (FUSE) binding protein 1 Mus musculus 30-33 1533575-4 1992 The increase of the mFBP expression, besides ensuring the growth of resistant cells by its contribution to the reduced folate intake, also participates in the methotrexate resistance by the internalization of folate cofactor which would compete with methotrexate hindering the effective inhibition of dihydrofolate reductase by the antifolate. Folic Acid 119-125 far upstream element (FUSE) binding protein 1 Mus musculus 20-24 1655252-1 1991 L1210-B73 cells, variants of L1210 cells grown in medium containing nanomolar concentrations of folates, express a membrane associated folate binding protein (mFBP) in addition to the classical reduced folate/methotrexate carrier (RF/MTX-carrier) present in L1210 cells grown in standard high folate medium (G. Jansen et al., Cancer Res., 49: 1959-1963, 1989). Folic Acid 135-141 far upstream element (FUSE) binding protein 1 Mus musculus 159-163 1655252-2 1991 In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds. Folic Acid 139-145 far upstream element (FUSE) binding protein 1 Mus musculus 118-122 1655252-2 1991 In this study we used L1210-B73 and L1210 cells as a model system to study the affinity of the RF/MTX-carrier and the mFBP for the natural folate compounds folic acid and 5-formyltetrahydrofolate (5-CHO-THF), as well as a number of antifolate compounds. Folic Acid 156-166 far upstream element (FUSE) binding protein 1 Mus musculus 118-122 1655252-7 1991 Binding affinities of the mFBP decreased in the order CB3717 greater than or equal to folic acid = ICI-198,583 greater than or equal to 5-CHO-THF much greater than MTX = 10-EdAM. Folic Acid 86-96 far upstream element (FUSE) binding protein 1 Mus musculus 26-30 1655252-8 1991 Over 24 h, at 25 nM, [3H]folic acid uptake in L1210-B73 cells was found to proceed for more than 98% via the mFBP. Folic Acid 25-35 far upstream element (FUSE) binding protein 1 Mus musculus 109-113 2060081-3 1991 These routes include the classic reduced folate carrier and a membrane-associated folate-binding protein (mFBP). Folic Acid 41-47 far upstream element (FUSE) binding protein 1 Mus musculus 106-110 1894617-2 1991 L1210 murine leukemic cells grown under conditions of continuous low folate concentrations acquire increased levels of a high affinity/low capacity folate-binding protein (FBP). Folic Acid 69-75 far upstream element (FUSE) binding protein 1 Mus musculus 148-170 1894617-2 1991 L1210 murine leukemic cells grown under conditions of continuous low folate concentrations acquire increased levels of a high affinity/low capacity folate-binding protein (FBP). Folic Acid 69-75 far upstream element (FUSE) binding protein 1 Mus musculus 172-175 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 325-335 far upstream element (FUSE) binding protein 1 Mus musculus 15-19 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 325-335 far upstream element (FUSE) binding protein 1 Mus musculus 89-93 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 325-335 far upstream element (FUSE) binding protein 1 Mus musculus 89-93 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 356-362 far upstream element (FUSE) binding protein 1 Mus musculus 15-19 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 356-362 far upstream element (FUSE) binding protein 1 Mus musculus 89-93 2060081-4 1991 The role of an mFBP in the uptake of DDATHF was suggested from observations that (a) the mFBP showed a very high binding affinity for DDATHF, (b) murine and human leukemia cells expressing an mFBP were highly sensitive to growth inhibition by DDATHF, and (c) protection against this growth inhibition could be achieved using folic acid rather than reduced folate compounds. Folic Acid 356-362 far upstream element (FUSE) binding protein 1 Mus musculus 89-93